Methods and compositions are provided which contains preparations of
calcium chelators, bisphosphonates,
antibiotics,
antimicrobial agents,
cytostatic agents,
calcium ATPase and
pyrophosphatase pump inhibitors,
calcium phosphate-
crystal dissolving agents, agents effective against calcium
phosphate-
crystal nucleation and
crystal growth, and / or a combination of supportive agents and which may be used for treating and or reducing
pathological calcifications, the growth of Nanobacterium and
calcification-induced diseases including, but not limited to,
Arteriosclerosis, Atherosclerosis,
Coronary Heart Disease, Chronic
Heart Failure, Valve Calcifications,
Arterial Aneurysms, Calcific Aortic
Stenosis, Transient Cerebral
Ischemia,
Stroke,
Peripheral Vascular Disease,
Vascular Thrombosis,
Dental Plaque, Gum
Disease (dental pulp stones), Salivary Gland Stones,
Chronic Infection Syndromes such as
Chronic Fatigue Syndrome,
Kidney and
Bladder Stones,
Gall Stones,
Pancreas and Bowel Diseases (such as
Pancreatic Duct Stones, Crohn's
Disease,
Colitis Ulcerosa), Liver Diseases (such as Liver
Cirrhosis, Liver Cysts), Testicular Microliths, Chronic Calculous
Prostatitis,
Prostate Calcification,
Calcification in
Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma,
Dermatomyositis, Antiphospholipid Syndrome,
Arteritis Nodosa, Thrombocytopenia,
Hemolytic Anemia,
Myelitis, Livedo Reticularis,
Chorea,
Migraine,
Juvenile Dermatomyositis, Grave's
Disease, Hypothyreoidism, Type 1
Diabetes Mellitus, Addison's Disease, Hypopituitarism, Placental and Fetal Disorders,
Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as Corneal Calcifications,
Cataracts,
Macular Degeneration and
Retinal Vasculature-derived Processes and other
Retinal Degenerations,
Retinal Nerve Degeneration,
Retinitis, and Iritis), Ear Diseases (such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and
Inner Ear (Vertigo and
Tinnitus)), Thyroglossal Cysts,
Thyroid Cysts, Ovarian Cysts,
Cancer (such as Meningiomas,
Breast Cancer,
Prostate Cancer,
Thyroid Cancer, Serous Ovarian
Adenocarcinoma),
Skin Diseases (such as Calcinosis
Cutis, Calciphylaxis,
Psoriasis, Eczema,
Lichen Ruber Planus),
Rheumatoid Arthritis, Calcific Tenditis,
Osteoarthritis,
Fibromyalgia,
Bone Spurs, Diffuse Interstitial Skeletal
Hyperostosis, Intracranial Calcifications (such as
Degenerative Disease Processes and
Dementia), Erythrocyte-Related Diseases involving
Anemia, Intraerythrocytic Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive
Pulmonary Disease, Broncholiths, Bronchial Stones, Neuropathy,
Calcification and Encrustations of Implants, Mixed Calcified Biofilms, and Myelodegenerative Disorders (such as
Multiple Sclerosis, Lou Gehrig's and Alzheimer's Disease) in humans and animals. The method comprises administering the various classes of compositions of the present invention, which together effectively inhibit or treat the development of calcifications
in vivo.