Nanothermal seed material used for microwave tumour targeted thermal therapy

Abstract

The invention discloses a nanothermal seed material used for microwave tumour targeted thermal therapy. The nanothermal seed material used for the microwave tumour targeted thermal therapy is composed of the following components in percentage by weight: 40-75% of tin and manganese doped barium ferrite, 5-15% of magnesium oxide, 5-10% of titanium oxide and the balance of silicon oxide. The invention also discloses a preparation method of the nanothermal seed material. The preparation method of the nanothermal seed material comprises the following steps: firstly preparing tin and manganese doped barium ferrite nano powder, respectively weighing tin and manganese doped barium ferrite nano powder, magnesium oxide powder, titanium oxide powder and silicon oxide powder in percentage by weight according to a formula, fully dispersing by carrying out high-energy ball milling, then putting the fully dispersed powder into a graphite grinding tool, sintering in a hot pressing sintering furnace, mechanically pulverizing a composite material obtained after sintering, and refining to obtain nanoscale powder by utilizing high-energy ball milling. The nanothermal seed material has the characteristics of strong microwave heat effect, good biocompatibility and easiness for surface modification in a microwave frequency band used for tumour thermal therapy, and can be applied to microwave tumour targeted thermal therapy.

Description

technical field [0001] The invention relates to a nano thermal seed material used for tumor targeting hyperthermia, in particular to a tin-manganese-doped barium ferrite nano-powder, magnesium oxide powder, titanium oxide powder, and silicon oxide powder after heating A nano thermal seed material obtained by pressure sintering and ball milling refinement process and its preparation method. The invention belongs to the field of biomedical material science. Background technique [0002] With the increasing incidence and mortality of cancer year by year, the research on the diagnosis and treatment of tumor diseases has attracted more and more attention. In the treatment of tumors, the biggest difficulty is to ensure that tumor cells are killed without causing damage to normal cells or tissues. Microwave targeted hyperthermia uses microwave heat seed materials to heat tumor cells in the tumor area using the microwave heat effect of heat seed materials. To 43-47 ℃, and lead to ...

AI Technical Summary

Problems solved by technology

The key technical issue of targeted positioning microwave hyperthermia is the microwave heat seed material. The performance, heat production efficiency and temperature control of the heat seed material affect the application of microwave targeted hyperthermia. Although many material systems and tissue temperature measurement techniques have been reported It is used for targeted microwave tumor hyperthermia, but there are problems such as inaccurate positioning, low heat generation efficiency, unstable performance, and high price.