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Bionic nano-carrier and application thereof in preparation of brain glioma treatment drugs

A technology of bionic nanometer and brain glioma, which is applied in the field of medicine

Pending Publication Date: 2021-04-30
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no report on the use of bionic nanocarriers hybridized with immune cell membranes and glioma cell membranes for the treatment of gliomas. According to the pathological characteristics and treatment needs of gliomas, the use of immune cells to pass through the blood-brain barrier, long-term Biomimetic nanocarriers designed based on the characteristics of the circulation and the homologous targeting properties of glioma cells can be used as an ideal drug delivery system for the treatment of glioma

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  • Bionic nano-carrier and application thereof in preparation of brain glioma treatment drugs
  • Bionic nano-carrier and application thereof in preparation of brain glioma treatment drugs
  • Bionic nano-carrier and application thereof in preparation of brain glioma treatment drugs

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Embodiment 1

[0052] The preparation method of biomimetic nano-carrier, comprises the following steps:

[0053] (1) According to the prescription amount, put soybean lecithin: DSPE-PEG2000: cholesterol: chemotherapeutic drug PTX mass ratio of 12:5:4:1 into an eggplant-shaped bottle, add an appropriate amount of chloroform to dissolve, and reduce pressure at 40°C The organic solvent was completely removed by rotary evaporation. After forming a uniform film on the wall of the bottle, add an appropriate amount of PBS preheated to the same temperature in a water bath at 40°C for shaking and hydration, and place the resulting suspension under the probe for ultrasonication to obtain the product. Ultrasound specifically means that the power is 300W, the total time is 3 minutes, the mode is super 3s, stop 2s, ice bath ultrasound.

[0054] (2) Human malignant glioma U87 cells and macrophages / monocytes in good growth state were digested separately, washed three times with PBS, the medium, serum, try...

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Abstract

The invention discloses a bionic nano-carrier and an application thereof in preparation of brain glioma treatment medicines, and belongs to the technical field of medicines. The bionic nano-carrier comprises a long-circulating liposome and a hybrid cell membrane; the long-circulating liposome serves as an inner core, the hybrid cell membrane serves as a shell, and the long-circulating liposome is coated with the hybrid cell membrane; and the hybrid cell membrane is formed by mixing an immune cell membrane and a tumor cell membrane. According to the nano-carrier disclosed by the invention, the long-circulating liposome is taken as a core, the core is coated with a hybrid cell membrane of immune cells and tumor cells, the nano-carrier moves and passes through a blood-brain barrier through the interaction of surface protein of the immune cells and receptors on brain endothelial cells, and meanwhile, the enhanced tumor targeting capability is realized through homologous targeting and homing effects, targeted treatment of brain glioma is achieved, and the chemotherapy effect is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a bionic nano-carrier and its application in the preparation of glioma treatment medicine. Background technique [0002] Malignant glioma is a primary tumor of the brain, which is mainly caused by the canceration of glial cells such as astrocytes or oligodendrocytes in the brain and spinal cord. In adults, glioblastoma accounts for more than half of all gliomas and is the most common malignant primary brain tumor. The treatment of glioma currently mainly includes surgery-based chemotherapy, radiotherapy, and targeted therapy. Due to the extensive infiltration of glioma growth and the high complexity of the nervous system, surgical treatment has the characteristics of incomplete resection and high recurrence rate, and postoperative adjuvant treatment is usually required. However, due to the existence of the blood-brain barrier, the use of chemotherapy drugs in the t...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/46A61K31/337A61P35/00A61P25/00C12N5/078C12N5/09
CPCA61K9/5068A61K31/337A61P35/00A61P25/00C12N5/0693C12N5/0634C12N2509/00C12N2509/10
Inventor 孙春萌周沐野纳西鲁涂家生
Owner CHINA PHARM UNIV
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