Lactating sow feed containing fermentation raw materials and preparation method thereof

By using three-layer microcapsule coating technology, the problem of reduced activity of auxiliary feed in lactating sow feed under storage and acidic conditions has been solved, achieving stability of active ingredients and balanced nutritional supply, thereby improving sow milk production and piglet health.

CN121101085APending Publication Date: 2025-12-12ANHUI TECH-BANK FEED IND CO LTD

Patent Information

Application Number
CN202511506033.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-21
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

The auxiliary ingredients in existing lactating sow feed are prone to inactivation during storage, especially enzyme preparations and probiotics, whose activity decreases under acidic conditions, and the processing cost is high.

Method used

The three-layer microcapsule coating technology is adopted. The inner layer uses sodium alginate, the middle layer uses sodium carboxymethyl cellulose and chitosan oligosaccharide graft copolymer, and the outer layer uses chitosan and gelatin to encapsulate the auxiliary materials and form a stable microcapsule structure, protecting the enzyme preparation and probiotic agent from the effects of temperature and acidity.

Benefits of technology

It significantly improved the survival rate and enzyme activity retention rate of the feed additives in acidic gastric juice, reduced the amount of coating raw materials used, and improved the milk production of sows and the health status of piglets.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to the technical field of feed processing, and discloses a lactating sow feed containing fermentation raw materials and a preparation method of the lactating sow feed. A three-layer microcapsule coating auxiliary material is prepared by taking a vitamin premix, an amino acid compound, a compound enzyme preparation and a probiotic agent as core materials through three-layer coating; the basic raw materials comprise corn, wheat, bran, a fermentation raw material, a mineral premix and grease, auxiliary material coating and basic raw material treatment are carried out in parallel in double lines during preparation, and finally, mixing granulation is carried out; the grafted copolymer formed by the amidation reaction of the sodium carboxymethyl cellulose and the chitosan oligosaccharide can cooperate with the sodium alginate to prevent the damage under acidic conditions, and the survival rate of viable bacteria is kept at 85-87% after treatment is carried out for 2 hours under the acidic condition with the pH value of 2.0-3.0; compared with a traditional fermentation raw material coating scheme, the dosage of coating raw materials is reduced by 70% or above; meanwhile, the vitamin premix and the amino acid compound in the auxiliary material can reduce the diarrhea rate by 6% and increase the lactation yield of the sow by 7-18%.
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Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of feed processing, and particularly relates to a lactating sow feed containing fermented raw materials and a preparation method thereof, and especially relates to a technical scheme for improving the stability of active ingredients of the feed and the application effect of breeding by using the auxiliary material coated by three-layer microcapsules. BACKGROUND

[0002] During the lactation period, lactating sows need to meet the dual physiological needs of their own recovery and lactation. The nutritional balance, active ingredient utilization rate and health safety of the feed directly determine the lactation amount, milk quality, piglet survival rate and subsequent reproductive performance of the sow. At present, fermented raw materials have been widely used in improving the intestinal environment of sows and improving immunity due to the rich small molecule peptides, organic acids and natural active substances; and auxiliary materials such as complex enzyme preparations and probiotic agents can further promote the digestion and absorption of feed and regulate intestinal flora, which are key functional components of lactating sow feed.

[0003] However, the prior art has the following problems: The auxiliary material is prone to inactivation during long-term storage: the survival rate of probiotics is less than 50% and the loss rate of enzyme activity is more than 40% during the storage of complex enzyme preparations and probiotic agents due to the influence of temperature and oxygen.

[0004] Prone to inactivation under acidic conditions: when complex enzyme preparations and probiotic agents are directly added, they are easily destroyed by the gastric acid (pH 2.0-3.0) in the stomach of sows, the effective dose reaching the intestine is reduced, and it is difficult to play a role in promoting digestion and regulating flora.

[0005] In view of the above problems, the prior art mostly adopts the scheme of coating fermented raw materials, but the proportion of fermented raw materials is high (usually 20-30 parts), the coating cost is high and the processing difficulty is great, so there is an urgent need for a lactating sow feed to solve the above problems. SUMMARY

[0006] The present application aims to overcome the defects of low activity during long-term storage, inactivation under acidic conditions and high processing cost in the prior art, and provides a lactating sow feed containing three-layer microcapsule coated auxiliary material and a preparation method thereof. Through precise matching of a small amount of auxiliary material coating and basic raw materials, the active ingredients are long-acting and stable, the destruction by acidic conditions is actively prevented, and multiple functions of lactation promotion and nutritional balance are achieved.

[0007] According to the above idea, the first aspect of the present application provides a lactating sow feed containing fermented raw materials, which specifically comprises: 57.5-93 parts by mass of basic raw materials and 2-8 parts by mass of three-layer microcapsule coated auxiliary material; The base raw material is composed of the following components by mass: corn 40-52 parts, wheat 5-15 parts, bran 5-10 parts, fermentation raw material 5-10 parts, mineral premix 0.5-1 part, and oil and fat 2-5 parts; The fermentation raw material includes a mixture of fermented soybean meal, plant extract, and fermented algae.

[0008] The auxiliary material includes a mixture of vitamin premix, amino acid complex, complex enzyme preparation, and probiotic agent; The auxiliary material coated by the three-layer microcapsule has the auxiliary material, inner layer wall material, intermediate layer, and outer layer wall material from inside to outside; The inner layer wall material is sodium alginate for wrapping the auxiliary material; The intermediate layer is a grafted copolymer formed by the amidation reaction of carboxymethyl cellulose sodium and chitosan oligosaccharide for enhancing the coating stability in an acidic environment and reducing the loss of live bacteria of the auxiliary material; The outer layer wall material is a mixture of chitosan and gelatin for preventing particle breakage.

[0009] Preferably, the mass ratio of the vitamin premix, amino acid complex, complex enzyme preparation, and probiotic agent of the auxiliary material is 1:3:1:1.

[0010] Optionally, the amino acid complex includes one or more of arginine, tryptophan, and valine.

[0011] Optionally, the complex enzyme preparation contains any one of cellulase, amylase, and protease.

[0012] Optionally, the probiotic agent contains any one of Bacillus subtilis, Lactobacillus acidophilus, and Bacillus licheniformis.

[0013] Preferably, the mineral premix includes trace elements.

[0014] Optionally, the trace elements include any one or more of copper, iron, zinc, manganese, selenium, and iodine.

[0015] Optionally, the mass of copper is 5-25 mg / kg, the mass of iron is 30-200 mg / kg, the mass of zinc is 30-100 mg / kg, the mass of manganese is 10-70 mg / kg, the mass of selenium is 0.2-0.5 mg / kg, and the mass of iodine is 0.1-2 mg / kg.

[0016] Optionally, the vitamin premix includes vitamins.

[0017] Optionally, the vitamins include one or more of vitamin A, vitamin D3, and vitamin E.

[0018] Optionally, the mass of vitamin A is 1.3-12 KIU / kg, the mass of vitamin D3 is 1-45 KIU / kg, and the mass of vitamin E is ≥40 mg / kg.

[0019] Preferably, the mass ratio of the fermented soybean meal, the plant extract, and the fermented algae is 5:3:2.

[0020] Preferably, the fermented raw material comprises a mixture of fermented soybean meal, plant extract, and fermented algae.

[0021] Optionally, the fermented soybean meal comprises any one of whole soybean meal, soybean meal and peanut meal, and soybean meal and cottonseed protein.

[0022] Optionally, the plant extract comprises one or more than two of astragalus, motherwort, and licorice root.

[0023] Optionally, the fermented algae comprises one or more than one of spirulina, brown algae, and chlorella.

[0024] Preferably, the auxiliary material needs to be subjected to low-temperature vacuum drying treatment to control the water content to be ≤8% and is subjected to ultrafine grinding to have a particle size of 60-100 mesh.

[0025] Preferably, the fermented soybean meal has a crude protein content of ≥45%, the plant extract has an astragalus polysaccharide content of ≥10% and a motherwort flavone content of ≥8%, and the fermented algae has a crude fat content of ≥15%.

[0026] Preferably, the fermented raw material has a water content of ≤10%, a viable bacterial count of ≥10 9 CFU / g, an organic acid content of ≥2.5%, and a crude fiber content of ≤6%.

[0027] Preferably, the sodium alginate solution is used as an inner wall material to form a gel microsphere through ionic crosslinking with calcium chloride, and the pH stability of the gel microsphere can reduce the release rate of the core material in the stomach (pH 2.0-3.0) to avoid the destruction of the active ingredients by gastric acid.

[0028] Preferably, the sodium carboxymethyl cellulose and chitosan oligosaccharide graft copolymer can enhance the stability of the coated structure in an acidic environment and reduce the loss of viable bacteria in the auxiliary material in a gastric acid environment.

[0029] Preferably, the total particle size of the auxiliary material coated by the three-layer microcapsules is 0.8-1.5 mm, the thickness of the inner wall material is 30-60 μm, the thickness of the intermediate layer is 50-90 μm, the thickness of the outer wall material is 40-80 μm, and the embedding rate of the auxiliary material is ≥92%.

[0030] Optionally, the oil is any one of soybean oil, fish oil, and palm oil.

[0031] Preferably, the auxiliary material is mixed with the sodium alginate solution at a mass ratio of 1:2.

[0032] Preferably, the sodium carboxymethyl cellulose and chitooligosaccharide are mixed at a mass ratio of 10:1, the sodium carboxymethyl cellulose serves as a main skeleton and can provide good film-forming property and flexibility, and the chitooligosaccharide serves as a cross-linking enhancer and can be combined with the carboxyl group of the sodium carboxymethyl cellulose through hydrogen bonds to form a dense three-dimensional network structure.

[0033] In a second aspect of the present application, a preparation method of sow feed is provided, which specifically comprises the following steps: S1, auxiliary material preparation The vitamin premix, amino acid compound, complex enzyme preparation and probiotic agent are mixed at a mass ratio of 1:3:1:1, uniformly stirred in a sterile environment, and an auxiliary material is obtained; S2, auxiliary material pretreatment The auxiliary material is subjected to low-temperature vacuum drying, the water content is controlled to be less than or equal to 8%, and then the auxiliary material is subjected to ultrafine grinding to 60-100 meshes to obtain a pretreated auxiliary material.

[0034] S3, inner layer coating The pretreated auxiliary material is mixed with 2-3% sodium alginate solution at a mass ratio of 1:2, high-speed stirring is performed at a rotating speed of 1500 r / min for 15 min to form a mixed emulsion, the mixed emulsion is dropped into a 0.1 mol / L calcium chloride solution at a dropping speed of 0.8-1.2 mL / min, and the inner layer coated microspheres are formed after standing for 30 min; S4, intermediate layer coating The sodium carboxymethyl cellulose and chitooligosaccharide are dissolved in distilled water at a mass ratio of 10:1, a sodium carboxymethyl cellulose and chitooligosaccharide grafted copolymer solution is prepared by incubation at 50°C for 2 h under the condition of pH 9.0-10.0, the inner layer coated microspheres are put into the solution, constant temperature stirring is performed at 30°C for 40-60 min at a rotating speed of 200 r / min, and then the microspheres are taken out and washed once with deionized water, and then drained; S5, outer layer coating The chitosan and gelatin are dissolved in distilled water at a mass ratio of 1:2, a chitosan-gelatin mixed solution is prepared by adjusting the pH to 5.5 with 1% acetic acid after stirring and dissolving at 50°C, the microspheres coated with the intermediate layer are put into the mixed solution, constant temperature stirring is performed at 30°C for 60 min, and then the microspheres are taken out, washed with deionized water, and dried by air blowing at 40°C to obtain the auxiliary material coated with three-layer microcapsules; S6, fermentation raw material pretreatment The fermented soybean meal, plant extract and fermented algae are mixed at a mass ratio of 5:3:2, uniformly stirred, subjected to low-temperature vacuum drying, the water content is controlled to be less than or equal to 10%, and then the pretreated fermentation raw material is obtained by grinding to 80-120 meshes; S7, mixing and granulation The corn is crushed to 20-40 mesh, and then 40-52 parts of the crushed corn, 5-15 parts of wheat, 5-10 parts of bran, 5-10 parts of fermentation raw material, 0.5-1 part of mineral premix, 2-5 parts of oil and fat, and 2-8 parts of three-layer microcapsule coating auxiliary material are added, and the mixed material is stirred for 3 minutes and then sent into a granulator, and the temperature of the material is adjusted to 85 DEG C, and then the material is cooled to room temperature after granulation to obtain the lactating sow feed.

[0035] The beneficial effects of the present application are: 1. The three-layer microcapsule coating structure of the present application can effectively avoid the inactivation of the auxiliary material complex enzyme preparation by gastric acid and the inactivation of the probiotic agent by temperature and oxygen, and the survival rate in the acid simulated gastric juice with pH 2.0-3.0 can reach 85-87%, and the survival rate of live bacteria after 90 days of sealed storage at 25 DEG C is still ≥89%, and the enzyme activity retention rate is ≥90%.

[0036] 2. The three-layer coating is only applied to the auxiliary material accounting for 2-8 parts, and compared with the traditional coating scheme of 20-30 parts of fermentation raw material, the coating raw material consumption is reduced by more than 70%; at the same time, the vitamin premix and amino acid complex in the auxiliary material can realize balanced nutrition supply, and can make the lactation of sows increase by 7-18% and the diarrhea rate decrease by 6%. BRIEF DESCRIPTION OF DRAWINGS

[0037] Figure 1 is the flow chart of the present application for preparing feed. DETAILED DESCRIPTION

[0038] In order to make the technical means, creative features, purposes and effects of the present application easy to understand, the present application is further described below in combination with specific embodiments.

[0039] The present application comprises the following components by mass fraction: base raw material 57.5-93 parts and three-layer microcapsule coated auxiliary material 2-8 parts; The base raw material is composed of the following components by mass fraction: corn 40-52 parts, wheat 5-15 parts, bran 5-10 parts, fermentation raw material 5-10 parts, mineral premix 0.5-1 parts and oil and fat 2-5 parts; The fermentation raw material comprises a mixture of fermented soybean meal, plant extract and fermented algae.

[0040] The auxiliary material comprises a mixture of vitamin premix, amino acid complex, complex enzyme preparation and probiotic agent; The three-layer microcapsule coated auxiliary material comprises auxiliary material, inner layer wall material, intermediate layer and outer layer wall material from inside to outside; The inner layer wall material is sodium alginate for wrapping the auxiliary material; The intermediate layer is a grafted copolymer formed by amidation reaction of sodium carboxymethyl cellulose and chitosan oligosaccharide, which is used to enhance the coating stability in acidic environment and reduce the loss of live bacteria of the auxiliary material; The outer layer wall material is a mixture of chitosan and gelatin, which is used to prevent particle breakage.

[0041] Example 1 S1, Preparation of auxiliary material Mix 1 kg of vitamin premix, 3 kg of amino acid complex, 1 kg of complex enzyme preparation, and 1 kg of probiotic agent in a sterile environment. Stir for 15 minutes using a double helix mixer to obtain a uniform auxiliary material of 6 kg.

[0042] S2, Pretreatment of auxiliary material Place the auxiliary material in a vacuum drying oven and dry it at 35-40°C and a vacuum degree of -0.08~-0.06 MPa for 4 hours to control the moisture content to ≤8%. Then, use an ultrafine grinder to grind it to 60 mesh to obtain 5 kg of pretreated auxiliary material.

[0043] S3, inner layer coating Prepare a 2% sodium alginate solution. Mix 5 kg of pretreated auxiliary material with 10 kg of sodium alginate solution at a stirring speed of 1500 r / min for 15 minutes to form a uniform emulsion. Drop the emulsion into a 0.1 mol / L calcium chloride solution at a rate of 1.0 mL / min using a peristaltic pump. Let it stand for 30 minutes to allow the sodium alginate to crosslink with calcium ions and solidify, forming an inner layer coated microsphere. Drain the water.

[0044] S4, intermediate layer coating Dissolve 180 g of sodium carboxymethyl cellulose and 18 g of chitosan oligosaccharide in 10 L of distilled water. Adjust the pH to 9.5 with a 10% sodium hydroxide solution and incubate in a 50°C constant temperature water bath for 2 hours to prepare a sodium carboxymethyl cellulose-chitosan oligosaccharide grafted copolymer solution. Add the inner layer coated microspheres to the solution and stir at 30°C for 50 minutes. After removing the microspheres, rinse them once with deionized water and drain the surface moisture to obtain intermediate layer coated microspheres.

[0045] S5, outer layer coating Dissolve 100 g of chitosan and 200 g of gelatin in 10 L of distilled water. After dissolving at 50°C, adjust the pH to 5.5 with a 1% acetic acid solution to prepare a chitosan-gelatin mixed solution. Add the intermediate layer coated microspheres to the solution and stir at 30°C for 60 minutes. After removing the microspheres, rinse them twice with deionized water and dry them in a 40°C air-drying oven until the moisture content is ≤8% to obtain 7 kg of three-layer microcapsule coated auxiliary material.

[0046] S6, pretreatment of fermentation raw material 7.5 kg of fermented soybean meal, 4.5 kg of plant extract, 3 kg of fermented algae were mixed in a mass ratio of 5:3:2, and stirred for 15 min with a double helix mixer; the mixture was placed in a vacuum drying oven, dried at 40-45 °C, vacuum degree -0.07 to -0.05 MPa for 3 h, and the moisture content was controlled to be ≤10%; then it was crushed to 100 mesh with a crusher, and 13 kg of pretreated fermentation raw material was obtained.

[0047] S7, mixing and granulation The corn was crushed to 30 mesh, and 40 parts of crushed corn, 5 parts of wheat, 5 parts of bran, 5 parts of fermentation raw material, 0.5 parts of mineral premix, 2 parts of palm oil, and 2 parts of three-layer microcapsule coating auxiliary material were added. After stirring for 3 min, the mixed material was fed into a granulator, and the conditioning temperature was 85 °C. After granulation, it was cooled to room temperature to obtain a lactating sow feed.

[0048] Example 2 The rest are the same as Example 1, except that: 46 parts of corn, 10 parts of wheat, 7 parts of bran, 7 parts of fermentation raw material, 3 parts of palm oil, 0.7 parts of mineral premix, and 5 parts of three-layer microcapsule coating auxiliary material.

[0049] Example 3 The rest are the same as Example 1, except that: 52 parts of corn, 15 parts of wheat, 10 parts of bran, 10 parts of fermentation raw material, 5 parts of palm oil, 1 part of mineral premix, and 8 parts of three-layer microcapsule coating auxiliary material.

[0050] Comparative Example 1 The rest are the same as Example 1, except that: It does not contain sodium carboxymethyl cellulose-chitosan oligosaccharide intermediate layer coating.

[0051] Comparative Example 2 The rest are the same as Example 1, except that: It does not contain chitosan-gelatin outer layer coating.

[0052] Comparative Example 3 The rest are the same as Example 1, except that: It does not contain sodium alginate inner layer coating, sodium carboxymethyl cellulose-chitosan oligosaccharide intermediate layer coating, and chitosan-gelatin outer layer coating.

[0053] Table 1 Example and Comparative Example Data

[0054] The application improves the storage stability and breeding application effect of the feed through the three-layer synergistic coating structure of the inner layer sodium alginate, the middle layer sodium carboxymethyl cellulose-chitosan oligosaccharide and the outer layer chitosan-gelatin. Experimental data show that examples 1-3 using the complete three-layer coating process are better than comparative examples 1-3 with incomplete coating structure in key indicators: In terms of long-term storage and acid resistance, the survival rate of live bacteria of examples 1-3 treated with pH 2.0-3.0 acid simulated gastric juice for 2h is as high as 85%-87%, and the survival rate of live bacteria remains 89%-91% after 90 days of sealed storage at 25℃, while comparative example 1 lacking the middle layer, comparative example 2 lacking the outer layer and comparative example 3 without coating, all have incomplete coating structure, resulting in a significant decrease in storage stability, the survival rate of live bacteria treated with acid simulated gastric juice for 2h is 40%-62%, which verifies the synergistic effect of three-layer coating on live bacteria protection and acid destruction.

[0055] In terms of breeding effect, the average daily milk yield of sows of examples 1-3 is 5.9-6.5 kg, and the diarrhea rate of piglets is as low as 2.0%-3.0%, which is significantly better than 4.9-5.5 kg of comparative examples 1, 2 and 3. The difference is due to the three-layer coating which can accurately control the intestinal release efficiency of active ingredients (probiotics, fermentation products), and the lack of coating structure will lead to a decrease in the absorption rate of effective components, thereby affecting the milk performance and piglet health. In breeding application, the diarrhea rate of piglets of examples 1-3 is as low as 2.0%-3.0%, which is significantly reduced compared with 8.0% of comparative example 1, which verifies that the application can effectively improve the health status of piglets by adjusting the microcapsule coating process and raw material ratio.

[0056] From the technical common sense, the application can be realized by other embodiments without departing from the spirit or essential characteristics thereof. Therefore, the above disclosed embodiments are only examples and are not the only ones. All changes within the scope of the application or within the scope equivalent to the application are included in the application.

Claims

1. A feed for lactating sows containing fermented raw materials, characterized in that, The components include the following parts by weight: 57.5-93 parts of basic raw material and 2-8 parts of excipients for three-layer microcapsule coating; The basic raw materials consist of the following components in parts by weight: 40-52 parts corn, 5-15 parts wheat, 5-10 parts wheat bran, 5-10 parts fermentation raw materials, 0.5-1 parts mineral premix, and 2-5 parts oil. The fermentation raw materials include a mixture of fermented soybean meal, plant extracts and fermented algae; The auxiliary materials include a mixture of vitamin premix, amino acid complex, compound enzyme preparation and probiotic agent; The auxiliary material encapsulated in three layers of microcapsules consists of, from the inside out, the auxiliary material, the inner wall material, the middle layer, and the outer wall material. The inner wall material is sodium alginate used to wrap the auxiliary materials; The intermediate layer is a graft copolymer formed by the amidation reaction of sodium carboxymethyl cellulose and chitosan oligosaccharide to enhance coating stability under acidic conditions and reduce the loss of live bacteria in the auxiliary material; The outer wall material is a mixture of chitosan and gelatin used to prevent particle breakage.

2. The lactating sow feed containing fermented raw materials according to claim 1, characterized in that, The fermented soybean meal has a crude protein content of ≥45%, the plant extract contains ≥10% astragalus polysaccharide and ≥8% motherwort flavonoids, and the fermented algae has a crude fat content of ≥15%.

3. The lactating sow feed containing fermented raw materials according to claim 1, characterized in that, The moisture content of the fermentation raw materials is ≤10%, and the viable count is ≥10. 9 CFU / g, organic acid content ≥2.5%, and crude fiber content ≤6%.

4. The lactating sow feed containing fermented raw materials according to claim 1, characterized in that, The total particle size of the three-layer microcapsule coating auxiliary material is 0.8-1.5 mm, wherein the thickness of the inner wall material is 30-60 μm, the thickness of the middle layer is 50-90 μm, the thickness of the outer wall material is 40-80 μm, and the encapsulation rate of the auxiliary material is ≥92%.

5. The lactating sow feed containing fermented raw materials according to claim 1, characterized in that, The mineral premix includes trace elements; The trace elements include any one or more of copper, iron, zinc, manganese, selenium, and iodine; The mass of copper is 5~25 mg / kg, the mass of iron is 30~200 mg / kg, the mass of zinc is 30~100 mg / kg, the mass of manganese is 10~70 mg / kg, the mass of selenium is 0.2~0.5 mg / kg, and the mass of iodine is 0.1~2 mg / kg.

6. The lactating sow feed containing fermented raw materials according to claim 1, characterized in that, The oil is any one of soybean oil, fish oil, and palm oil.

7. The lactating sow feed containing fermented raw materials according to claim 1, characterized in that, The vitamin premix includes vitamins; The vitamins include one or more of vitamin A, vitamin D3, and vitamin E; The mass of vitamin A is 1.3~12 KIU / kg, the mass of vitamin D3 is 1~45 KIU / kg, and the mass of vitamin E is ≥40 mg / kg.

8. The lactating sow feed containing fermented raw materials according to claim 1, characterized in that, The amino acid complex includes one or more of arginine, tryptophan, and valine.

9. A method for preparing a feed according to any one of claims 1 to 8, characterized in that, Includes the following steps: S1, Preparation of auxiliary materials Vitamin premix, amino acid complex, compound enzyme preparation and probiotic agent are mixed in a mass ratio of 1:3:1:1 and stirred evenly under sterile conditions to obtain auxiliary material; S2, Auxiliary material pretreatment The auxiliary materials are subjected to low-temperature vacuum drying to control the moisture content to ≤8%, and then ultra-finely pulverized to 60-100 mesh to obtain the pretreated auxiliary materials. S3, Inner Coating The pretreated auxiliary material was mixed with 2-3% sodium alginate solution at a mass ratio of 1:2 and stirred at 1500 r / min for 15 min to form a mixed emulsion. The mixed emulsion was then dropped into 0.1 mol / L calcium chloride solution at a dropping rate of 0.8-1.2 mL / min and allowed to stand for 30 min to form inner-coated microspheres. S4, Intermediate Layer Coating Sodium carboxymethyl cellulose and chitosan oligosaccharide were dissolved in distilled water at a mass ratio of 10:1 and kept at pH 9.0-10.0 and 50℃ for 2 hours to obtain a grafted copolymer solution of sodium carboxymethyl cellulose and chitosan oligosaccharide. The inner-coated microspheres were added to the solution and stirred at 30℃ for 40-60 minutes at a speed of 200 r / min. After stirring, the microspheres were rinsed once with deionized water and drained. S5, outer coating Chitosan and gelatin were dissolved in distilled water at a mass ratio of 1:

2. After stirring at 50°C, the pH was adjusted to 5.5 with 1% acetic acid to obtain a chitosan-gelatin mixed solution. Microspheres coated with the intermediate layer were added to the mixed solution and stirred at 30°C for 60 min. After being removed, they were rinsed with deionized water and dried in a forced-air dryer at 40°C to obtain an auxiliary material coated with three layers of microcapsules. S6. Fermentation raw material pretreatment Fermented soybean meal, plant extracts and fermented algae were mixed in a mass ratio of 5:3:2, stirred evenly and then dried under low temperature vacuum to control the moisture content to ≤10%. The mixture was then pulverized to 80-120 mesh to obtain the pretreated fermented raw material. S7, Mixing and Granulation Crush corn to 20-40 mesh, add 40-52 parts crushed corn, 5-15 parts wheat, 5-10 parts bran, 5-10 parts fermentation raw materials, 0.5-1 parts mineral premix, 2-5 parts oil, and 2-8 parts three-layer microcapsule coating auxiliary materials. Stir for 3 minutes and then feed the mixed material into a granulator. The conditioning temperature is 85℃. After granulation, cool to room temperature to obtain lactating sow feed.

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