45results about How to "Ensure penetration" patented technology

Improved microneedle arrays are provided having a sufficiently large separation distance between each of the individual microneedles to ensure penetration of the skin while having a sufficiently small separation distance to provide high transdermal transport rates. A very useful range of separation distances between microneedles is in the range of 100-300 microns, and more preferably in the range of 100-200 microns. The outer diameter and microneedle length is also very important, and in combination with the separation distance will be crucial as to whether or not the microneedles will actually penetrate the stratum corneum of skin. For circular microneedles, a useful outer diameter range is from 20-100 microns, and more preferably in the range of 20-50 microns. For circular microneedles that do not have sharp edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 100-150 microns; for use with other biological fluids, a useful length is in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns. For circular microneedles having sharp side edges, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns. For solid microneedles having a star-shaped profile with sharp edges for its star-shaped blades, a useful length for use with interstitial fluids is in the range of 50-200 microns, and more preferably in the range of 80-150 microns; for use with other biological fluids, a useful length is again in the range of 200 microns—3 mm, and more preferably in the range of 200-400 microns, while the radius of each of its blades is in the range of 10-50 microns, and more preferably in the range of 10-15 microns.

The invention provides asymmetric membranes composed of a microporous substrate whose pores contain a crosslinked gel, the density of the crosslinked gel being greater at or adjacent to one major surface of the membrane than the density at the other major surface. The membranes are useful for separating matter from liquids and display good flux and good rejection at low pressure.

The invention provides asymmetric membranes composed of a microporous substrate whose pores contain a crosslinked gel, the density of the crosslinked gel being greater at or adjacent to one major surface of the membrane than the density at the other major surface. The membranes are useful for separating matter from liquids and display good flux and good rejection at low pressure.

Provided is a submerged arc welding method whereby: welds are provided with high toughness with low input heat; the heights of weld reinforcements can be reduced by minimizing melting that exceeds a requisite amount of wire; and deep penetration and a wide bead width can be obtained. The diameter of a first electrode wire at the head thereof in the welding direction is set at 2.0 to 3.2 mm, and the current density is at least 145 A / mm2. A second electrode onward is positioned in a single line behind the first electrode. The shape of a groove formed on a steel sheet is a two-level groove that satisfies [theta]B < [theta]T, where [theta]B represents a bottom-layer-side groove angle, and [theta]T represents a top-layer-side groove angle.

The invention discloses a construction method for single-side fusion-through welding of connection angle seams of closed longitudinal ribs and a bridge deck slab. The construction method comprises the following construction steps that the multiple closed longitudinal ribs and the bridge deck slab are assembled so that a bridge deck slab unit can be formed, the bridge deck slab unit is installed on a bed-jig of a slab unit welding production line horizontally, and welding backings are installed at the two inside longitudinal angle seams; the longitudinal angle seam located on the outer portion is welded by rotating the bed-jig; the other longitudinal angle seam located on the outer portion is welded by rotating the beg-jig; and the bed-jig is rotated to be in the horizontal state, and the bridge deck slab unit subjected to welding is removed. By means of the construction method, the problems that due to incomplete penetration of one-side welding of closed longitudinal ribs and a bridge deck slab, a fatigue crack source exists, and consequently fatigue cracks are caused can be solved, welding penetration of fillet welds of the closed longitudinal ribs can be effectively prevented, the effect that the depth of fusion of the fillet welds of the closed longitudinal ribs meets the design requirement can be ensured, full penetration and excellent molding of the fillet welds of the closed longitudinal ribs of a steel structure are achieved while the production efficiency is improved, and the service life of the steel structure is prolonged.

Provided is a submerged arc welding method enables welds with high toughness to be provided with low input heat, deep penetration, and a wide bead width to be sufficiently obtained in the welding of thick materials such that the welding speed is not more than 3 m / minute. The wire diameter of a first electrode at the head in the welding direction is established at 3.9 to 4.1 mm. Two electrodes are positioned on both sides of a weld line at the tail end in the welding direction. Wire tip positions of the two electrodes on the surface of a steel sheet are positioned on the same line, which is perpendicular to the weld line, and the distance (W) (mm) between the wire tip positions and the weld line is established at 5 to 20 mm.

The invention discloses an automobile front floor assembly, which is arranged between the engine room assembly and the rear floor assembly of the automobile, the assembly includes a front floor body, and the front floor body defines a central passage extending longitudinally of the automobile , the central channel protrudes toward the outside of the vehicle body, so that the cross-section of the front floor body is basically in the shape of an inverted "several". The central channel of the assembly of the present invention can provide more space for placing motorcycles, so that the front floor assembly is more suitable for Mocha models, and other structural changes on the assembly are small, the manufacture is simple, and the cost is saved.

A vibratory attachment interface enabling transmission of oscillations generated by an oscillation source upon an external human body surface. The interface comprises a first contact node and a second contact node slideably mounted alongside the first contact node, wherein the contact nodes are each sized and shaped to enable seating within a human rib-space, and whereby upon forced engagement of the first contact node within a first rib-space, the second contact node automatically slides and conforms to the contour of a second differing rib-space thereby optimally nestling within the second rib-space. The attachment interface is for use in contoured application to preferably the anatomic left sternal border, third and fourth intercostal space, such as to enable and ensure an optimized vibratory transmission pathway from the chest wall to the base of the heart and coronary arteries thereupon.

A measuring cell for a gas analysis spectrometer has an inner chamber for a sample gas to be analyzed and an inlet and an outlet which are connected thereto. A traversing optical path for a measuring beam is formed in the inner chamber. The measuring cell is tubular, the inlet and the outlet are arranged at opposite ends, and the inner chamber of the measuring cell has a cross-sectional shape that is monotonic over the length of the tube and which has an oval-shape at the start, which disappears toward the end. That special shape results in fast gas exchange and thus high dynamics, even with larger measuring cells, which have high sensitivity due to the long optical paths thereof. Two characteristics which until now appeared to be conflicting are thereby combined.

A motor vehicle front end and a method for producing a motor vehicle front end are provided in accordance with embodiments of the invention. The motor vehicle front end has a front wall and the front wall girder, the front wall girder essentially being situated in the direction of a vehicle transverse axis. In addition, the motor vehicle front end has a first front wall girder, the first front wall girder being situated essentially in the direction of a vehicle vertical axis. The first front wall girder is supported on the front wall crossbeam in a first area of the front wall crossbeam.

A membrane-electrode assembly (MEA) including a membrane and two electrodes, and further at least one layer located at the interface of the membrane and of an electrode. The layer contains a proton conductive polymer which has a glass transition temperature lower than or equal to, advantageously lower than, that of the proton conductive polymer contained in the membrane.