8 results about "Tumour targeting" patented technology

The invention belongs to the technical field of biology, and particularly relates to a composition for tumor targeted therapy, hydrogel and a preparation method and application thereof. The tumor targeted therapy composition provided by the invention comprises the aging tumor cells and the celecoxib, the immune activation function of the aging tumor cells is that STCs can effectively activate the maturation of dendritic cells and the immune function of T cells and NK cells, SASP of the STCs is regulated through the celecoxib, especially generation of prostaglandin E2 is inhibited, and the tumor targeted therapy effect is improved. And the combined use further enhances the anti-tumor immune effect.

A unique near-infrared (NIR) fluorescence imaging probe, ICG-p28, composed of the clinically nontoxic tumor-targeting peptide p28 and the FDA-approved NIR dye indocyanine green (ICG) have been analyzed for in vivo kinetics and optimized for clinical practice. Intraoperative imaging with ICG-p28 was used to identify small (≤1 mm) lymph nodes (LNs) containing cancer cells. Image-guided surgery with ICG-p28 showed an over 6.6x103-fold reduction in residual normalized tumor DNA at the margin site relative to control approaches, resulting in an improved tumor recurrence rate (92% specificity) in multiple animal models.

The invention provides a nano preparation for preparing a medicine for inhibiting prostatic cancer and a preparation method of the nano preparation, and relates to the technical field of nano medicinal preparations. The nano preparation comprises the following components in parts by mass: traditional Chinese medicine components and a nano carrier, the traditional Chinese medicine component comprises 15-45 parts of a Chinese yam extract, 5-15 parts of a madder extract, 8-20 parts of cuttlebone superfine powder, 10-25 parts of dragon bone superfine powder and 10-25 parts of oyster superfine powder; the nano-carrier comprises 5-20 parts of phospholipid, 2-10 parts of cholesterol, 1-5 parts of fatty acid, 3-15 parts of polyethylene glycol and 1-5 parts of a surfactant. The average particle size of the nano preparation is 80-150 nm, the polydispersity index PDI is smaller than or equal to 0.30, and the encapsulation efficiency is larger than or equal to 75%. According to the invention, active ingredients of traditional Chinese medicines are combined with a nanotechnology, so that the bioavailability and the tumor targeting property are remarkably improved, the pH-responsive release characteristic is achieved, a remarkable inhibition effect on various prostate cancer cell lines is shown, tumor growth can be effectively inhibited, metastasis can be reduced, and a good application prospect is achieved.

The present invention discloses a stem cell membrane nanocarrier for tumor-targeted magnetic diagnosis and chemotherapy and a preparation method thereof. The stem cell membrane nanocarrier is a nanocarrier formed by stem cell membrane-coated magnetic nanoparticle clusters and chemotherapy drugs. The magnetic nanoparticle clusters are obtained using an alternating magnetic field and temperature control. The magnetic nanoparticle clusters and chemotherapy drugs are jointly loaded into the stem cell membrane with the help of a static magnetic field or an alternating magnetic field. The prepared stem cell membrane nanocarrier has outstanding advantages such as large loading capacity, synergy of magnetic therapy and chemotherapy, and integrated diagnosis and treatment, and has great clinical potential for targeted magnetic diagnosis and chemotherapy.

1. The name of this design product: Radioactive seed protection implanter (snap-on type). 2. Purpose of this product design: This product design is used to connect with the corresponding radioactive seed implantation puncture needle with a card-fit interface to implant the radioactive seeds into the targeted tumor location, while providing radiation protection for the operator and other surrounding people. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

A conjugate compound comprises: TTA-X1-MNP-X2-TpA, wherein: TTA is a tumour targeting agent; MNP is a metal nanoparticle; TpA is a therapeutic agent; and X1 and X2 are the same or different, and are each independently selected from a non-covalent linker or a covalent linker. Methods for making the conjugate compound is provided. Methods and uses of the conjugate compound and a composition thereof for treating cancer.

A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy / s). Multiplexed transducers detect US and iRAI signals allowing for anatomical / functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.