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Anthracene nucleus medicament nano-preparation, preparation method and application thereof

A nano-preparation and anthracycline technology, applied in the field of nano-preparation and its preparation, can solve the problems of high preparation conditions, expensive preparation equipment, QCQA is difficult to control, etc., to reduce costs, enhance anti-tumor activity, easy The effect obtained

Inactive Publication Date: 2008-09-24
NANJING UNIV
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Problems solved by technology

[0004] However, the traditional nano-preparation has the disadvantages of complicated preparation process, high requirements for preparation conditions, and relatively expensive preparation equipment, which leads to high production costs.
In addition, traditional nano-preparations still have disadvantages such as difficult QCQA control, low encapsulation efficiency, and low bioavailability.

Method used

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  • Anthracene nucleus medicament nano-preparation, preparation method and application thereof

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Embodiment Construction

[0026] According to the present invention, it is related to the effective compounding of anthracyclines and nucleic acids and then compounding with cationic compounds. In the specific implementation process, the cationic compounds we mainly investigate mainly include chitosan, polyethyleneimine (polyethyleneimine, PEI), polylysine amino acid (poly-L-lysine PLL), polyhistidine, polyarginine, polydimethylaminoethylmethacrylate (poly(2-(dimethylamino)ethylmethacrylate), pDMAEMA), and cationic Gelatin; the tested nucleic acids include deoxyribonucleic acid (DNA) and ribonucleic acid (RNA); the tested anthracyclines mainly include daunorubicin (daunorubicin, daunorubicin, daunomycin, DNR), doxorubicin (doxorubicin) , DOX, doxorubicin, adriamycin, ADM), epirubicin (epirubicin, EPI) and idarubicin (idarubicin, demethoxydaunorubicin, demethoxydaunorubicin, IDA) and synthetic mitoxantrone (mitoxatrone). The specific combination is epirubicin-DNA-cationized gelatin, daunubicin-DNA-chit...

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Abstract

The invention belongs to the biomedicine technology field, in particular relates to a new nano-preparation of anthracene-ring medicine, such as adriamycin, etc. and a preparation method thereof. The preparation is composed of anthracene-ring medicine such as adriamycin, nucleic acid, and cationic compound. The specific preparation process is that the anthracene-ring medicine is compounded with the nucleic acid firstly, and then is compounded with the cationic compound to form nano-granule. The preparation reduces the physiological toxicity of anthracene-ring medicine without reducing the anti-cancer activity, has tumor targeting characteristic and can be prepared into tumor-treating medicine.

Description

1. Technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a new nano preparation of anthracyclines such as doxorubicin and a preparation method thereof. 2. Background technology [0002] Anthracyclines such as doxorubicin are the most commonly used antineoplastic drugs in clinical practice. Its mechanism of action is mainly that the anthracycline planar structure of its molecule is inserted into the double-stranded structure of DNA molecule, which affects the function of DNA, inhibits DNA replication and RNA transcription, thereby inhibiting tumor proliferation, and is a non-specific drug for cell cycle. Its characteristics mainly include broad anti-cancer spectrum and high chemotherapy index. However, in addition to toxic and side effects such as bone marrow suppression, nausea, vomiting, stomatitis, hair loss, high fever, bleeding symptoms, phlebitis and skin pigmentation, there is also dose-dependent cardiotoxicit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/30A61K47/36A61K31/704A61P35/00A61K47/69
Inventor 张峻峰董磊夏苏华陈江宁
Owner NANJING UNIV
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