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Oral preparation containing cefoperazone and its making method

A technology of cefoperazone and preparation, applied in the field of therapeutic drugs and preparation thereof, can solve the problems of low blood drug concentration, influence effective antibacterial efficacy, easily cause local pain reaction and the like, and achieve the effect of rapid onset of action

Inactive Publication Date: 2007-04-04
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the inconvenient use of injections and the tendency to cause local pain reactions when administered, at the same time, the drug is diluted in the blood through systemic distribution after injection into the blood, so that the blood drug concentration of the drug in the lesion is low, and the effective blood concentration in the lesion is reached. The time of drug concentration is also longer, which affects its effective antibacterial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 - Cefoperazone Candy

[0055] Prescription: 125g of cefoperazone sodium, 853g of sucrose, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, 2g of carbomer 934P, and the dosage is 1000 tablets.

[0056] Method: Prepare 125g of cefoperazone sodium, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P, grind it, and pass it through a 20-mesh sieve. Take 853 grams of sucrose, heat to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, put it on a product forming machine and extrude, each lozenge weighs 1 gram. Then measure the disintegration time limit of cefoperazone sodium candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0057] Results: The disintegration time limit is 6-10 minutes, and the dissolution rate is 90%-99% when completely disintegrated.

Embodiment 2

[0058] Embodiment 2-low sugar cefoperazone candy (1)

[0059] Prescription: Cefoperazone sodium 125g, sucrose 203g, fructooligosaccharides 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g, preparation dose 1000 tablets.

[0060] Method: Prepare 125g of cefoperazone sodium, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P, grind it, and pass it through a 20-mesh sieve. Take 203g of sucrose, 300g of fructo-oligosaccharide, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, cool to 85°C, add 125g of sieved cefoperazone sodium, stir rapidly for 10 minutes, put it on the product forming machine and extrude Pressed into shape, each lozenge weighs 1 gram. Then measure the disintegration time limit of cefoperazone sodium candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0061] Results: The disintegration time limit is 8-12 minutes, and the ...

Embodiment 3

[0062] Embodiment 3-low sugar cefoperazone buccal tablet (1)

[0063] Prescription: Cefoperazone sodium 125g, gelatin 240g, glycerin 60g, water 60g, fructooligosaccharides 133g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, magnesium stearate 10g, calorie Bohm 934P 2g, the dosage is 1000 tablets.

[0064] Method: prepare gelatin 240g, glycerin 60g, water 60g mixed matrix, dry, then add cefoperazone sodium 125g, fructo-oligosaccharide 133g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, Carbomer 934P 2g mixture, ground, passed through a 20-mesh sieve, granulated with ethanol and water, dried at 60°C, then added with 10 grams of magnesium stearate, mixed evenly, placed on a tablet machine and extruded, each lozenge Weighs 1 gram. Then measure the disintegration time limit of cefoperazone sodium buccal tablet in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0065] Results: The disi...

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PUM

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Abstract

An orally absorbed medicine in the form of buccal lozenge, sweets, or dripping pill dissolved by saliva features that it contains cefoperazone. Its preparing process is also disclosed.

Description

[0001] [Technical field] The present invention relates to a kind of therapeutic medicine and its preparation method, especially the buccal preparation containing cefoperazone and its preparation method. [Background technique] [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by group A stre...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/20A61K9/48A61K31/546A61P31/04
Inventor 刘凤鸣
Owner 刘凤鸣
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