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Compound terbinafine nanomedicine for treating skin diseases and preparation method thereof

A technology of compound terbinafine and nano-medicine, which is applied in the field of medicine, can solve the problems of single function, unstable physical properties, and large toxic and side effects of pets, and achieve the effects of high bioavailability, clear and transparent appearance, and simple preparation process

Inactive Publication Date: 2012-07-25
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above three drugs have poor solubility and unstable physical properties. They cannot comprehensively prevent and treat pet skin diseases caused by various reasons. They need to be administered multiple times at the same time to achieve the therapeutic effect.
At present, there are ivermectin, metronidazole, lincomycin, doramectin, etc. on the market for the treatment of pet skin diseases, but the above-mentioned products have single functions and are inconvenient to use. Toxic to pets

Method used

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  • Compound terbinafine nanomedicine for treating skin diseases and preparation method thereof
  • Compound terbinafine nanomedicine for treating skin diseases and preparation method thereof
  • Compound terbinafine nanomedicine for treating skin diseases and preparation method thereof

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Effect test

Embodiment 1

[0066] 1) Add 0.02g terbinafine, 0.02g eugenol and 0.01g erythromycin to 0.6g ethylene glycol to dissolve completely;

[0067] 2) Add 0.8g of ethyl acetate to the solution prepared in step 1) and stir evenly;

[0068] 3) Then add 3g Tween-80 to the solution prepared in step 2), stir evenly, slowly add 5.55g distilled water at 20°C and stir thoroughly until a clear, transparent, yellow or colorless transparent compound with low viscosity and fluidity is formed Terbinafine Nanoemulsion.

Embodiment 2

[0070] Terbinafine 0.6g, eugenol 0.1g, erythromycin 0.1g, triacetin 0.2g, Tween-80 2g, absolute ethanol 1g, distilled water 6g.

Embodiment 3

[0072] Terbinafine 0.05g, eugenol 1.2g, erythromycin 0.05g, ethyl acetate 0.2g, Tween-80 1g, absolute ethanol 1g, distilled water 6.5g.

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Abstract

The invention discloses a compound terbinafine nanomedicine used for treating skin diseases. The grain size of the medicine is 1nm-10nm, and the compound terbinafine nanomedicine comprises the following components: 0.1%-10% of terbinafine, 0.1%-15% of eugenol, 0.1%-5% of erythromycin, 0.1%-10% of oil, 10%-40% of surfactant, 4%-20% of cosurfactant and the balance of distilled water, and the total percentage by weight of the components is 100%. The medicine disclosed by the invention has the advantages of small particle size, low viscosity, good liquidity, stable properties and better percutaneous permeability, and not only has a stronger curative effect on pet dermatomycosis, but also has a strong therapeutical effect on pet bacterial skin diseases and parasitic skin diseases. The compound terbinafine nanomedicine disclosed by the invention is easy to prepare, is low in energy consumption, and can be in mass production without special equipment. The compound terbinafine nanomedicine has wide application prospects in the aspect of pet skin disease treatment.

Description

technical field [0001] The invention belongs to the field of medicine, relates to a new dosage form of a compound drug, in particular to a preparation method of a stable and transparent compound terbinafine nano-medicine for treating skin diseases. Background technique [0002] Terbinafine is a new generation of broad-spectrum antifungal allylamine drugs. It is a white or off-white crystalline powder, insoluble in water but soluble in organic solvents. Its outstanding advantage is that it has dual functions of bactericidal and bacteriostatic, mainly by inhibiting fungal squalene cyclooxygenase, leading to the accumulation of squalene, lipid droplets deposited in the cell wall and cytoplasm, causing cell membrane rupture to achieve the purpose of sterilization ; Secondly, it can lead to the lack of ergosterol, the growth of the fungal cell membrane is disturbed, the fungus stops growing, and the purpose of antibacterial is achieved. Terbinafine has a strong antibacterial eff...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/16A61K31/137A61K9/107A61P17/00A61P31/04A61P31/10A61P33/00
Inventor 欧阳五庆刘梅雪欧阳伸雨
Owner NORTHWEST A & F UNIV
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