Self-assembly hyaluronic acid-indissolvable prodrug-coated active medicine-encapsulated liposome nano administration system and preparation method thereof
A technology of hyaluronic acid and active drugs, which is applied in the field of self-assembled nano-liposome complex and its preparation, to achieve the effect of improving anti-tumor ability, reducing toxic and side effects, and improving targeting
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Embodiment 1
[0024] prescription:
[0025] Hyaluronic Acid-Paclitaxel Prodrug 10mg
[0026] Temperature Responsive Liposomes 20mg
[0027] Marimastat 1mg
[0028] Preparation:
[0029] A temperature-responsive liposome loaded with 1 mg of Marimastat was prepared by thin film dispersion-probe ultrasonic method, ready for use. Add 10 mg of hyaluronic acid-paclitaxel prodrug into the temperature-responsive liposome solution loaded with 1 mg of Marimastat, and vortex for half a minute. The mixed solution of hyaluronic acid-prodrug and temperature-responsive liposomes loaded with 1 mg Marimastat was left to stand to obtain self-assembled hyaluronic acid-poorly soluble prodrug-coated liposome nano-administration of active drugs system.
[0030] Utilize the particle size of the liposome nano drug delivery system of the self-assembled hyaluronic acid-poorly soluble prodrug coating of embodiment 1 prepared by dynamic light scattering nano particle size meter, polydispersity coefficient, The Z...
Embodiment 2
[0032] prescription:
[0033] Hyaluronic Acid-Paclitaxel Prodrug 10mg
[0034] Temperature-responsive cationic liposome 20mg
[0035] Preparation:
[0036] The temperature-responsive cationic liposome was prepared by thin film dispersion-probe ultrasonic method, ready for use. Add 10 mg of hyaluronic acid-paclitaxel prodrug into the temperature-responsive cationic liposome solution, and vortex for half a minute. The mixed solution of hyaluronic acid-prodrug and temperature-responsive cationic liposome is left to stand to obtain a self-assembled hyaluronic acid-poorly soluble prodrug-coated liposome nano drug delivery system coated with active drugs.
Embodiment 3
[0038] prescription:
[0039] Hyaluronic Acid-Paclitaxel Prodrug 10mg
[0040] Long Circulation Liposomes 20mg
[0041] Preparation:
[0042] Prepare long-circulating liposomes by thin film dispersion-probe ultrasonic method, ready for use. Add 10 mg hyaluronan-paclitaxel prodrug to the long-circulating liposome solution and vortex for half a minute. The mixed solution of hyaluronic acid-prodrug and long-circulation liposome is left to stand to obtain a self-assembled hyaluronic acid-poorly soluble prodrug-coated liposome nano drug delivery system coated with active drugs.
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