Composition containing piperacillin, its pharmaceutical preparation and its application

A technology for piperacillin and pharmaceutical preparations, applied in the field of compositions containing piperacillin, capable of solving the problems of drug resistance of Acinetobacter baumannii

Active Publication Date: 2021-05-14
XIANGBEI WELMAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the invention is to solve the problem of drug resistance of Acinetobacter baumannii, especially the problem of drug resistance of Acinetobacter baumannii to cefoperazone sulbactam

Method used

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  • Composition containing piperacillin, its pharmaceutical preparation and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 piperacillin composition

[0021] Take piperacillin sodium (1000g as piperacillin acid), ampicillin sodium (0.1g as ampicillin acid) and sulbactam sodium (500g as sulbactam acid), and use a single cone ribbon mixer Thoroughly mix the three materials evenly to obtain a composition. A part of the composition is taken and subpackaged under aseptic conditions to obtain injections in the form of dry powder (sterile powder for injection). Another part of the composition was dissolved with 100 times the amount (ml / g) of 0.9% sodium chloride aqueous solution and subpackaged to obtain an injection in the form of a solution.

Embodiment 2

[0022] The preparation of embodiment 2 piperacillin composition

[0023] Get piperacillin acid 1000g, ampicillin acid 0.3g and sulbactam acid 500g, after dissolving with the aqueous solution that contains 343g sodium bicarbonate, lyophilize, pack, obtain a kind of dry powder form injection (freeze-dried powder) that contains composition Needle).

Embodiment 3-6

[0024] The preparation of embodiment 3-6 piperacillin composition

[0025] The operation of embodiment 3-6 is similar to embodiment 1, and the amount of piperacillin and sulbactam is identical with embodiment 1, and difference is that the consumption of ampicillin increases gradually in each embodiment, is respectively 1g, 3g, 10g and 15g.

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Abstract

The invention provides a piperacillin-containing composition. The composition contains piperacillin and a certain proportion of ampicillin and sulbactam. The invention also provides its pharmaceutical preparation and application. Compositions and pharmaceutical preparations of the present invention can significantly inhibit drug-resistant Acinetobacter baumannii, especially to carbapenem antibiotics or cefoperazone-sulbactam-resistant Acinetobacter baumannii infection can play a significant role. Good therapeutic effect, with significant clinical advantages.

Description

technical field [0001] The invention relates to a composition containing piperacillin and its application. Background technique [0002] Acinetobacter baumannii is an important pathogen that can cause infections in the respiratory, blood, abdominal cavity, central nervous system, urinary and skin soft tissue systems. According to the 2016 report of China Bacterial Resistance Monitoring (CHINET), Acinetobacter baumannii is the pathogen with the highest proportion in respiratory specimens, suggesting that this bacteria has a very important impact on respiratory diseases. Especially for long-term hospitalized critically ill patients, pulmonary infection caused by Acinetobacter baumannii has become an important cause of death. In addition, among all clinical isolates, Acinetobacter baumannii accounted for as high as 10.8%, second only to Escherichia coli and Klebsiella pneumoniae. [0003] For a long time, penem-like carbapenem antibiotics have a good effect on Acinetobacter b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K31/43A61P31/04
CPCA61K31/43A61K31/496A61K2300/00
Inventor 孙天宇
Owner XIANGBEI WELMAN PHARMA CO LTD
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