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Slow released capsule of cefoperazone and bletilla tuber glue for animal and birds

A cefoperazone and bioadhesion technology, which is applied in the preparation of veterinary drug cefoperazone bletilla gum bioadhesion sustained-release capsules and the field of preparation thereof, can solve the problems of unsatisfactory adhesion and drug release performance, threat of dangerous diseases, safety It can improve the effect of drug treatment, improve the therapeutic effect, and improve the bioavailability.

Inactive Publication Date: 2007-06-27
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main problems of animal products in my country are: first, the threat of dangerous diseases; second, drug residues
Natural materials are non-toxic and have good biocompatibility, but their adhesion and drug release properties are not ideal; synthetic materials have better adhesion and drug release properties, but are expensive and unsatisfactory in safety
Therefore, currently few bioadhesive materials fully meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of Cefoperazone Bletilla Gum Bioadhesive Sustained Release Capsules

[0014] a. Preparation of Bletilla striata glue: 5kg of Bletilla striata, crushed, added 40L of distilled water, heated in a water bath at 60°C to keep warm and impregnated, stirred, the extract was filtered through four layers of gauze, the dregs were added with distilled water, repeatedly impregnated, the filtrate was combined several times, concentrated, Add 95% ethanol to make the alcohol content reach 70%, precipitate a large amount of white flocculent precipitate, let it stand overnight, filter the next day, recover ethanol, collect the precipitate, wash with ethanol for 3 times, evaporate the ethanol, and dry it at about 80°C , weighed, and pulverized to obtain 1.1kg of Bletilla striata gum; Bletilla striata gum: its properties are yellow dry powder, tasteless and odorless, insoluble in ethanol, soluble in water, and in the form of a thick colloid. α-Naphthol concentrated ...

Embodiment 2

[0016] Example 2: The prepared Cefoperazone Bletilla Gum Bioadhesive Sustained-release Capsules were used to treat respiratory tract, urinary tract, biliary tract, intestinal tract and other infections caused by most Gram-negative bacteria in livestock and poultry. The administration method is mixing or drinking water administration, poultry 0.05-0.15g / kg body weight, livestock 0.03-0.06g / kg body weight, twice a day, 3-5 days as a course of treatment.

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PUM

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Abstract

The present invention belongs to the field of veterinary medicine technology, and is especially slow released veterinary medicine capsule prepared with cefoperazone and bletilla tuber as material. The preparation process includes the following steps: water extracting and alcohol precipitation to extract bletilla tuber glue; mixing cefoperazone and bletilla tuber in the ratio of 1 to 3 and 10 % concentration alcohol solution of PVP as adhesive; making pellet of 20 mesh; and encapsulating. The slow released veterinary medicine capsule has long medicine retaining time in the disease focus, high local medicine concentration, excellent bioadhesion and obvious medicine slow releasing characteristic.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, in particular to the preparation of veterinary drug cefoperazone and bletilla striata glue bioadhesive slow-release capsules by using cefoperazone and bletilla striata as raw materials and a preparation method thereof. Background technique [0002] As my country's animal husbandry is developing towards intensive and intensive direction, and the scale of animal husbandry continues to expand, ensuring the quality and safety of animal husbandry products has become an important issue that we need to solve. At present, the main problems of animal products in my country are: first, the threat of dangerous diseases; second, drug residues. Among them, drug residues in animal foods have endangered people's health. Therefore, the rational use of animal veterinary drugs and health products to control diseases and drug residues in the process of animal husbandry is an important problem that needs t...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/52A61K47/36A61K31/546A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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