Traditional Chinese medicine compound preparation for treating multiple myeloma and preparation method

Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating multiple myeloma and a preparation method, and particularly relates to the technical field of traditional Chinese medicines. The preparation comprises astragalus membranaceus, cistanche deserticola, semen cuscutae, salted fructus psoraleae, oldenlandia diffusa, semen plantaginis, angelica sinensis, caulis spatholobi, cortex moutan, lumbricus, centipede, bighead atractylodes rhizome, curcuma zedoary, salvia miltiorrhiza, pseudobulbus cremastrae seu pleiones and liquorice. The traditional Chinese medicine compound preparation for treating multiple myeloma is a pure traditional Chinese medicine preparation, stimulation to the stomach of a patient and toxic and side effects to the liver are avoided, a large number of people practices prove that the traditional Chinese medicine compound preparation is safe, reliable and free of obvious adverse reactions, the preparation method is simple, no pollution is caused to the environment, and the traditional Chinese medicine compound preparation has great application and popularization value.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine compound preparation for treating multiple myeloma and a preparation method thereof. Background Art

[0002] Multiple myeloma (MM) is a malignant plasma cell disease that occurs in B lymphocytes. It is common in middle-aged and elderly people, but the incidence has increased and the age of onset has tended to be earlier in recent years. The cause of multiple myeloma has not yet been clearly determined. Clinical observations, epidemiological surveys, and animal experiments suggest that ionizing radiation, chronic antigen stimulation, genetic factors, and viral infections may be related to the onset of MM.

[0003] Myelodysplastic syndrome is a malignant clonal disease of hematopoietic stem cells. Its main characteristics are ineffective erythropoiesis accompanied by varying degrees of normal or excessive granulocyte and megakaryocyte maturation disorders; the appearance of morphologically abnormal promyelocytic leukemia-like primitive cells (≥20%) and (or) immature neutrophils of various stages (≥20%) in peripheral blood; splenomegaly with extramedullary hematopoiesis, etc. This disease can occur in any age group, but most cases occur in the elderly. In recent years, with the increasing trend of population aging and the advancement and development of medical technology, the incidence of MDS has increased significantly. It is currently believed that MDS is a hematopoietic stem cell disease with a certain degree of heterogeneity. The occurrence and development of the disease are related to genetic factors and environmental factors, but the specific mechanism is still unclear. Multiple myeloma is a painless and itchy blood system malignancy originating from plasma cells. It is characterized by excessive proliferation of monoclonal plasma cells and the production of monoclonal immunoglobulins, and the proliferation of monoclonal plasma cells in the bone marrow and invasion of various components of bonemarrow and other organs. Clinically, there are anemia, bone destruction, renal insufficiency, immune damage, hypercalcemia, amyloidosis and other related problems. Traditional Chinese medicine has a unique effect in the treatment of multiple myeloma, but how to make the effect better is one of the problems that urgently need to be solved.

[0004] According to TCM theory, multiple myeloma belongs to the category of "bone arthritis, bone erosion, asthenia, and blood syndrome". This disease is mostly caused by congenital deficiency or acquired malnutrition, kidney deficiency, exogenous evil taking advantage of the weakness to invade the body, poor circulation of qi and blood, and accumulation of toxic blood; arthritis blocks the meridians, and the joints and meridians are not nourished, resulting in this disease. Over time, the accumulation of toxic blood often easily turns into heat, as recorded in "Lingshu·Acupuncture of the True Evil": "When the virtual evil enters the body deeply, the cold and heat fight each other, and stay for a long time and stick inside... Internal injury to the bone, internal injury to the bone is bone erosion.", "When the virtual evil invades the body... It enters deeply and fights the bone internally, it is bone arthritis." Therefore, the treatment should abide by the principle of "taking both the symptoms and the root cause into account". This prescription uses the method of invigorating qi, tonifying the kidney and nourishing yin, promoting blood circulation and removing blood stasis, and detoxifying to differentiate and treat, taking both the symptoms and the root cause into account, and improving the body's immunity.

[0005] Since the pathogenesis of myeloma has not been fully elucidated, there is currently no cure. Radiotherapy and chemotherapy are the main means of treating myeloma, but their efficacy is limited and their side effects are large, which patients often find difficult to tolerate. As an important part of traditional Chinese medicine, traditional Chinese medicine has unique advantages in treating myeloma.

[0006] Chinese herbal compound preparations can effectively alleviate the clinical symptoms of myeloma patients. The combination of Chinese and Western medicine can enhance the efficacy and reduce the side effects of myeloma after radiotherapy and chemotherapy. Summary of the invention

[0007] To this end, the present invention provides a Chinese medicinal compound preparation for treating multiple myeloma and a preparation method thereof to solve the above-mentioned problems.

[0008] In order to achieve the above object, the present invention provides the following technical solutions:

[0009] According to the first aspect of the present invention, a traditional Chinese medicine composition for treating multiple myeloma is provided, which comprises astragalus, cistanche, dodder seed, psoralea corylifolia, oldenlandia diffusa, plantain seed, angelica, millettia reticulata, moutan bark, earthworm, centipede, atractylodes, curcuma, salvia miltiorrhiza, trifoliate orange, and licorice.

[0010] Further, the preparation includes 20-40 parts of astragalus, 10-30 parts of Cistanche, 10-30 parts of Cuscuta, 10-30 parts of Psoralea corylifolia, 20-40 parts of Hedyotis diffusa, 5-15 parts of Plantago, 5-15 parts of Angelica sinensis, 20-40 parts of Millettia spatholobi, 5-15 parts of Moutan bark, 20-40 parts of Pheretima, 1-5 parts of Scolopendra, 20-40 parts of Atractylodes macrocephala, 20-40 parts of Curcuma, 20-40 parts of Salvia miltiorrhiza, 5-15 parts of Trillium, and 5-15 parts of Licorice.

[0011] Further, the preparation includes 30 parts of Astragalus, 20 parts of Cistanche, 20 parts of Cuscuta, 20 parts of Psoralea corylifolia, 30 parts of Hedyotis diffusa, 10 parts of Plantago, 6 parts of Angelica sinensis, 15 parts of Millettia reticulata, 9 parts of Moutan, 15 parts of Pheretima, 2 parts of Scolopendra, 15 parts of Atractylodes macrocephala, 15 parts of Curcuma, 30 parts of Salvia miltiorrhiza, 10 parts of Trillium, and 6 parts of Licorice.

[0012] Further, the preparation includes 20 parts of Astragalus, 10 parts of Cistanche, 10 parts of Cuscuta, 10 parts of Psoralea corylifolia, 20 parts of Hedyotis diffusa, 5 parts of Plantago, 5 parts of Angelica sinensis, 20 parts of Millettia reticulata, 5 parts of Moutan bark, 20 parts of Pheretima, 1 part of Scolopendra, 20 parts of Atractylodes macrocephala, 20 parts of Curcuma, 20 parts of Salvia miltiorrhiza, 5 parts of Trillium, and 5 parts of Licorice.

[0013] Further, the preparation includes 40 parts of Astragalus, 30 parts of Cistanche, 30 parts of Cuscuta, 30 parts of Psoralea corylifolia, 40 parts of Hedyotis diffusa, 15 parts of Plantago, 15 parts of Angelica sinensis, 40 parts of Millettia reticulata, 15 parts of Moutan bark, 40 parts of Pheretima, 5 parts of Scolopendra, 40 parts of Atractylodes macrocephala, 40 parts of Curcuma, 40 parts of Salvia miltiorrhiza, 15 parts of Trillium, and 15 parts of Licorice.

[0014] According to a second aspect of the present invention, a Chinese medicine compound preparation for treating multiple myeloma is provided, the preparation comprising the Chinese medicine composition as described above and a pharmaceutically acceptable carrier or diluent.

[0015] Furthermore, the Chinese medicine compound preparation is in the form of granules, tablets, capsules, pills, decoctions, or syrups.

[0016] Furthermore, the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of a filler, a binder, a disintegrant, a lubricant, a surfactant or a flavoring agent.

[0017] Furthermore, the filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose.

[0018] Furthermore, the adhesive is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone.

[0019] "Ben Cao Feng Yuan" records that "Huangqi can replenish the five internal organs and all deficiencies", and replenish qi and generate blood. The effective ingredients such as saponins and polysaccharides contained in Huangqi have pharmacological activities such as regulating immunity, anti-tumor, and protecting the liver. Angelica can both replenish blood and activate blood circulation. It can also activate collaterals while dredging menstruation. The polysaccharide chemical components contained in angelica can play the role of hematopoietic function to promote the differentiation and proliferation of hematopoietic cells, stimulate the hematopoietic microenvironment to promote the release of hematopoietic growth factors, and finally promote the formation of hematopoietic cells; at the same time, angelica also has anti-thrombotic activity, which may be related to its reduction of plasma fibrinogen concentration. In combination with Millettia reticulata to increase the nature of activating blood circulation, Millettia reticulata can also dredge meridians and activate collaterals, straighten meridians, and dredge local qi and blood. Earthworms have a mild nature and can clear away heat and wind, promote diuresis, and master of traditional Chinese medicine Mr. Li Shimao believes that earthworms are good at clearing large veins and can break dead blood. The nature of earthworms can be used to treat the symptoms of blood stasis and water stasis. Centipedes can enter the meridians to search for evil, detoxify and fight cancer, and break blood stasis and relieve pain. The polysaccharides, volatile oils and other active substances isolated from Atractylodes macrocephala have anti-tumor effects. Scholars extracted the polysaccharide component PEHD from Hedyotis diffusa for research and found that Hedyotis diffusa can resist the growth of myeloma cell lines and inhibit the proliferation of myeloma cells, and promote their apoptosis and necrosis. The isoflavones contained in licorice have a positive effect on anti-tumor invasion and promoting the increase of bone marrow cell numbers. Cuscuta has the effect of tonifying the kidney and replenishing essence, and Psoralea corylifolia has the effect of tonifying the kidney and strengthening yang. The combination of the two can enhance the effect of tonifying the kidney and replenishing qi. Plantago seed can clear away heat and detoxify, and is a commonly used medicine for detoxifying "heat and poison". It is combined with the heat-clearing, cooling, and blood-activating and blood-stasis-removing effects of Cortex Moutan to increase the effect of clearing heat and detoxifying, and can also clear away fever caused by multiple myeloma. Curcuma is an important medicine for promoting qi and relieving depression, breaking blood and promoting qi. In addition, modern research on Curcuma has a clear anti-tumor effect. Tripterygium wilfordii is sweet, slightly spicy, and cool in nature. It has the effects of clearing heat and detoxifying, eliminating carbuncle and dispersing knots, and is a commonly used anti-tumor medicine. "New Compendium of Materia Medica": Tripterygium wilfordii is the king of Yushu Dan, and can cure strange diseases. Most strange diseases are caused by phlegm, and Tripterygium wilfordii is a phlegm-removing medicine. Treating phlegm will eliminate strange diseases. Some people suspect that Tripterygium wilfordii is not a phlegm-removing medicine, but a poison-dispersing medicine. It is not known that the unformed poison is phlegm, and the condensed phlegm is poison. Phlegm and poison are not two different things. All these medicines work together to nourish the kidney, promote blood circulation and qi, promote blood circulation, remove blood stasis and fight cancer.

[0020] The present invention has the following advantages:

[0021] The Chinese medicinal composition for treating multiple myeloma is prepared by mixing 16 kinds of Chinese medicinal herbs, including astragalus, cistanche, dodder seed, psoralea corylifolia, oldenlandia diffusa, plantain seed, angelica, millettia reticulata, moutan bark, earthworm, centipede, atractylodes, curcuma, salvia miltiorrhiza, trifoliate bulb and liquorice. The Chinese medicinal composition has a good therapeutic effect on multiple myeloma through the synergistic effect between the 16 Chinese medicinal herbs. A large number of clinical trials show that the Chinese medicinal composition has a definite therapeutic effect.

[0022] The Chinese medicinal compound preparation for treating multiple myeloma of the present invention uses pure Chinese medicinal preparations, thus avoiding irritation to the patient's stomach and toxic side effects on the liver. It has been verified by practice of a large number of people that the preparation is safe and reliable, has no obvious adverse reactions, and has a simple preparation method and is pollution-free to the environment, thus having great value for promotion and application. DETAILED DESCRIPTION

[0023] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] Example 1

[0025] This embodiment provides a Chinese medicine composition for multiple myeloma:

[0026] The preparation comprises 30 parts of astragalus, 20 parts of cistanche, 20 parts of dodder seeds, 20 parts of salt psoralea, 30 parts of oldenlandia diffusa, 10 parts of plantain seeds, 6 parts of angelica, 15 parts of millettia reticulata, 9 parts of moutan bark, 15 parts of earthworm, 2 parts of centipede, 15 parts of atractylodes, 15 parts of curcuma, 30 parts of salvia miltiorrhiza, 10 parts of trifoliate ash and 6 parts of liquorice.

[0027] Example 2

[0028] This embodiment provides a Chinese medicine composition for multiple myeloma:

[0029] The preparation comprises 20 parts of astragalus, 10 parts of cistanche, 10 parts of dodder seeds, 10 parts of salt psoralea, 20 parts of oldenlandia diffusa, 5 parts of plantain seeds, 5 parts of angelica, 20 parts of millettia reticulata, 5 parts of moutan bark, 20 parts of earthworm, 1 part of centipede, 20 parts of atractylodes, 20 parts of curcuma, 20 parts of salvia miltiorrhiza, 5 parts of trifoliate ash and 5 parts of liquorice.

[0030] Example 3

[0031] This embodiment provides a Chinese medicine composition for multiple myeloma:

[0032] The preparation comprises 40 parts of astragalus, 30 parts of cistanche, 30 parts of cuscuta, 30 parts of salt psoralea, 40 parts of oldenlandia diffusa, 15 parts of plantain seeds, 15 parts of angelica, 40 parts of millettia reticulata, 15 parts of moutan bark, 40 parts of earthworm, 5 parts of centipede, 40 parts of atractylodes, 40 parts of curcuma, 40 parts of salvia miltiorrhiza, 15 parts of trifoliate ash, and 15 parts of liquorice.

[0033] Example 4

[0034] A traditional Chinese medicine preparation for treating multiple myeloma, wherein the traditional Chinese medicine preparation is prepared into a decoction by a conventional method from the traditional Chinese medicine composition described in Examples 1 to 3.

[0035] Specifically, step 1, mix the raw materials according to the above formula, add water to soak the medicine surface for 60 minutes;

[0036] Step 2: Continue to add water to the formula raw materials soaked in step 1 until the surface of the medicine is 3-4 cm above the medicine surface, boil over high heat until boiling, then continue to boil over low heat for 60 minutes until the remaining medicine liquid is concentrated to 100 mL, filter, and take the filtrate for later use;

[0037] Step 3: Continue to add water to the remaining medicine obtained in step 2 until it covers the medicine surface by 2-3 cm. Boil over high heat until boiling, then simmer over low heat for 60 minutes. Filter until the remaining medicine liquid is concentrated to 100 mL. Take the filtrate and mix it with the filtrate obtained in step 2.

[0038] Example 5

[0039] A Chinese medicine preparation for treating multiple myeloma, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0040] Take the Chinese medicine composition described in Examples 1 to 3, grind the above raw materials, add a pharmaceutically acceptable carrier or diluent, and granulate and dry according to conventional methods to prepare Chinese medicine granules.

[0041] Example 6

[0042] A Chinese medicine preparation for treating multiple myeloma, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0043] Take the Chinese medicine composition described in Examples 1 to 3, grind the above raw materials, add a pharmaceutically acceptable carrier or diluent, granulate according to conventional methods, fill capsules, and prepare Chinese medicine capsules.

[0044] Example 7

[0045] A Chinese medicine preparation for treating multiple myeloma, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0046] Take the Chinese medicine composition described in Examples 1 to 3, crush the above raw materials, add a pharmaceutically acceptable carrier or diluent, and prepare Chinese medicine pills according to conventional molding or panning methods.

[0047] Example 8

[0048] A Chinese medicine preparation for treating multiple myeloma, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of fillers, binders, disintegrants, lubricants, surfactants or flavoring agents. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone. The preparation method is as follows:

[0049] Take the Chinese medicine composition described in Examples 1 to 3, grind the above raw materials, add a pharmaceutically acceptable carrier or diluent, press into tablets according to conventional methods, and apply film coating to obtain Chinese medicine tablets.

[0050] Example 9

[0051] A Chinese medicine preparation for treating multiple myeloma, the Chinese medicine preparation is composed of the Chinese medicine composition described in Examples 1 to 3 and a pharmaceutically acceptable carrier or diluent; the pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of a filler, a binder, a disintegrant, a lubricant, a surfactant or a flavoring agent. The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose. The binder is selected from one or more of a cellulose derivative, alginate, gelatin or polyvinyl pyrrolidone.

[0052] The preparation method is as follows:

[0053] Take the Chinese medicine composition described in Examples 1 to 3, grind the above raw materials, add a pharmaceutically acceptable carrier or diluent such as sucrose, etc., and prepare a Chinese medicine syrup according to a conventional method.

[0054] Experimental example

[0055] In the research of the subject of the present invention, a total of 50 patients with multiple myeloma were collected and randomly divided into two groups. The control group was given bortezomib and dexamethasone, and the observation group was given the decoction of the Chinese medicine composition of Example 1 of the present invention on the basis of the control group. The results are shown in Table 1 below:

[0056] Table 1

[0057]

[0058] Note: Compared with before treatment, # P<0.05; compared with the control group, * P<0.05.

[0059] As shown in Table 1, in terms of VAS scores, the two groups of patients improved significantly after treatment compared with before treatment (p < 0.05), indicating that both treatments can effectively relieve bone pain, but after treatment, the VAS score of the observation group was more significantly relieved than that of the control group (p < 0.05). This shows that the observation group can better relieve the pain symptoms of patients. In terms of KPS scores, the observation group improved significantly after treatment compared with before treatment (p < 0.05), while the control group did not improve significantly before and after treatment (p > 0.05). And compared with the data of the two groups after treatment, the improvement of the observation group was more significant than that of the control group (p < 0.05), indicating that the observation group can better improve the quality of life of patients.

[0060] Clinical trials

[0061] Clinical experiments have confirmed that the Chinese medicine composition provided by the present invention is effective in treating multiple myeloma.

[0062] 1. General Information

[0063] Twenty patients with multiple myeloma were diagnosed in the hospital;

[0064] 2. Treatment methods

[0065] Treatment course: 12 weeks is one course of treatment.

[0066] Medication method: The Chinese medicine composition of Example 1 is made into a Chinese medicine decoction for oral administration, and the decoction is taken once in the morning and evening, warm, and taken half an hour before meals. During the medication period, avoid eating greasy, pork, mung beans and other cold foods.

[0067] 3. Diagnostic criteria

[0068] Supplementary diagnostic criteria:

[0069] The patient's diagnosis was in line with the "Guidelines for the Diagnosis and Treatment of Multiple Myeloma in China (Revised in 2020)", and was confirmed to have multiple myeloma through relevant pathological examinations.

[0070] 4. Efficacy evaluation criteria

[0071] Markedly effective: symptoms and signs are significantly improved, and the syndrome score is reduced by ≥70%;

[0072] Effective: symptoms and signs are improved, and the syndrome score is reduced by ≥30%;

[0073] Ineffective: There is no significant improvement in symptoms and signs, or they may even worsen, and the syndrome score decreases by less than 30%.

[0074] 5. Treatment results

[0075] Among the patients who received treatment, 16 cases were markedly effective, 2 cases were effective, and 2 cases were non-effective. From the treatment results, it can be seen that the Chinese medicine composition provided by the present invention has an effective rate of 90% for improving multiple myeloma, and has a definite therapeutic effect.

[0076] 6. Security

[0077] No aggravation of liver and kidney function was found in all observed patients, indicating the safety of the Chinese medicine composition.

[0078] Typical Cases

[0079] Case 1: Wang, male, 64 years old, from Hangzhou, Zhejiang; Time: June 2021, diagnosed with multiple myeloma due to low back pain and sternal pain, indicators: multiple bone destruction, obvious low back pain, pain score of 5 points, affecting sleep; after admission, he took the decoction preparation of Example 4 of the present invention, once in the morning and evening, warm, and after 9 weeks of intervention, the patient's pain improved and the score dropped to 1 point. It proves that the Chinese medicine preparation of the present invention is effective.

[0080] Case 2: Zhang, female, 68 years old, from Chuzhou, Anhui; Time: January 2022, diagnosed with multiple myeloma due to sternal pain and anemia, multiple bone destruction throughout the body, ribs prominent, pain score 6 points; after admission, began to take the granules of Example 5 of the present invention, 10g per bag, 1 bag each time, three times a day, taken with warm water, and the pain score dropped to 2 points after 10 weeks. It proves that the Chinese medicine preparation of the present invention is effective.

[0081] Case 3: Zhang, male, 72 years old, from Tonglu, Zhejiang; Time: July 2021, he was diagnosed with multiple myeloma due to fatigue and low back pain, with obvious lumbar bone destruction and a pain score of 4. After admission, he took the decoction preparation of Example 6 of the present invention, once in the morning and evening, warm. After 9 weeks of intervention, the patient's pain improved and the score dropped to 0. It is proved that the Chinese medicine preparation of the present invention is effective.

[0082] Case 4: Song, female, 59 years old, from Ganzhou, Jiangxi; Time: December 2021, she was diagnosed with multiple myeloma due to back pain and edema, with obvious multiple bone destruction throughout the body and a pain score of 5 points. After admission, she took the decoction preparation of Example 2 of the present invention, once in the morning and evening, warm. After 10 weeks of intervention, the patient's pain improved and the score dropped to 1 point. It proves that the Chinese medicine preparation of the present invention is effective.

[0083] Case 5: Zhang, male, 79 years old, from Hangzhou, Zhejiang; Time: June 2022, he was diagnosed with multiple myeloma due to fatigue and chest pain, with multiple bone destruction throughout the body, especially in the ribs. The pain score was 6 points. After admission, he took the decoction preparation of Example 1 of the present invention, once in the morning and once in the evening, warm. After 12 weeks of intervention, the patient's pain improved and the score dropped to 2 points. It proves that the Chinese medicine preparation of the present invention is effective.

[0084] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A Chinese medicine composition for treating multiple myeloma, characterized in that: The preparation comprises astragalus, cistanche, dodder seed, psoralea corylifolia, oldenlandia diffusa, plantain seed, angelica, millettia reticulata, moutan bark, earthworm, centipede, atractylodes, curcuma, salvia miltiorrhiza, trifoliate bulb, and liquorice.

2. A Chinese medicine composition for treating multiple myeloma according to claim 1, characterized in that: The preparation comprises 20-40 parts of astragalus, 10-30 parts of cistanche, 10-30 parts of dodder seeds, 10-30 parts of psoralea corylifolia, 20-40 parts of oldenlandia diffusa, 5-15 parts of plantain seeds, 5-15 parts of angelica, 20-40 parts of millettia spatholobi, 5-15 parts of moutan bark, 20-40 parts of earthworm, 1-5 parts of centipede, 20-40 parts of atractylodes, 20-40 parts of curcuma, 20-40 parts of salvia miltiorrhiza, 5-15 parts of trifoliate horn mushroom and 5-15 parts of liquorice.

3. A Chinese medicine composition for treating multiple myeloma according to claim 2, characterized in that: The preparation comprises 30 parts of astragalus, 20 parts of cistanche, 20 parts of dodder seeds, 20 parts of salt psoralea, 30 parts of oldenlandia diffusa, 10 parts of plantain seeds, 6 parts of angelica, 15 parts of millettia reticulata, 9 parts of moutan bark, 15 parts of earthworm, 2 parts of centipede, 15 parts of atractylodes, 15 parts of curcuma, 30 parts of salvia miltiorrhiza, 10 parts of trifoliate ash and 6 parts of liquorice.

4. A Chinese medicine composition for treating multiple myeloma according to claim 2, characterized in that: The preparation comprises 20 parts of astragalus, 10 parts of cistanche, 10 parts of dodder seeds, 10 parts of salt psoralea, 20 parts of oldenlandia diffusa, 5 parts of plantain seeds, 5 parts of angelica, 20 parts of millettia reticulata, 5 parts of moutan bark, 20 parts of earthworm, 1 part of centipede, 20 parts of atractylodes, 20 parts of curcuma, 20 parts of salvia miltiorrhiza, 5 parts of trifoliate ash and 5 parts of liquorice.

5. A Chinese medicine composition for treating multiple myeloma according to claim 2, characterized in that: The preparation comprises 40 parts of astragalus, 30 parts of cistanche, 30 parts of cuscuta, 30 parts of salt psoralea, 40 parts of oldenlandia diffusa, 15 parts of plantain seeds, 15 parts of angelica, 40 parts of millettia reticulata, 15 parts of moutan bark, 40 parts of earthworm, 5 parts of centipede, 40 parts of atractylodes, 40 parts of curcuma, 40 parts of salvia miltiorrhiza, 15 parts of trifoliate ash, and 15 parts of liquorice.

6. A Chinese medicinal compound preparation for treating multiple myeloma, characterized in that: The preparation comprises the traditional Chinese medicine composition as claimed in claim 1 and a pharmaceutically acceptable carrier or diluent.

7. A Chinese medicinal compound preparation for treating multiple myeloma according to claim 6, characterized in that: The Chinese medicine compound preparation is in the form of granules, tablets, capsules, pills, decoctions and syrups.

8. The Chinese medicinal compound preparation for treating multiple myeloma according to claim 6, characterized in that: The pharmaceutically acceptable carrier or diluent refers to a conventional drug carrier in the pharmaceutical field, selected from one or more of a filler, a binder, a disintegrant, a lubricant, a surfactant or a flavoring agent.

9. A Chinese medicinal compound preparation for treating multiple myeloma according to claim 8, characterized in that: The filler is selected from one or more of starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose or glucose.

10. A Chinese medicinal compound preparation for treating multiple myeloma according to claim 9, characterized in that: The adhesive is selected from one or more of cellulose derivatives, alginate, gelatin or polyvinyl pyrrolidone.

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