Nanoscale hot seed material for microwave tumor thermotherapy and preparation method thereof

A seed and tumor technology, applied in the field of biomedical materials science, can solve the problems of inaccurate positioning, unstable performance, low heat production efficiency, etc., and achieve the effect of strong microwave thermal effect

Inactive Publication Date: 2013-04-24
SHANDONG JIANZHU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key technical issue of targeted positioning microwave hyperthermia is the microwave heat seed material. The performance, heat production efficiency and temperature control of the heat seed material affect the application of microwave targeted hyperthermia. Although many material systems and tissue temperature measurement techniques have been reported It is used for targeted microwave tumor hyperthermia, but there are problems such as inaccurate positioning, low heat generation efficiency, unstable performance, and high price.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) First prepare hexagonal barium ferrite, the reagents required for the reaction are all commercially available, and no purification treatment is carried out before use, and the metal cations required in the preparation reaction come from barium nitrate Ba(NO 3 ) 2 ·6H 2 O and iron nitrate Fe(NO 3 ) 3 9H 2 O. According to barium nitrate: ferric nitrate=1:12 (molar ratio), weigh barium nitrate and ferric nitrate, dissolve in citric acid solution respectively, the molar ratio of citric acid and metal cation is 1:1. After a few minutes, a uniform and transparent mixed solution was obtained, and a certain amount of ammonia water was dropped into the mixed solution to adjust the pH value to 7. Electromagnetic stirring for 2 hours, aging at room temperature for 8 hours, the mixed solution was placed in a water bath at 80°C for 3 hours to form a sol, and then moved into a drying oven at 120°C to dry for 1-2 days until a xerogel was formed. The dried gel was placed in a...

Embodiment 2

[0023] (1) First prepare hexagonal barium ferrite, the reagents required for the reaction are all commercially available, and no purification treatment is carried out before use, and the metal cations required in the preparation reaction come from barium nitrate Ba(NO 3 ) 2 ·6H 2 O and iron nitrate Fe(NO 3 ) 3 9H 2 O. According to barium nitrate: ferric nitrate=1:12 (molar ratio), weigh barium nitrate and ferric nitrate, dissolve in citric acid solution respectively, the molar ratio of citric acid and metal cation is 1:1. After a few minutes, a uniform and transparent mixed solution was obtained, and a certain amount of ammonia water was dropped into the mixed solution to adjust the pH value to 7. Stir electromagnetically for 2 hours, age at room temperature for 6 hours, place the mixed solution in a water bath at 80°C for 3 hours to form a sol, and then move it into a drying oven at 120°C to dry for 1-2 days until a xerogel is formed. The dried gel was placed in a sinte...

Embodiment 3

[0028] (1) First prepare hexagonal barium ferrite, the reagents required for the reaction are all commercially available, and no purification treatment is carried out before use, and the metal cations required in the preparation reaction come from barium nitrate Ba(NO 3 ) 2 ·6H 2 O and iron nitrate Fe(NO 3 ) 3 9H 2 O. According to barium nitrate: ferric nitrate=1:12 (molar ratio), weigh barium nitrate and ferric nitrate, dissolve in citric acid solution respectively, the molar ratio of citric acid and metal cation is 1:1. After a few minutes, a uniform and transparent mixed solution was obtained, and a certain amount of ammonia water was dropped into the mixed solution to adjust the pH value to 7. Electromagnetic stirring for 2 hours, aging at room temperature for 12 hours, placing the mixed solution in a water bath at 80°C for 3 hours to form a sol, and then moving it into a drying oven at 120°C to dry for 2 days until forming a xerogel. The dried gel was placed in a si...

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PUM

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Abstract

The invention discloses a nanoscale hot seed material for microwave tumor thermotherapy. The nanoscale hot seed material for microwave tumor thermotherapy is nano-powder having uniform particle sizes, is prepared by high-temperature hot-press sintering and high-energy ball-milling grinding refining and comprises 50 to 80wt% of hexagonal-system barium ferrite, 5 to 15wt% of magnesium oxide, 1 to 5wt% of titanium oxide and the balance silicon oxide. The preparation method comprises the following steps of preparing hexagonal-system barium ferrite nano-power, respectively weighing the hexagonal-system barium ferrite nano-power, magnesium oxide power, titanium oxide power and silicon oxide power according to the above weight ratio, carrying out high-energy ball milling for full dispersion, filling the dispersed power into a graphite grinding tool, carrying out sintering in a hot-press sintering furnace, carrying out mechanical pulverization of the composite material obtained by sintering, and carrying out high-energy ball milling to obtain the nano-power which is the nanoscale hot seed material. The nanoscale hot seed material has strong microwave heating effects in a tumor microwave frequency range and can be used for tumor microwave targeting thermotherapy.

Description

technical field [0001] The invention relates to a nano thermal seed material based on microwave tumor hyperthermia and its preparation method, in particular to a nano-hexagonal barium ferrite and oxides such as magnesium oxide, which are obtained through hot pressing sintering and ball milling refinement processes. A nano thermal seed material and a preparation method thereof. The invention belongs to the field of biomedical material science. Background technique [0002] With the increasing incidence and mortality of cancer year by year, the research on the diagnosis and treatment of tumor diseases has attracted more and more attention. In the treatment of tumors, the biggest difficulty is to ensure that tumor cells are killed without causing damage to normal cells or tissues. Microwave targeted hyperthermia uses microwave heat seed materials to heat tumor cells in the tumor area using the microwave heat effect of heat seed materials. To 43-47 ℃, and lead to apoptosis of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/26C04B35/622A61K41/00A61P35/00
Inventor 孙昌孙康宁李静李阳刘科高石磊
Owner SHANDONG JIANZHU UNIV
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