Mesoporous silica nano-preparation and its preparation method and use

A technology of mesoporous silica and nano-preparation, applied in the field of medicine, can solve the problems such as the inability of nanoparticles to achieve drug loading and encapsulation effect, and achieve the effect of maintaining drug activity, broad application prospects and uniform distribution.
CN103990130AInactive Publication Date: 2014-08-20SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2014-08-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a mesoporous silica nano-preparation. The mesoporous silica nano-preparation comprises docetaxel or 8-hydroxyquinoline, mesoporous silica nanoparticles, and a lipid double-molecule layer. The mesoporous silica nanoparticles carry docetaxel or 8-hydroxyquinoline. The surfaces of the mesoporous silica nanoparticles carrying docetaxel or 8-hydroxyquinoline are coated with the lipid double-molecule layer. The invention also discloses a preparation method and a use of the mesoporous silica nano-preparation. The mesoporous silica nano-preparation carrying docetaxel or 8-hydroxyquinoline can substantially improve antitumor activity of a drug, can effectively reduce tumor recurrence and nonspecific toxicity and has a very wide application prospect.
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Description

Technical field

[0001] The invention relates to the technical field of medicine, in particular to a mesoporous silica nano-preparation loaded with 8-hydroxyquinoline (8-HQ) or docetaxel (DTX), and a preparation method and application of the nano-preparation. Background technique

[0002] At present, a large number of facts have proved that breast tumors are caused by tumor stem cells, and the cure of breast tumors requires the complete elimination of tumor stem cells. Because of the resistance of cancer stem cells to conventional chemotherapeutics and resistance to radiotherapy, as well as the proliferation of residual cancer stem cells after treatment, cancer stem cells play a key role in tumor treatment and recurrence.

[0003] 8-Hydroxyquinoline is a compound that selectively targets cancer stem cells or initiating cells. Combined with conventional chemotherapeutics, it can significantly improve the therapeutic effect of tumors and reduce tumor recurrence. Docetaxel is a semi-s...

Claims

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