Molybdenum oxide nanosheets modified by Pluronic and its preparation method and application
A technology of pluronic and molybdenum oxide, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problem of reducing blood circulation time and EPR effect, reducing tumor treatment effect, nanometer The reduction of material enrichment and other issues can avoid long-term in vivo toxicity, strong light-to-heat conversion effect, and good biological safety.
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 In a typical embodiment of the present invention, the preparation method of the MoOx nanosheet of described Pluronic modification is provided, comprises the steps:
 Add Pluronic to the organic solvent dispersion of MoOx nanosheets for ultrasonic treatment, remove the organic solvent after ultrasonic treatment, then add water, continue ultrasonic treatment to obtain the aqueous dispersion of Pluronic@MoOx, and finally perform centrifugation to remove untreated particles. Reaction of Pluronic to obtain Pluronic-modified MoOx nanosheets.
 In a preferred embodiment of the present invention, a method for preparing MoOx nanosheets is provided, which includes: firstly synthesizing hydrophobic monolayer MoOx nanosheets with large particle size by a one-pot hydrothermal method, and then ultrasonically transforming them Broken into nano fragments to obtain MoOx nanosheets with the desired small particle size.
 The MoOx nanosheets prepared by the one-pot hyd...
 Synthesis of Molybdenum Oxide Nanosheets Modified by Pluronic
 (1) Synthesis of MoOx nanosheets: Accurately weigh 1.2359 g (1 mmol) of ammonium molybdate, dissolve it in 13 ml of deionized water, and then add 1.2 ml of 1 mol / L hydrochloric acid solution. Another 0.8 g of oleylamine was dissolved in 4 ml of cyclohexane, and under the action of magnetic stirring, the cyclohexane solution of oleylamine was slowly added to the ammonium molybdate solution, and stirred vigorously overnight to form a white emulsion. The white emulsion was transferred to a 25ml polytetrafluoroethylene-lined reactor and reacted at 180°C for 12h. Naturally cool to room temperature after the reaction, add 20ml cyclohexane to extract the MoOx nanosheets, then add 40ml of absolute ethanol to precipitate the MoOx nanosheets, remove the supernatant, and repeatedly remove impurities to obtain dark blue MoOx nanosheets and remove them. Disperse in dichloromethane for later use. The results of ...
 Preparation of DOX-loaded F127-modified MoOx nanosheets (MoOx@F127 / DOX)
Disperse or dissolve appropriate amount of MoOx, DOX and F127 in dichloromethane-ethanol (5:1, V / V) to prepare 3mg / ml MoOx dispersion, 3mg / ml DOX and 6mg / ml F127 solution. Mix 1ml of MoOx dispersion and 1ml of DOX solution, add 3ml of dichloromethane-ethanol solution and stir in the dark for 12h, then add 1ml of F127 solution and continue to stir for 12h, the probe is sonicated for a few minutes, and the organic solvent is removed by rotary evaporation, and then Add water and ultrasonically disperse, and centrifuge to remove unencapsulated DOX. With the same concentration of MoOx@F127 solution as a blank control, the absorbance value at 481nm was measured by UV-visible spectrophotometry and the drug loading rate was calculated (DLE (%)=(W LoadedDOX / W MoOx )×100%), the results showed that the drug loading rate was 46.9%.
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