2 results about "Microvascular complication" patented technology

The invention relates to the technical field of diabetic hypoglycemia, and discloses a diabetic hypoglycemia response induced vascular injury biomarker which is a combination of high-sensitivity C reactive protein, 8-isoprostaglandin F2alpha, von willebrand factor, free fatty acid and D-dimer. The invention further discloses application of the diabetic hypoglycemic response induced vascular injury biomarker in preparation of a reagent for early auxiliary diagnosis of diabetic hypoglycemic response induced vascular injury. According to the invention, a combination of high-sensitivity C-reactive protein, 8-isoprostaglandin F2alpha, von willebrand factor, free fatty acid and D-dimer is used as a vascular injury biomarker induced by diabetes mellitus hypoglycemia response; acute vascular dysfunction, cardiovascular system injury, microvascular complications and atherosclerosis can be effectively diagnosed, diabetic vasculopathy can be found at an early stage, disease progression can be predicted, and clinical treatment can be guided; the sensitivity and the specificity are high.

The application discloses a kind of informationization quantification evaluation methods of the progress trend of diabetic microvascular complications, belong to biomedical signal processing field, including, step 1, identify the point of slope in blood glucose sequence exceeds predetermined slope threshold as incentive anchor point, search microvessel response point in preset time window, the response value of this point exceeds predetermined deviation threshold relative to the offset of baseline before excitation, and it is as response anchor point, output the time difference between incentive anchor point and response anchor point as original time offset;Step 2, based on double exponential decay recovery model from original time offset, response measurement and baseline value before excitation;The present application can realize by accurate identification of subclinical stage microvessel occult injury, effectively avoid subclinical progress period patient misjudgment as low-risk population, provide reliable data support for early intervention of microvascular complications, improve the timeliness and effectiveness of early intervention.