15 results about "Microwave hyperthermia" patented technology

The invention discloses a near-field focusing microwave thermal therapy device and method based on a Huygens metasurface. The device comprises a feed source antenna, a Huygens metasurface array and a biological tissue model. The feed source antenna is a 5.8 GHz double-ridge horn antenna and is used for transmitting x-polarized electromagnetic waves; the Huygens metasurface array is formed by periodically arranging double-layer through-hole-free Huygens units, anti-symmetric E-shaped metal patterns are symmetrically arranged on the upper surface and the lower surface of the single-layer PCB substrate, and phase regulation and efficient transmission are achieved by adjusting unit structure parameters; the biological tissue model is of a two-layer structure attached to the Huygens metasurface array, electromagnetic waves emitted by the feed source antenna are subjected to phase compensation regulation and control through the Huygens metasurface array, and then near-field focusing is achieved on the surface layer of the biological tissue, so that the electric field intensity, the SAR value and the temperature of a target area reach design threshold values respectively, and the target area is obtained. And local precise heating of electromagnetic resonance and phase regulation is formed. According to the invention, an efficient, stable and easy-to-implement technology is provided for local precise heating in microwave hyperthermia.

A method for efficiently improving the microwave sterilization efficiency of packaged food adopts a conveyor belt tunnel type microwave treatment box to treat the packaged food, the conveyor belt tunnel type microwave treatment box comprises a heating section and a constant-temperature sterilization section, the two sections are respectively provided with magnetrons (microwave tubes) with different numbers according to actual requirements, and a plurality of microwave feed inlets and a plurality of temperature measurement control points are reasonably arranged; the temperature rise section is controlled to gradually rise from the original temperature to the set sterilization temperature of 50-95 DEG C, and the constant-temperature sterilization section is subjected to temperature measurement and temperature control, so that microwave heating and cooling are in a dynamic balance state, the microwave power is automatically reduced when the temperature rises, and the microwave power is automatically increased when the temperature drops; the product in the constant-temperature sterilization section is always in a set temperature range of + / -2 DEG C, and the temperature control aims to measure the product temperature at the temperature measuring point and control the product temperature in the set temperature range; and each temperature measuring point is provided with an infrared temperature measuring probe and a microcomputer control system.

The invention relates to the technical field of non-invasive temperature measurement, in particular to a microwave hyperthermia ultrasonic non-invasive temperature measurement system based on an RNN-ARMB model, and the system comprises a microwave hyperthermia instrument. The waveguide antenna is connected with the output end of the microwave hyperthermia instrument, the microwave hyperthermia instrument feeds energy into the waveguide antenna, and the waveguide antenna generates heat; the B-type ultrasonic equipment is used for acquiring an ultrasonic image video; the computer is connected with the B-type ultrasonic equipment and used for receiving the ultrasonic image video collected by the B-type ultrasonic equipment and converting the ultrasonic image video into ultrasonic image data; the temperature is input into the trained RNN-ARMB model, and a predicted temperature is obtained; the system can synchronously predict the temperature at the moment while acquiring an ultrasonic image.

The invention provides a low-radiation high-directivity antenna structure for microwave hyperthermia, and relates to the technical field of medical microwave equipment antennas. Comprising an antenna radiator, two grounding metal columns, a metal substrate and a coaxial hose. The metal substrate is in sealed connection with one side of the microwave heating cavity, the two grounding metal columns are located in the microwave heating cavity, the grounding metal columns are perpendicular to the metal substrate and installed on the metal substrate, the two grounding metal columns are symmetrically arranged in a spaced mode, and the antenna radiator is parallel to the metal substrate and arranged on the upper portions of the grounding metal columns; and one end of the coaxial hose is connected with the antenna radiator, and the other end penetrates through the metal substrate, is positioned outside the microwave heating cavity and is used for externally connecting a solid-state microwave source. Through a reflecting surface structure formed by the elevated antenna radiator and the grounding metal column, the structure effectively inhibits sidelobe radiation and forms a concentrated main lobe by controlling a current return path and electromagnetic field distribution, so that microwave energy is accurately projected to a target tissue area, and the treatment depth and precision are improved.

The embodiment of the invention provides a microwave hyperthermia device for noninvasive measurement of tumor body temperature, and the device comprises a solid-state microwave source, and the bottom of one end of the solid-state microwave source is provided with a connector in an embedded manner; the microwave conduction device is fixedly installed in the connector, a treatment application device is installed at the bottom end of the microwave conduction device, and the treatment application device is connected with the solid-state microwave source through the microwave conduction device and the connector; the detection frame is fixedly mounted on one side of the solid-state microwave source, a plurality of microwave imaging devices are mounted in the detection frame, each microwave imaging device comprises a mounting seat, a microwave emission head and a receiving probe, the mounting seat is fixedly mounted in the detection frame, the microwave emission head is mounted at one end of the mounting seat in an embedded manner, and the receiving probe is mounted at the other end of the mounting seat. The microwave imaging device is adopted to carry out non-contact imaging scanning and temperature measurement on a focus, temperature distribution data images of the surface and the interior of a tumor are directly obtained, and accurate tumor positioning is achieved by fusing the temperature distribution data images with CT and nuclear magnetic resonance examination results.

The invention provides application of a polyamino acid material in tumor microwave hyperthermia sensitization. The polyamino acid material is applied to the field of tumor microwave hyperthermia sensitization for the first time, and the polyamino acid material can specifically target tumors based on excellent biological safety, specific tumor targeting and good microwave sensitization, so that a tumor area can be selectively heated, and the cancer treatment efficiency is remarkably improved. Potential physiological toxicity to an organism is not generated while an excellent tumor treatment effect is achieved, and good clinical application value is achieved.

The invention provides a composite scaffold material and a preparation method and application thereof, and relates to the technical field of composites.The preparation method comprises the steps that ferric chloride hexahydrate and anhydrous sodium acetate are added into ethylene glycol for a reaction, and Fe3O4 nanoparticles are obtained; potassium ferricyanide and a dispersion medium are added into a hydrochloric acid solution to be dissolved, then Fe3O4 nanoparticles are added for a reaction, and a Fe3O4 / PB heterojunction is obtained; the preparation method comprises the following steps: mixing and grinding a Fe3O4 / PB heterojunction and poly-L-lactic acid, and carrying out laser printing to form the PLLA-Fe3O4 / PB microwave antibacterial composite scaffold material. PLLA is taken as a carrier, the Fe3O4 / PB heterostructure scaffold material is loaded, the microwave absorption performance is enhanced through a magnetic-dielectric synergistic effect, under microwave irradiation, by virtue of a dual mechanism of interface polarization and dipole polarization, the composite scaffold material is prepared into the PLLA-Fe3O4 / PB microwave antibacterial composite scaffold material, and the composite scaffold material is prepared into the PLLA-Fe3O4 / PB microwave antibacterial composite scaffold material. Microwave thermal therapy and microwave power are synchronously realized, and the microwave thermal therapy and the microwave power synergistically show an efficient antibacterial effect on the osteomyelitis infected by the staphylococcus aureus.

The invention discloses a magnetic response nano-motor for microwave hyperthermia and a preparation method and application of the magnetic response nano-motor. The magnetic response nano motor is formed by compounding boron nitride and a zeolite imidazole skeleton (ZIF-67), is of a regular dodecahedron structure, has the particle size of 700-900 nm, and has magnetic responsiveness and microwave absorption heating performance. When in use, the nano motor is injected into a human body and then is guided to be enriched in a tumor area through an external magnetic field, and electromagnetic energy is converted into heat energy under microwave irradiation, so that local thermal killing of tumors is realized. The nano motor is simple in preparation process, shows good magnetic response performance and microwave thermal therapy effect, and is suitable for tumor drug delivery and / or tumor cell thermal killing.

The invention provides a microwave hyperthermia sensitization polyamino acid material. The polyamino acid material is selected from at least one of polyamino acid, polyamino acid salt or polyethylene glycol modified polyamino acid. According to the polyamino acid material provided by the invention, the microwave heat production temperature is remarkably increased by 5-8 DEG C compared with that of a traditional mode, and the excellent biological safety of the material is utilized to realize the application of efficient fat decomposition, so that the core problems of low fat dissolving efficiency and insufficient energy conversion rate in an existing microwave fat dissolving technology are solved; finally, the purposes of reducing treatment times and improving clinical effects are achieved.

The present application belongs to the technical field of medical devices, and specifically relates to a microwave thermotherapy device suitable for acupuncture, aiming to solve the problem of lack of special safety protection for microwave thermotherapy after acupuncture. The device comprises a microwave thermotherapy module, a metal detection module, a control module, a position confirmation module, a prompt module, a support module and a driving module; the position confirmation module comprises double detection units, which are matched with light supplementing and distance measuring components to realize consistency confirmation of detection and thermotherapy areas and real-time displacement monitoring. The metal detection module checks the metal of the affected area, the control module links all the modules, and the microwave thermotherapy module is prohibited from working when the metal detection is unqualified or the position deviation occurs, and the prompt module gives a prompt. The device has reasonable structure, convenient operation and accurate detection, can effectively avoid the risk of burns caused by metal residues, is suitable for the clinical scene of microwave thermotherapy after acupuncture, and provides reliable support for clinical treatment.

The invention discloses a microwave hyperthermia phased array excitation optimization method based on an adaptive multi-target particle swarm algorithm, and the method comprises the following steps: 1, taking each antenna unit in a phased array as an individual, building a population, setting an optimization target for the population, and initializing the position and speed of each individual; 2, simulation is conducted according to the positions of all the individuals, electromagnetic energy field distribution is obtained, and the specific absorption rate is obtained through calculation based on the electromagnetic energy field distribution; 3, calculating a target function according to the optimization target; 4, searching a non-inferior solution and updating a population optimal value according to the target function value; 5, adaptively adjusting the speed of the individual according to the difference value between the optimal solution of the population and the optimization target, and updating the position of the individual according to the adjusted speed of the individual; step 6, judging whether the optimal solution of the population meets an optimization target or the number of iterations reaches an upper limit, if so, outputting the optimal solution, and if not, executing the step 2; and 7, adjusting phased array excitation according to the optimal solution.

The present application relates to the technical field of experimental animal hyperthermia, and discloses a microwave hyperthermia target area temperature constant control and regulation system for experimental animals. The signal response module of the system responds to a microwave hyperthermia control signal; the temperature data acquisition module acquires temperature data of multiple preset positions in the target area in real time; the initial state determination module determines the starting temperature of the target area based on the temperature data; the threshold comparison module compares the residual temperature difference corresponding to the starting temperature with a preset threshold; when the residual temperature difference is less than or equal to the preset threshold, the first control execution module controls the output power of the microwave emitter by using a first control strategy; when the residual temperature difference is greater than the preset threshold, the second control execution module divides the hyperthermia process into multiple time windows and applies different control strategies. The system can improve the temperature control precision and stability of the target area and meet the experimental requirements.

The invention discloses a multifunctional body position fixing auxiliary device for tumor microwave hyperthermia, a fixing device comprises an angle adjusting assembly which is arranged on a supporting device and is used for adjusting the angle according to the head of a patient, and the top end of the angle adjusting assembly is fixedly provided with a fixing assembly for fixing the head; a rotating assembly for driving the head to rotate is arranged in the fixing assembly, so that the movable plate I is unfolded and flatly placed on the movable mattress, and a patient lies on the movable plate to prevent displacement of the fixing plate; after the supporting block of the second movable plate is unfolded, the patient is placed, and the head is placed in the supporting ring; the hinge plate is rotationally matched with the support plate slot to adjust the body angle; the driving assembly moves the mattress to position the neck below the radiator; the motor drives the supporting ring to rotate the head at a constant speed along the arc groove through gear transmission, and uniform thermal therapy is ensured. The connecting rod rotates to control the radiator to be close to the supporting block for microwave thermal therapy, the head is kept stable in the whole process, and treatment precision and comfort are improved.

The invention discloses a tumor microwave heating device, and belongs to the technical field of biomedical engineering and microwave thermal therapy. The device includes a microwave heat source, a near field metasurface lens (MSL), and a dielectric anti-reflection layer (AR). The MSL is composed of a plurality of four-layer metal-medium sub-wavelength units which are distributed according to a hyperbolic phase and used for focusing microwave energy to a deep tumor target region in a biological tissue under the working frequency of 3 GHz; the AR layer is arranged between the MSL and the tissue, is designed based on a quarter wavelength conversion principle and is used for matching impedance of air and multi-layer biological tissue (skin / fat / muscle). Through the synergistic effect of MSL and AR, the device significantly reduces interface reflection (about 35 dB), and realizes highly localized energy deposition in a tumor area, so that the average specific absorption rate (SAR) is improved by 9.7 times, and the efficiency, precision and safety of microwave hyperthermia are greatly improved.

The embodiment of the application provides a kind of non-invasive ablation microwave thermotherapy device, belong to biomedical engineering industry in the microwave thermotherapy equipment technical field, including rack, solid microwave source, microwave transmission device, phased array microwave radiator, non-invasive temperature measuring device, treatment bed and positioning device. Through the three-dimensional coordinates of focus output by positioning device, drive treatment bed to complete lifting and horizontal displacement, make focus accurate alignment focusing area of phased array microwave radiator;Through the temperature data of non-invasive temperature measuring device, adjust output power or the phase distribution of phased array microwave radiator, realize positioning-ablation-real-time temperature measurement-regulation and control collaborative treatment. The whole treatment is without puncture insertion tissue, reduce patient wound, solve the technical defects that traditional microwave thermotherapy device cannot be realized in computer control phased array microwave under microwave imaging and CT, nuclear magnetic resonance image guidance, through microwave non-invasive temperature measurement at the same time through phased array rectangular microwave ablation treatment.