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Applications of compound and cefoperazone pharmaceutical composition in preparing drugs used for treating periodontitis

A technology of cefoperazone and compound, which is applied in the preparation of organic compounds, drug combination, preparation of carboxylate, etc., can solve the problems such as the related reports of cefoperazone periodontitis, etc., and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2017-01-04
朱正直
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between cefoperazone and its pharmaceutical composition and the treatment of periodontitis

Method used

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  • Applications of compound and cefoperazone pharmaceutical composition in preparing drugs used for treating periodontitis
  • Applications of compound and cefoperazone pharmaceutical composition in preparing drugs used for treating periodontitis
  • Applications of compound and cefoperazone pharmaceutical composition in preparing drugs used for treating periodontitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0018] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0019] Separation method: (a) Grind the lotus lobata (2kg), extract with 85% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in ethyl acetate extract with D101 type macroporous resin to remove impurities, first elute 6 column volumes with 30% ethanol, then elute 12 column volumes with 85% ethanol, collect 85% eluate, conce...

Embodiment 2

[0023] Embodiment 2: pharmacological action

[0024] In this example, the periodontitis rat model was prepared by cutting and peeling the rat gums and feeding them with white sugar, and observed the anti-periodontitis effect of the drug on improving the redness, swelling, ulceration and atrophy of the gums of the animals.

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] 5-week-old SD rats with complete tooth and dentition, no caries and periodontal disease, half male and half male, weighing 200±20 g, were provided by Hubei Experimental Animal Research Center.

[0028] 1.2 Reagents and samples

[0029] Cefoperazone was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. White granulated sugar is made into 10% sugar water as drinking water, and conventional feed is soaked into soft feed with this sugar water when feeding. Koutai (compound ...

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Abstract

The invention relates to novel applications of cefoperazone, and more specifically relates to applications of a compound and a cefoperazone pharmaceutical composition in treating periodontitis The cefoperazone pharmaceutical composition contains cefoperazone and a natural product compound (I) with a novel structure. Independent application of cefoperazone, and independent application of the compound (I) both possess treatment effects on periodontitis, and cefoperazone and the compound (I) can be used for preparing drugs used for treating periodontitis. Curative effect is improved further via combination of cefoperazone with the compound (I), and the drugs used for treating periodontitis can be developed preferably. Compared with the prior art, the applications possess following advantages: substantive distinguishing features and significant progress are achieved.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of cefoperazone, in particular to the application of a natural compound and a pharmaceutical composition of cefoperazone in treating periodontitis. Background technique [0002] Cefoperazone is used for the treatment of various infections caused by sensitive enzyme-producing bacteria, such as the treatment of respiratory system, genitourinary system, biliary tract, gastrointestinal tract, chest and abdominal cavity, skin and soft tissue infections, and the treatment of infections caused by influenza bacillus and meningococcus Intracerebral infection also has a good curative effect. [0003] So far, there is no report on the correlation between cefoperazone and its pharmaceutical composition and the treatment of periodontitis. Contents of the invention [0004] The object of the present invention is to provide a kind of purposes of natural compound in the medicine of p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/235A61K31/546A61P1/02C07C69/78C07C67/48C07C67/56
CPCA61K31/235A61K31/546A61K36/29C07C69/78A61K2300/00
Inventor 朱正直
Owner 朱正直
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