76 results about "Antipruritic agents" patented technology

A topical spray or foam, methods of making the formulation, and methods of use thereof, has been developed. In one preferred embodiment, the composition includes one or more active agents and exhibits both antibacterial activity and antifungal activity. Excipients such as chemical disinfectants, anti-pruritic agents to minimize itching, and skin protective compounds may be added. The composition may be formulated to be dispensed as a spray or foam and the spray or foam may be administered either by a hand pump or by an aerosolizing propellant. A second single phase formulation has also been developed. The formulation comprises a first drug which is water soluble or hydrophilic and a second drug which is lipid soluble or hydrophobic, wherein at least one of the drugs is bound to an ion-exchange resin. The use of binding resins, such as ion-exchange resins, allows drugs with incompatible solvent requirements to be prepared in a single-phase formulation.

The present invention provides a non-water soluble, film-forming composition which adheres to body tissue and forms a pharmaceutical carrier to provide localized delivery of an antifungal agent to a treatment site. The composition will typically include: (a) an alkyl cellulose; (b) a hydroxyalkyl cellulose; (c) a pharmaceutically acceptable polar protic solvent; (d) an antifungal agent selected from the group of naftifine, ciclopirox, terbinafine, pharmaceutically acceptable salts thereof, and combinations thereof; (e) an glycol ether; (f) an antipruritic agent selected from the group of camphor, menthol, butamben picrate, metacresol, benzyl alcohol, camphorated metacresol, juniper tar, phenol, phenolate sodium, resorcinol, camphorated metacresol, carbolic acid, and combinations,; and (g) a solubility enhancing agent, a surfactant, a wetting agent, or a combination thereof. The present invention also provides for the use of the composition composition of the present invention, in treating a fungal infection (e.g., nail fungus) in a mammal afflicted with such an infection.

The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical compositions comprising NK-1 receptor antagonists such as serlopitant. In addition, the invention encompasses treatment of a pruritus-associated condition with serlopitant and an additional antipruritic agent, and the use of serlopitant as a sleep aid, optionally in combination with an additional sleep-aiding agent.

An object of the present invention is to provide an antipruritic agent having a novel action mechanism. The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A1 and A2 represent a single bond or an alkylene group; E represents —NHCO—; A3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R3 represents a non-cyclic aliphatic hydrocarbon group; and R4 and R5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.

The invention relates to a cooling and itching relieving composition which comprises at least one antipruritic agent, at least one freshener and at least one transdermal enhancer, wherein the mass ratio of the antipruritic agent to the freshener to the transdermal enhancer is 0.1-20 to 0.1-30 to 30-80; the percentage by mass of a hydrophobic lipophilic substance in the cooling and itching relieving composition reaches at least 60 percent. The invention also provides a paper towel applying the cooling and itching relieving composition. The cooling and itching relieving composition disclosed by the invention is prepared by selecting the antipruritic agent, the freshener and the transdermal enhancer according to a specific ratio and takes good cooling and itching relieving effects. Moreover, when the cooling and itching relieving composition disclosed by the invention is transferred to the surface of paper, a plurality of points distributed at intervals are formed on the surface of the paper, so that when the paper is used for wiping the skin, the cooling and itching relieving composition on the paper is very easy to transfer onto the skin.

A removal system for sewn-in hair extensions, hair weaves, hair augmentation, and wigs is disclosed. This invention solves issues with respect to facile removal and scalp irritation caused by such extensions through the use of methods using dissolvable thread and dissolving agent, with optional added antipruritic and anti-itch properties or by adding a separate antipruritic agent. The dissolvable thread may be used to either secure hair extension wefts to a wearer's hair or in conjunction with a hair weft constructed of the same dissolvable material comprising the thread.

The invention belongs to the technical field of daily chemical products and particularly relates to scalp caring composition and a preparation method thereof. The scalp caring composition is preparedfrom, in percentage by weight, 1%-40% of a surfactant, 0.1%-5% of a relieving antipruritic agent, 0.1%-10% of an aid and the balance of pure water. The components of the scalp caring composition are mild and not irritating, scalp and hair follicles can be effectively relieved while the scalp is mildly cleaned, and the problems of scalp irritation, heavy load and excessive deposition caused by traditional hair cleaning are solved. Water-soluble oil and water-based macromolecular film forming agents contained in the scalp caring composition can form protection layers on the scalp effectively, irritation to the scalp and excessive deposition of harmful substances (such as macromolecular silicone oil and the like) or irritation of the outside environment to the scalp can be prevented during hair cleaning, and the irritation of the product is substantially reduced.

The invention relates to the field of daily chemicals and in particular relates to a shampoo composition. The shampoo composition comprises the following components: imidazoline surfactants, amino acid surfactants, cation quaternary fructooligosaccharides, plant amino acids and water. The weight of the imidazoline surfactants accounts for 0.01% to 10% of the total weight of the shampoo composition, the weight of the amino acid surfactants accounts for 0.01% to 10% of the total weight of the shampoo composition, the weight of the cation quaternary fructooligosaccharides accounts for 0.01% to 5% of the total weight of the shampoo composition, and the weight of the plant amino acids accounts for 0.01% to 5% of the total weight of the shampoo composition. The shampoo composition further comprises surfactants, non-volatile siloxane, cation polymers, suspension stabilizers, additives and optionally anti-dandruff and antipruritic agents. The shampoo composition causes less irritation to the scalp and enhances conditioning property of the scalp.

External preparations for treating pruritus containing Aspirin as an active ingredient, which exert an excellent therapeutic effects on pruritus with less side effects.

The present invention is directed to a composition that is suitable for the treatment of wounds and other dermatological conditions. The composition of the present invention comprises an anesthetic agent; an antipruritic agent; a mitotic agent; vitamin D or a derivative thereof; at least one of peppermint oil and thyme oil; one or more antioxidant agents; and a pharmaceutically acceptable carrier. The composition may further comprise one or more humectants and / or one or more emollients.

The invention provides bacteria-inhibiting and itching-relieving cream for external application of skin, a preparation method and an application thereof. The bacteria-inhibiting and itching-relieving cream comprises the following raw materials in percentage by mass: 1-3 percent of emulsifier, 1-10 percent of mixed alcohol, 1-3 percent of glycerin monostearate, 6-10 percent of mineral oil, 1-6 percent of propylene glycol, 0.001-0.01 percent of an antibacterial agent quaternary ammonium salt-73, 0.02-0.15 percent of an antipruritic agent dihydro-oat acyl o-aminobenzoic acid D and the balance of water. The preparation method comprises the following steps: pre-dissolving an antibacterial agent and an antipruritic; preparing a B-phase material containing glycerinum; preparing an A-phase material consisting of the emulsifier, the mixed alcohol, the glycerin monostearate and Vaseline; heating and mixing the B-phase material and the A-phase material, and stirring; and adding a C-phase material, and uniformly stirring. The cream does not contain antibiotics and corticosteroids (steroid hormone), has a remarkable effect of inhibiting bacteria and relieving itching, and is safe to use.

A pharmaceutical preparation for preventing or treating pruritic symptoms which contains as an effective ingredient a prostaglandin derivative represented by formula [1]wherein X1 and X2 which are different from each other represent a hydrogen atom, a halogen atom or a hydroxyl group; Y is an ethylene group, a vinylene group or an ethynylene group; Z is the formula (CH2)kA(CH2)hB(CH2)q, (CH2)kA(CH2)rA′(CH2)t (CH2)kB(CH2)hB′(CH2)q or (CH2)k-1B′(CH2)q-1A′wherein k is an integer of 1 to 4, h is an integer of 0 to 4, q is an integer 1 to 4, r is an integer of 0 to 4, and t is an integer of 0 to 2; A and A′ which may be the same or different represent an ethylene group, a vinylene group or an ethynylene group; B and B′ which may be the same or different represent an oxygen atom or a group represented by the formula S(O)u wherein u is an integer of 0 to 2; W1 is a hydroxyl group, a C1-10 alkyloxy group, a C3-10 cycloalkyloxy group, an aryloxy group or an arylalkyloxy group; W2 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, a C3-10 cycloalkyl group, a C1-5 alkyl group substituted by C3-10 cycloalkyl group(s), or a group represented by the formula wherein W4 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group or a C1-5 alkyl group substituted by C3-10 cycloalkyl group(s); v is an integer of 0 to 4; W3 is a hydrogen atom or a methyl group, or W3 when taken together with W2 and the adjacent carbon atom forms a C3-10 cycloalkyl group; m is 0 or 1, a pharmaceutically acceptable salt thereof or a hydrate thereof.

The invention provides a no-wash type female care solution and a preparation method thereof, and belongs to the technical field of daily care supplies. The no-wash type female care solution is obtained by fully dissolving a plant nourishing soft and moist agent, a plant bacteriostasis odor removing agent, a plant anti-allergy antipruritic agent, a microorganism modifier, plant hydrolat, citric acid, sodium citrate and the like into solvent. The no-wash type female care solution has the advantages that the skin of the private parts of women can be effectively moistened and cured, the female care solution can be absorbed by the skin easily, a compound surface active agent is not included, manual essence is not added, a manual synthetic product is not added, and the formula is safe; in particular, the spraying mode can be used during application, a traditional washing or lavage mode is needless, and convenience and rapidness are achieved.

The invention relates to the technical field of biological medicines and particularly relates to a silicone gel capable of removing a scar and a preparation method of the silicone gel. The silicone gel is prepared from the following raw materials in parts by weight: 1-10 parts of dimethyl silicone oil, 10-30 parts of hexamethyldisiloxane, 20-60 parts of a polydimethylsiloxane self-crosslinking polymer, 0-10 parts of a natural plant antimicrobial agent and 0-5 parts of an antipruritic agent. The dimethyl silicone oil and the polydimethylsiloxane self-crosslinking polymer can be quickly crosslinked and combined with other components under the action of the hexamethyldisiloxane and the hexamethyldisiloxane has high volatility, is capable of quickly promoting various substances to form a thin film after being crosslinked and combined, and is well tightly laminated with epidermis; hydration of skin is ensured; the silicone gel has the effects of smoothing and softening scars caused by various external causes; and meanwhile, various components work together, so that scar hyperpigmentation is significantly improved and the symptoms such as pruritus and erythema are improved.

The invention provides a preparation method and application of a mosquito repellent wet tissue and a stock solution thereof, and relates to the technical field of daily chemicals. The stock solution of the mosquito repellent wet tissue comprises a mosquito repellent essential oil, an antipruritic, a sustained-releasing agent, a solvent, a humectant, an emulsifier, a preservative and water. According to cooperation of the specific components and the proportion of the stock solution of the mosquito repellent wet tissue, an effective and long-acting mosquito repellent effect can be achieved and has a remarkable relieving effect on symptoms after mosquitoes bite. The preparation method of the stock solution of the mosquito repellent wet tissue provided by the invention comprises the steps of respectively preparing a sustained-releasing stock solution and a functional stock solution and mixing the sustained-releasing stock solution with the functional stock solution. According to the preparation method, the sustained-releasing stock solution and the functional stock solution are prepared respectively, and then the sustained-releasing stock solution and the functional stock solution aremixed, so that the wrapping rate of the sustained-releasing material on effective ingredients can be effectively improved, and the effective mosquito-repellent time of the mosquito-repellent wet tissue can be effectively prolonged on the basis of saving the raw material cost. The mosquito repellent wet tissue provided by the invention is convenient to carry, remarkable in effect and wide in protection range.

The present invention relates to an antipruritic agent comprising a nociceptin antagonist as an active ingredient. The nociceptin antagonist can be used as a preventive or remedy for diseases associated with itching (for example, atopic dermatitis and urticaria), local pruritus cutaneous caused by insect excretion and secretion, nodular prurigo, kidney dialysis, diabetes, blood disease, liver disease, kidney disease, incretion and metabolic disorder, viscera malignant tumor, hyperthyroidism, autoimmune disease, multiple sclerosis, neurologic disease, psychoneurosis, allergic conjunctivitis, spring catarrh, atopic keratoconjunctivitis, or itching caused by excess use of laxuries and drugs because it has excellent scrtaching behavior suppressing effect, that is, antiitching effect and antipruritic effect.

The invention belongs to the technical field of daily supplies, and particularly relates to multiple-effect anti-hair loss shampoo and a preparation method thereof. The multiple-effect anti-hair lossshampoo is prepared from a multiple-effect anti-hair loss extracting solution, a foaming agent, a thickening agent, a conditioner, an acidity regulator, an antipruritic agent, a viscosity regulator, amoisturizing agent, a preservative, essence and water. The multiple-effect anti-hair loss shampoo adopts a natural medicinal plant formula, various active traditional Chinese medicine essence ingredients are fused, special effects of Chinese herbal medicines are fully given play to, the shampoo can be quickly absorbed by hair follicles, the shampoo does not irritate hair and does not damage the hair, the shampoo can be quickly absorbed deep in the hair follicles, blood circulation of the scalp is promoted, the life vigor of the hair follicles is kept, and the shampoo has the advantages of caring the hair and continuously improving hair loss and is suitable for various kinds of hair-loss people.

The invention relates to a manufacturing method of antipruritic toilet paper. A large roll of toilet paper is produced by a common paper technology, and is subjected to the procedures of spraying of antipruritic agent, back-rolling, cutting and sealed package into small rolls. The antipruritic agent is prepared from A and B components, wherein the A component comprises the following materials in parts by weight: 98-99 parts of aqueous solution containing 0.1%-0.5% of polyving akohol, 0.5-1 part of natural perfume, 0.1-0.2 part of protease, 0.1-0.5 part of diastasum diastace, 1-3 part(s) of coptisine chloride and 1-2 part(s) of borneol; and the B component is traditional Chinese medicine paste and comprises the following materials in parts by weight: 8-15 parts of radix sophorae flavescentis, 8-15 parts of fructus cnidii, 8-15 parts of fructus kochiae, 6-13 parts of scutellaria baicalensis, 3-8 parts of golden cypress, 3-8 parts of fructus forsythia, 6-13 parts of viola yedoensis, 3-9 parts of schizonepeta, 3-8 parts of radices sileris, 6-13 parts of root of common peony, 3-8 parts of angelica sinensis and 3-8 parts of folium artemisiae argyi. Five thousand parts of water are added to the components A and B for extraction, and 200g of traditional Chinese medicine paste is obtained in filtering and concentrating manners. The product is soft in character and good in toughness, and is taken as the antipruritic toilet paper.

The invention relates to the field of daily chemicals, in particular to a toner for children. The toner for children comprises the following components in percent by weight: 0.5-5.0% of a moisturizer, 0.1-1% of an additive, 0.0005-0.005% of active matters, 0.1-1% of an anti-allergy agent, 0.5-5% of an antipruritic, and 0-0.5% of a preservative, and the balance of water, wherein the total percentage of all the components is 100%. The invention provides the comfortable toner which is specially designed for tender skin of children, can effectively relieve itchy feeling, facilitates the fading of miliaria, further, and can gently recover skin scratched by children, so that children can recover to feel comfortable and be healthy.

The invention discloses a shampoo with oil balancing, anti-bacteria, anti-inflammation and scalp repairing effects. The shampoo with oil balancing, anti-bacteria, anti-inflammation and scalp repairingeffects comprises the following components in parts by mass: 100-200 parts of water, 25-46 parts of a surfactant, 3.5-10 parts of a grease enriching agent, 1.05-2.5 parts of a hair repairing agent and a gloss agent, 2-4 parts of a softener, 0.02-0.05 part of a PH adjusting agent, 0.05-0.1 part of a chelating agent, 0.1-0.5 part of a freshener, 0.5-1.5 part of a preservative, 1-2 parts of a flavouring agent, 10-35 parts of traditional Chinese medicine factors, 0.5-1.5 part of an anti-dangdruff and antipruritic agent and 6-16 parts of a skin conditioning, anti-aging and repairing agent. Throughadoption of the components, the shampoo has the oil balancing, anti-bacteria, anti-inflammation and scalp repairing effects so as to achieve a mild, safe, efficient and lasting anti-dangdruff effect.

The present invention relates to an antipruritic agent comprising a nociceptin antagonist as an active ingredient. The nociceptin antagonist can be used as a preventive or remedy for diseases associated with itching (for example, atopic dermatitis and urticaria), local pruritus cutaneous caused by insect excretion and secretion, nodular prurigo, kidney dialysis, diabetes, blood disease, liver disease, kidney disease, incretion and metabolic disorder, viscera malignant tumor, hyperthyroidism, autoimmune disease, multiple sclerosis, neurologic disease, psychoneurosis, allergic conjunctivitis, spring catarrh, atopic keratoconjunctivitis, or itching caused by excess use of laxuries and drugs because it has excellent scratching behavior suppressing effect, that is, antiitching effect and antipruritic effect.

The invention discloses a plant mosquito-dispelling cooling and itching-relieving composition and a preparation method thereof. The composition comprises the following components in percentage by weight: 10 to 23 percent of ethanol, 0.1 to 0.5 percent of a mint derivative, 0.1 to 1 percent of an anti-inflammatory antipruritic agent, 0.5 to 10 percent of a humectant, 0.05 to 1 percent of a plant mosquito repellent, 0.2 to 4 percent of a solubilizer, 0.1 to 4 percent of other components and the balance of deionized water. According to the invention, the anti-inflammatory and antipruritic agent is matched with a small amount of the mint derivative, so that the anti-inflammatory and antipruritic effect is remarkable and mild, and the skin is not stimulated and feels cool and comfortable. The ethanol content is far lower than the ethanol content of traditional floral water, so that the plant mosquito-dispelling cooling and itching-relieving composition belongs to a non-dangerous article, has obviously improved use safety in flammability and explosibility, and is convenient to carry. The plant natural mosquito removing essential oil not only can remove mosquitoes, but also has fragrant smell, and is fresh and pleasant.

The invention discloses tea bran anti-dandruff itching-relieving shampoo and a preparation method thereof. The shampoo is mainly prepared from the following raw materials in parts by weight: 10 to 50parts of tea bran, 2 to 10 parts of Chinese honeylocust fruit, 1 to 6 parts of radix polygoni multiflori, 1 to 20 parts of a thickening agent, 6 to 26 parts of a foaming agent, 0.02 to 0.12 part of anitching relieving agent, 0.2 to 1.5 parts of nutritional ingredients, 0.03 to 0.15 part of hyaluronic acid, 0.2 to 1.6 parts of citric acid, 0.02 to 1 part of edible oil, 0.02 to 0.6 part of essenceand 100 to 120 parts of water. Mulberry leaves adopted by the invention have better effects of dispelling wind and heat, clearing the lung and moistening dryness, and clearing the liver and improvingeyesight, cortex dictamni has better effects of clearing heat and drying dampness, and dispelling wind and removing toxicity, fructus viticis has better effects of dispelling wind and heat, clearing head and eyes and dehumidifying joints, cacumen biotae can better prevent blood-heat alopecia and premature graying of hair, the tea bran contains tea saponin, protein, natural tea oil and the like, and the shampoo has the effects of stopping dandruff, relieving itching, removing oil, realizing sterilization and repairing damaged hair after being used for a long time, and is beneficial to use.

A removal system for sewn-in hair extensions, hair weaves, hair augmentation, and wigs is disclosed. This invention solves issues with respect to facile removal and scalp irritation caused by such extensions through the use of methods using dissolvable thread and dissolving agent, with optional added antipruritic and anti-itch properties or by adding a separate antipruritic agent. The dissolvable thread may be used to either secure hair extension wefts to a wearer's hair or in conjunction with a hair weft constructed of the same dissolvable material comprising the thread.

The invention provides a pain therapy cream comprising an anhydrous topical delivery formulation for percutaneous absorption comprising an anhydrous carrier medium, a chemical exfoliant, a penetration enhancer, and one or more pain killing agent selected from the group consisting of an analgesic, anesthetic, anti-inflammatory, or antipruritic agent, a phytochemical and other painkilling active ingredients, and methods of using the pain therapy cream.

The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical compositions comprising NK-1 receptor antagonists such as serlopitant. In addition, the invention encompasses treatment of a pruritus-associated condition with serlopitant and an additional antipruritic agent, and the use of serlopitant as a sleep aid, optionally in combination with an additional sleep-aiding agent.