Extraction process of resveratrol from giant knotweed

A technology of resveratrol and Polygonum cuspidatum, which is applied in the field of preparation of resveratrol extracted from Polygonum cuspidatum plants, can solve the problems of unsatisfactory industrialization degree of yield and output, and achieve tight process, reduce consumption, and operate easy effect

Inactive Publication Date: 2002-12-11
杨建文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, in the current technical solutions and patent documents, the separation of resveratrol and polydatin is considered as the separation target, and Polygonum cuspidatum is not enriched to a higher content by synthetic means before resveratrol is enriched. Purification, so the industrialization degree of its yield and output is still unsatisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Grind the dried Polygonum cuspidatum raw material, use ethanol and ethyl acetate according to its volume ratio of 1:1 to combine heating and reflux extraction for 3 times, the amount of extraction solvent is respectively 3 times, 2 times and 1 time of the raw material according to its volume ratio, extract The time is 3: 2: 1 hour, combine the extracts and recover the organic solvent under reduced pressure, distill and concentrate to a thick paste; add 10 times the amount of water to the obtained thick paste according to its volume ratio, and heat it to the boiling point Stand still for 1 hour, pour out the supernatant when the temperature is not lower than 50°C, and concentrate to 30B°C (Baume degree); the obtained dilute solution with a Baume degree of 30B°C, according to its volume ratio, is respectively Add ethyl acetate in multiples of 3:2:2, extract three times and combine the extracts, adjust the pH value to 8.0 with concentrated ammonia water, let stand, filter, ...

Embodiment 2

[0029] Grind the dried Polygonum cuspidatum raw material, use ethanol and ethyl acetate according to its volume ratio of 1:1 to combine heating and reflux extraction for 3 times, the amount of extraction solvent is respectively 4 times, 3 times and 2 times of the raw material according to its volume ratio, extract The time is 3: 2: 1 hour, combine the extracts and recover the organic solvent under reduced pressure, distill and concentrate to a thick paste; add 15 times the amount of water to the obtained thick paste according to its volume ratio, and heat it to the boiling point Stand still for 2 hours, pour out the supernatant when the temperature is not lower than 50°C, and concentrate to 35B°C (Baume degree); the obtained diluted solution with a Baume degree of 35B°C, according to its volume ratio, is respectively Add ethyl acetate in multiples of 4:3:3, extract three times and combine the extracts, adjust the pH value to 9.0 with concentrated ammonia water, let stand, filte...

Embodiment 3

[0031] Grind the dried Polygonum cuspidatum raw material, use ethanol and ethyl acetate according to its volume ratio of 1:1 to combine heating and reflux extraction for 3 times, the amount of extraction solvent is respectively 5 times, 4 times and 3 times of the raw material according to its volume ratio, extract The time is 3: 2: 1 hour, combine the extracts and recover the organic solvent under reduced pressure, distill and concentrate to a thick paste; add 20 times the amount of water to the obtained thick paste according to its volume ratio, and heat it to the boiling point Stand still for 3 hours, pour out the supernatant when the temperature is not lower than 50°C, and concentrate to 40B°C (Baume degree); Add ethyl acetate in multiples of 5:4:4, extract three times and combine the extracts, adjust the pH value to 10.0 with concentrated ammonia water, let stand, filter, concentrate under reduced pressure to 1 / 20 of the volume of the extract, and crystallize The crude ext...

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PUM

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Abstract

During the extraction of resveratrol from giant knotwood, giant knotwood glycoside is hydrolyzed and enriched through organic synthesis. The extraction process includes mixing giant knotwood raw material and composite stuffing, high pressure chromatography in a high-pressure chromatographic column apparatus, gradient elution with chloroform and ethyl acetate and thin chromatographic tracking detection. The said process can reach a kilogram level yield and high product purity. The present invention may be used in extracting resveratrol and other similar product from giant knotwood material.

Description

Technical field: [0001] The invention relates to a method for extracting resveratrol, in particular to a preparation method for extracting resveratrol from Polygonum cuspidatum. Background technique: [0002] In the current technical scheme, resveratrol is mainly completed by the method of chemical synthesis, but because of its large investment in equipment, complicated process, high cost and low yield, it is unsatisfactory. In recent years, people have tried to extract resveratrol from the natural plant Polygonum cuspidatum and have made gratifying progress. Polygonum cuspidatum is a traditional Chinese herbal medicine in my country, which contains a large amount of polydatin (also known as resveratrol glycoside) and resveratrol, and resveratrol is a natural active substance that has a significant curative effect on human health. It has attracted widespread attention from the international community. It has been proved by scientific research and clinical application that r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/68C07C39/21
Inventor 成小飞
Owner 杨建文
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