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Chinese medicinal composition treating bile reflux gastritis and its preparation method

The technology of bile reflux and composition, which is applied in the field of traditional Chinese medicine treatment of bile reflux gastritis, can solve the problems of slow effect and insufficient curative effect, and achieves the effects of definite curative effect, quick curative effect and good safety.

Inactive Publication Date: 2012-06-13
黄文珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the existing Chinese patent medicines for the treatment of bile reflux gastritis have defects such as slow effect and insufficient curative effect, which need to be improved

Method used

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  • Chinese medicinal composition treating bile reflux gastritis and its preparation method
  • Chinese medicinal composition treating bile reflux gastritis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 capsule

[0049] (1) Weigh the pure medicinal materials (unit: g): Radix Paeoniae Alba 25, Toosendan 25, Inula 20, Nutmeg 25, Piperumba 20, Sandalwood 15, Agarwood 15, Bupleurum 8, Bergamot 8, Evodia 8, ochre 2, licorice 4.

[0050] (2) Preparation of dry extract

[0051] Mix the above raw materials together and decoct twice with water, add 10 times the weight of water for 2.5 hours for the first time, add 8 times the weight of water for 1.5 hours for the second time, filter the decoction, and combine Filtrate, the filtrate is concentrated to a thick paste with a relative density of 1.06-1.10 (55°C), spray-dried to obtain a dry extract, and set aside;

[0052] (3) Preparation of capsules

[0053] Take medicinal material fine powder and dry extract, add appropriate amount of lactose, mix evenly, dry press into granules, put into capsules, and get ready; each capsule contains 1.33g of effective crude drug.

Embodiment 2

[0054] The preparation of embodiment 2 capsules

[0055] (1) Weigh the pure medicinal materials (unit: g): 15 raw white peony root, 15 toosendan, 12 inula inulae, 15 nutmeg, 10 Piperumba 10, 10 sandalwood, 10 agarwood, 5 bupleurum, 5 bergamot, Evodia 5, ochre 1, licorice 2.

[0056] (2) Preparation of dry extract

[0057] Mix the above raw materials together and decoct twice with water, add 10 times the weight of water for 2.5 hours for the first time, add 8 times the weight of water for 1.5 hours for the second time, filter the decoction, and combine Filtrate, the filtrate is concentrated to a thick paste with a relative density of 1.06-1.10 (55°C), spray-dried to obtain a dry extract, and set aside;

[0058] (3) Preparation of capsules

[0059] Take medicinal material fine powder and dry extract, add appropriate amount of lactose, mix evenly, dry press into granules, put into capsules, and get ready; each capsule contains 1.33g of effective crude drug.

Embodiment 3

[0060] The preparation of embodiment 3 capsules

[0061] (1) Weigh the pure medicinal materials (unit: g): 30 raw white peony root, 30 toosendan, 25 inflorescence, 30 nutmeg, 25 Piperia chinensis, 20 sandalwood, 20 agarwood, 12 bupleurum, 12 bergamot, Evodia 12, ochre 5, licorice 8;

[0062] (2) Preparation of dry extract

[0063] Mix the above raw materials together and decoct twice with water, add 10 times the weight of water for 2.5 hours for the first time, add 8 times the weight of water for 1.5 hours for the second time, filter the decoction, and combine Filtrate, the filtrate is concentrated to a thick paste with a relative density of 1.06-1.10 (55°C), spray-dried to obtain a dry extract, and set aside;

[0064] (3) Preparation of capsules

[0065] Take medicinal material fine powder and dry extract, add appropriate amount of lactose, mix evenly, dry press into granules, put into capsules, and get ready; each capsule contains 1.33g of effective crude drug.

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Abstract

The invention discloses a Chinese medicinal composition treating bile reflux gastritis and its preparation method. The composition is prepared by the following bulk drugs by weight: 15-30 parts of crude white peony roots, 15-30 pats of Fructus Toosendan, 12-25 parts of Flos Inulae, 15-30 parts of netmeg, 10-25 parts of long pepper, 10-20 parts of sandalwood,10-20 parts of agilawood, 5-12 parts of radix bupleuri, 5-12 parts of finger citron, 5-12 parts of Evodia rutaecarpa, 1-5 parts of ruddle and 2-8 parts of licorice. According to conventional Chinese traditional medicine preparation methods, the Chinese medicinal composition of the invention can be prepared into any of clinically acceptable oral medicinal preparations. Clinical observation results show that, the Chinese medicinal composition of the invention has obvious curative effects on bile reflux gastritis; while safety observation finds that, no clinical adverse reaction is observed. Thus, the Chinese medicinal composition of the invention is characterized by safe clinical application, and no toxic or side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating bile reflux gastritis and a preparation method thereof, belonging to the field of traditional Chinese medicine treatment of bile reflux gastritis. Background technique [0002] Bile reflux gastritis refers to a syndrome of epigastric pain, bile vomiting, abdominal distension, and weight loss caused by bile reflux into the stomach. Direct contact of bile with gastric mucosa generally does not cause damage, but it can stimulate gastric acid secretion. The combination of bile salt and gastric acid can enhance the activity of acid hydrolytic enzymes, destroy lysosomes, dissolve lipoproteins in the membrane, and destroy the barrier function of gastric mucosa. H + Increased reverse diffusion into the mucosa and submucosa can stimulate mast cells to release histamine, which in turn stimulates the secretion of gastric ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/835A61K36/8968A61K36/8998A61K36/9068A61P1/04A61K33/26A61K35/37A61K35/57
Inventor 黄文珍
Owner 黄文珍
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