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Mesoporous silica nano-preparation and its preparation method and use

A technology of mesoporous silica and nano-preparation, applied in the field of medicine, can solve the problems such as the inability of nanoparticles to achieve drug loading and encapsulation effect, and achieve the effect of maintaining drug activity, broad application prospects and uniform distribution.

Inactive Publication Date: 2014-08-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the physical properties of 8-hydroxyquinoline, the preparation method of conventional nanoparticles cannot achieve the ideal drug loading and encapsulation effect. Therefore, there have been no reports of 8-hydroxyquinoline nano-preparation at home and abroad.

Method used

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  • Mesoporous silica nano-preparation and its preparation method and use
  • Mesoporous silica nano-preparation and its preparation method and use
  • Mesoporous silica nano-preparation and its preparation method and use

Examples

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preparation example Construction

[0039] The preparation method of the mesoporous silica nano preparation of the present invention includes the following steps:

[0040] 1. Preparation of Mesoporous Silica Nanoparticles (MSN)

[0041] In a 500mL two-necked round bottom flask equipped with a mechanical stirrer and a thermometer, a certain amount of cetyltrimethylammonium bromide (CTAB) was dissolved in ultrapure water, and a certain amount of 2.0M NaOH solution was added. After homogenization, the mixed solution was heated to a certain temperature for 30 minutes to obtain a clear liquid. A certain amount of tetraethylorthosilicate (TEOS) was injected into the mixed solution and stirred at a certain speed. After 3 minutes, a white precipitate was visible. Maintain the reaction temperature at a certain temperature for 2 hours. The mixed solution was cooled to room temperature, the solid product was separated by centrifugation (3500rpm, 15min), the supernatant was removed, the precipitate was washed three times with u...

Embodiment 1

[0102] Example 1 Preparation of mesoporous silica lipid targeted nanoparticles loaded with 8-hydroxyquinoline or docetaxel

[0103] 1. Preparation of Mesoporous Silica Nanoparticles (MSN)

[0104] In a 500mL two-necked round bottom flask equipped with a mechanical stirrer and a thermometer, dissolve 0.75g of CTAB in 480mL of ultrapure water, add 3.5mL of 2.0M sodium hydroxide aqueous solution, mix well, and raise the mixed solution to 80℃ Maintained for 30min, a clear liquid was obtained. 4.67g TEOS was continuously and rapidly injected into the mixed solution, stirred at 550rpm, white precipitate was visible after 3min, and the reaction temperature was maintained at 80°C for 2h. The solid product was separated by centrifugation at room temperature (3500 rpm, 15 min), the supernatant was removed, and the precipitate was washed three times with ultrapure water and ethanol, and dried in vacuum for 12 hours. After 12h, calcine in a muffle furnace at 550°C for 5h to remove the surfac...

Embodiment 2

[0118] Example 2 Preparation of mesoporous silica lipid-targeted nanoparticles loaded with 8-hydroxyquinoline or docetaxel

[0119] 1. Preparation of Mesoporous Silica Nanoparticles (MSN)

[0120] In a 500mL two-necked round bottom flask equipped with a mechanical stirrer and a thermometer, dissolve 0.25g of CTAB in 120mL of ultrapure water, add 1.5mL of 2.0M sodium hydroxide aqueous solution, mix well, and raise the mixed solution to 60℃ Maintained for 45min, a clear liquid was obtained. 1.25 g of TEOS was continuously and rapidly injected into the mixed solution, stirred at 200 rpm, white precipitates were visible after 3 minutes, and the reaction temperature was maintained at 60°C for 2 hours. The solid product was separated by centrifugation (3500 rpm, 15min) at room temperature, the supernatant was removed, and the precipitate was washed three times with ultrapure water and ethanol, and dried in vacuum for 12 hours. After 12h, calcine in a muffle furnace at 550°C for 5h to r...

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Abstract

The invention discloses a mesoporous silica nano-preparation. The mesoporous silica nano-preparation comprises docetaxel or 8-hydroxyquinoline, mesoporous silica nanoparticles, and a lipid double-molecule layer. The mesoporous silica nanoparticles carry docetaxel or 8-hydroxyquinoline. The surfaces of the mesoporous silica nanoparticles carrying docetaxel or 8-hydroxyquinoline are coated with the lipid double-molecule layer. The invention also discloses a preparation method and a use of the mesoporous silica nano-preparation. The mesoporous silica nano-preparation carrying docetaxel or 8-hydroxyquinoline can substantially improve antitumor activity of a drug, can effectively reduce tumor recurrence and nonspecific toxicity and has a very wide application prospect.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a mesoporous silica nano-preparation loaded with 8-hydroxyquinoline (8-HQ) or docetaxel (DTX), and a preparation method and application of the nano-preparation. Background technique [0002] At present, a large number of facts have proved that breast tumors are caused by tumor stem cells, and the cure of breast tumors requires the complete elimination of tumor stem cells. Because of the resistance of cancer stem cells to conventional chemotherapeutics and resistance to radiotherapy, as well as the proliferation of residual cancer stem cells after treatment, cancer stem cells play a key role in tumor treatment and recurrence. [0003] 8-Hydroxyquinoline is a compound that selectively targets cancer stem cells or initiating cells. Combined with conventional chemotherapeutics, it can significantly improve the therapeutic effect of tumors and reduce tumor recurrence. Docetaxel is a semi-s...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K9/16A61K31/47A61K31/337B82Y5/00B82Y40/00A61P35/00
Inventor 钟延强何为王冬张翮鲁莹黄景彬王新霞张国庆陈琰俞媛邹豪刘俊杰孙治国陶春贾婷婷吴珊向婧洁
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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