43 results about "Organic Synthesis Methods" patented technology

The invention provides a bissanthin aromatic ring bay region C-H nucleophilic substitution reaction method and application thereof, and belongs to the field of organic synthesis methodology. According to the reaction, bissanthin is used as a raw material, dichloromethane and acetonitrile are used as solvents, and the bissanthin is oxidized by nitrite hexafluorotellurate and respectively reacts with nucleophilic reagents such as carbon anions, oxygen-containing reagents, sulfur-containing reagents, chlorine-containing reagents, nitrogen-containing reagents, phosphorus-containing reagents and cyano groups in one step to synthesize a series of bissanthin bay area modified functionalized products; when the reaction method is further applied to the nucleophilic substitution reaction of two molecules, namely perylene (Perylene) and N, N '-di (1, 3-diisopropyl benzene)-3, 4, 9, 10-perylene dicarboximide (PDI), good universality is shown, and the reaction method can be applied to the nucleophilic substitution reaction of two molecules, namely perylene (Perylene) and N, N'-di (1, 3-diisopropyl benzene)-3, 4, 9, 10-perylene dicarboximide (PDI). The method is mild in reaction condition, does not need to introduce transition metal as a catalyst, is easy in product separation and purification, and has the advantages of low cost, high efficiency and greenness; the series of functionalized derivatives constructed by the method can provide important intermediates for synthesis of larger polycyclic aromatic hydrocarbon molecules of the system; the method has a good industrial production prospect.

The invention discloses a cationic amine collecting agent which has the following structure: # imgabs0 #. The invention further discloses a preparation method of the cationic amine collecting agent and application of the cationic amine collecting agent in lepidolite flotation, an organic synthesis method is applied, a group-carboxyl group in an anionic collecting agent is introduced into the cationic amine collecting agent, and the cationic amine collecting agent is obtained. The novel collecting agent for lithium ore flotation is designed and synthesized, higher activity and selectivity are achieved in the aspect of target mineral collection, and the concentrate grade and the recovery rate of lithium ore can be remarkably improved.

The present invention relates to a method for synthesizing a novel primary amide using dioxazolone as a starting material and adding a copper salt catalyst, and more specifically, to a method for producing an environmentally friendly primary amide derivative with a short reaction time, low reaction temperature, and the generation of harmless carbon dioxide as a byproduct. The present invention provides an efficient method that enables the safety of compounds and low-cost synthesis even in large-scale reactions. Furthermore, it suppresses the use of highly corrosive ammonia, which was required in the conventional synthesis of primary amides, while simultaneously providing more environmentally friendly synthesis conditions through a water-added co-solvent system. Furthermore, the organic synthesis method of primary amides according to the present invention can be widely applied to the synthesis of pharmaceutical intermediates, natural products, and low-molecular-weight new drug candidate compounds.

The invention discloses a synthesis method of a pimozide intermediate, and relates to the field of organic synthesis methods and electrochemical catalysis. The technical problem that in the prior art, non-activated olefin and aryl halide are efficiently coupled to generate 4, 4-bis (4-fluorobenzene) chlorobutane is solved. The method comprises the following steps: reducing a nickel catalyst through a constant current in an inert gas atmosphere by utilizing an electrochemical catalysis means, carrying out an oxidative addition reaction on the reduced nickel catalyst and aryl halide, then adding the reduced nickel catalyst to non-activated olefin, and carrying out a nickel migration reaction to form the aryl-shifted nickel compound intermediate. According to the method, the synthesis steps are greatly reduced, the reaction efficiency and selectivity are improved, especially when the pimozide intermediate is synthesized, the production cost can be remarkably reduced, the reaction time can be remarkably shortened, and higher industrial application potential is shown. The pimozide intermediate prepared by the invention is used in the field of chronic mental disorder treatment.

The application relates to a method for synthesizing 1,1-bisaryl compounds by using non-activated alkenes, and belongs to the fields of organic synthesis methods and electrochemical catalysis. The application solves the technical problem that the existing reaction technology cannot realize efficient coupling of non-activated alkenes and halogenated arenes to generate 1,1-bisaryl compound products. In the application, a nickel catalyst is reduced on a cathode by a constant current under an inert gas atmosphere, then a secondary oxidative addition is carried out with another halogenated arene, and finally a 1,1-bisaryl compound product is generated through a reductive elimination step. The nickel catalyst circulates in the reaction by maintaining its valence state under electrochemical conditions, effectively avoiding the use of an additional chemical reducing agent, simplifying the operation and reducing the environmental burden. The reaction system of the application has high efficiency and universality, and can be applied to various halogenated arenes and non-activated alkenes under mild conditions, and has significant application value in the modification and synthesis of natural products and drug molecules.

A low-carbon and environment-friendly method for synthesizing a primary amine from a halogenated hydrocarbon in the technical field of organic synthesis is provided. The method includes adding formaldehyde and ammonia in an alcohol solution at a ratio of 8 mol:8 mol for a full reaction, then adding 3 mol of the halogenated hydrocarbon at a suitable temperature, followed by a full reaction, and performing a series of post-treatment steps to obtain a target primary amine product with relatively high purity.

The invention discloses a 2-azabicyclo [3.1. 1] heptene derivative as well as a synthesis method and application of the 2-azabicyclo [3.1. 1] heptene derivative. The 2-azabicyclo [3.1. 1] heptene derivative provided by the invention is obtained by exciting a rhodium complex by visible light to catalyze bicyclo [1.1. 0] butane to perform cycloaddition reaction. The 2-azabicyclo [3.1. 1] heptene derivative constructed by the method can be applied to the aspects of simulating bioisosteres and the like, is expected to obtain more innovative achievements in the field of organic synthesis methodology, and also can provide a brand new thought and a structural basis for developing novel drug molecules; and the medicine with better curative effect and less side effect can be designed.

The invention relates to a quinoxaline derivative containing trimethyl and n-propyl as well as a preparation method and application of the quinoxaline derivative, and the derivative is 1, 6, 7-trimethyl-3-propyl quinoxaline-2 (1H)-ketone and is particularly suitable for inhibiting fusarium oxysporum. The derivative is prepared by an organic synthesis method which comprises the step of carrying out cyclization reaction on N-protected o-phenylenediamine and a carbonyl compound in the presence of trifluoroacetic acid. Experiments show that the compound has a remarkable antibacterial effect on fusarium oxysporum, and the minimum inhibitory concentration is 0.50 mg / mL. The derivatives can destroy the cell membrane structure of fusarium oxysporum and cause leakage of RNA, protein and reducing sugar in cells, so that the growth of thalli is inhibited. The invention provides a theoretical basis and an experimental basis for developing a novel efficient and low-toxicity bacteriostatic agent.

The invention discloses a halogen carbazole derivative as well as an organic synthesis method and application thereof, and belongs to the field of organic room-temperature phosphorescent materials, the organic synthesis method of the carbazole derivative comprises the following steps: reacting 1, 3-dibromo-2, 4-difluoro-benzene with carbazole or a carbazole derivative to obtain a halogen-substituted carbazole derivative; cuprous iodide and 1-butylimidazole are adopted as a catalytic system, under the oxidation action of potassium ferrocyanide, bromine substituent in the obtained carbazole derivative is converted into cyano through nucleophilic substitution reaction, and the cyano-substituted carbazole derivative is obtained. The carbazole derivative prepared by the method is long in afterglow time and good in thermal stability.

The invention belongs to the technical field of organic synthesis methodology, and particularly relates to a photoinduced beta-cyano sulfone compound synthesis method based on a triarylamine electron donor acceptor compound and application of the photoinduced beta-cyano sulfone compound. According to the method, a substituted sulfonium salt serves as an electron acceptor, triarylamine serves as an electron donor to form an EDA compound, and under the action of visible light, the EDA compound is synthesized into a beta-cyano sulfone compound based on the triarylamine electron donor acceptor compound. The method comprises the following steps: by taking substituted cyanohydrin as a raw material and 4-diazabicyclo [2.2. 2] octane di (sulfur dioxide) adduct [(DABCO). (SO2) 2] as a sulfur source, adding an organic solvent, reacting in an inert gas at a certain temperature, and realizing a bifunctionalization process of olefin through far-end functional group migration, thereby obtaining the beta-cyano sulfone compound. The method does not need harsh reaction conditions, the reaction can be completed in one step, the reaction conditions are mild, and the method is green and environment-friendly. The beta-cyano sulfone compound and the derivative thereof prepared by the method are expected to be applied to the research and development fields of anti-cancer, antiviral and antibacterial medicines and the like.

The application belongs to the technical field of organic synthesis and relates to an organic synthesis method for benzyl protection of a hydroxyl group. The application provides an organic synthesis method for benzyl protection of a hydroxyl group, which comprises the following steps: dissolving benzyl chloride and KI in DMF, adding NaH, and then adding a DMF solution containing a substrate drop by drop to perform a temperature control reaction. The application provides a new idea for protection of a non-conventional hydroxyl group.

This invention discloses a method for preparing a seawater desalination evaporator based on an organic three-dimensional light-trapping and biomimetic suspension protection mechanism, including a. a synthesis route of small molecule photothermal materials; and b. a preparation process of the seawater desalination evaporator. This method for preparing a seawater desalination evaporator based on an organic three-dimensional light-trapping and biomimetic suspension protection mechanism uses low-cost wood pulp sponge as a matrix. The material is synthesized through a simple one-step organic synthesis method, dissolved in an organic solvent, and drop-coated onto the matrix to prepare a seawater desalination evaporator with a three-dimensional light-trapping and suspension protection mechanism. The evaporator preparation method provided by this invention enables more convenient, lower-cost, and higher-efficiency seawater desalination. The one-step high-yield organic synthesis method reduces the preparation cost of the evaporator.

The invention belongs to the technical field of organic synthetic chemistry, and discloses an efficient synthesis method of an indoline and azepine ketone derivative. The derivative has a structure as shown in a formula (I), and is prepared according to the following steps: reacting 1 equivalent of carboxylic acid, 1 equivalent of o-alkynylaniline, 1 equivalent of pyridine-2-formaldehyde and 1 equivalent of isocyanide as reaction raw materials at room temperature for 5 hours under the condition that methanol is used as a solvent to obtain an intermediate Ugi compound. Then, spin-drying a reaction solvent, adding n-butyl alcohol (1.5 mL), XPhosAuCl (0.01 mmol, 0.05 equivalent) and silver acetate (0.01 mmol, 0.05 equivalent), and transferring a reaction system to a microwave condition of 110 DEG C to react for 1 hour, so as to finally obtain the indoline and azepine ketone derivative as shown in the formula (I). The indoline azepine ketone derivative is efficiently prepared through a one-pot method, the compound is a quasi-natural product compound with a novel structure, and the developed organic synthesis method has the advantages of being high in atom economy, simple in step and the like. Meanwhile, the compound also shows good anti-tumor cell proliferation activity. # imgabs0 #

The application belongs to the technical field of organic synthesis, and discloses a method for preparing n-butyl ether and butyl phenyl ether simultaneously through etherification reaction. Phenol, n-butanol and a phosphoric acid catalyst are mixed, and then etherification reaction is carried out under a protective gas to obtain n-butyl ether and butyl phenyl ether. The method can prepare n-butyl ether and butyl phenyl ether simultaneously, the combined selectivity of n-butyl ether and butyl phenyl ether can reach 98-99%, the reaction has few by-products, the conversion efficiency of raw materials is high, the products obtained by the reaction are important chemical raw materials, and the method has high economic benefits. The preparation method does not need to add strong acid and strong base, the reaction condition is mild, the safety coefficient of the preparation process is high, there is no defect of damage and corrosion to the equipment, and the method belongs to a more green and environmental protection organic synthesis method.

The invention relates to the field of organic synthesis methodology, in particular to a quinazoline dihydroimidazole thione derivative and a preparation method and application thereof.The quinazoline dihydroimidazole thione derivative is prepared by reacting aryl glyoxal, o-aminobenzene amine, aryl isothiocyanate and an additive at a certain temperature under the closed condition and the solvent condition. The method has the characteristics that the catalyst is cheap and easy to obtain, the raw materials are easy to obtain, the operation is simple, the reaction time is short, the yield is relatively high, the functional group compatibility of the substrate is good, a series of quinazoline and dihydroimidazole thione derivatives can be synthesized, and the method has a good potential application value.

The invention relates to the technical field of organic synthesis methodology, in particular to a high-throughput screening method for polypeptide compound peptide bond construction, which comprises the following steps: step 1, using a 24-pore plate as an experimental carrier, constructing 6 * 4 reaction systems according to 6 condensation reagents and 4 solvents, the solvent corresponds to the solvent of the solution A and the solvent of the solution B; 2, adding the solution A containing the carboxyl substrate, a condensation reagent and organic alkali into the reaction container, and reacting at 10-40 DEG C for 0.5-4 hours; and 3, adding a solution B containing an amino substrate into the reaction container, and carrying out a stirring reaction at 0-100 DEG C for 10-30 h to obtain the polypeptide compound as shown in the formula I. According to the method, the application of a high-throughput screening method in the field of organic chemistry is enriched, the optimal reaction reagent for constructing the peptide bond of the target compound can be quickly determined in a short time, and the efficiency and purity of synthesizing the peptide bond are greatly improved.

The present invention relates to a substrate for solid-phase organic synthesis and a solid-phase organic synthesis method using the same. More specifically, the present invention relates to a substrate having a larger reactive surface area compared to conventional solid-phase resins, thereby improving the efficiency of solid-phase organic synthesis reactions, and also being applicable to continuous organic synthesis via a roll-to-roll process.

The invention relates to the technical field of organic synthesis, in particular to a method for preparing 2-methylbenzisothiazolin-3-one at room temperature through participation of NCS. In the prior art, 2-methylbenzisothiazolin-3-one is obtained through an organic synthesis method, the reaction conditions are relatively harsh, the steps are relatively complicated, and the production efficiency is relatively low. In order to solve the technical problem, the invention provides the method for preparing the 2-methylbenzisothiazolin-3-one by using N-chlorosuccinimide (NCS) at room temperature, which comprises the following steps: reacting the NCS serving as a key additive with 2-sulfydryl-N-methyl benzamide in a solvent under the condition of violently stirring at room temperature, thereby obtaining the 2-methylbenzisothiazolin-3-one. The 2-methylbenzisothiazolin-3-one is successfully prepared by using the 2-methylbenzisothiazolin-3-one as a raw material, and the synthetic method disclosed by the invention is more efficient, milder in reaction condition and better in application prospect.

The invention belongs to the field of organic synthesis methodology, and particularly relates to a method for synthesizing aryl ketone compounds by catalyzing aryl alkane to be directly oxidized at room temperature through visible light. A method for synthesizing aryl ketone compounds by catalyzing direct oxidation of aryl alkane at room temperature through visible light comprises the following steps: adding aryl alkane serving as a reaction substrate into a solvent, and reacting at room temperature by taking oxygen as an oxidizing agent and crystalline phase carbon nitride as a catalyst to obtain the aryl ketone compounds. Stirring and reacting for a certain time at room temperature under the irradiation of visible light with the wavelength of 425nm, and then selectively oxidizing aryl alkane to prepare the aryl ketone compound. Crystalline phase carbon nitride is used as a catalyst to catalyze and activate oxygen under visible light irradiation to generate superoxide radicals to grab hydrogen on aryl alkane, free radical activation of inert Csp3-H bonds is achieved, reaction conditions are mild and can be carried out at room temperature, a reaction solvent is green, environmentally friendly, low in price and easy to obtain, the yield of a target product is high, and the method is suitable for industrial production. The driving force of the reaction is visible light, and meets the development requirements of green chemistry.

The invention belongs to the technical field of organic synthesis methodology, and particularly relates to a visible light promoted aliphatic primary amine compound synthesis method and application, the method uses substituted sulfonium salt and substituted styrene as raw materials, ammonium thiocyanate as an amine source, alkali as an additive, an organic solvent is added, reaction is carried out in inert gas at a certain temperature, and the visible light promoted aliphatic primary amine compound is obtained. Under visible light, under the catalytic action of a metal copper complex, the aliphatic primary amine compound is prepared. The method is mild in reaction condition, safe, green and environment-friendly, can be completed in one step, and accords with atom economy and step economy. The aliphatic amine compound and the derivative thereof prepared by the method are expected to serve as lead compounds to be applied to the research and development fields of anti-tumor and antibacterial drugs and the like.

The invention relates to the field of organic synthesis methodology, in particular to a method for preparing amide through an imine compound. The method for preparing the amide from the imine compound comprises the following step: under the combined action of visible light irradiation, a catalyst and a deoxidizing reagent, acetic acid and the imine compound are subjected to a free radical addition reaction in an organic solvent to generate the amide compound. The amide compound is stable in structure and has certain biological activity. The amide functional group is not only an important constituent part for forming a living substance (such as protein), but also widely exists in many active drug intermediates (such as colchicine) or artificial materials (nylon), and plays an indispensable role. A traditional method for preparing an amide compound is characterized in that a carboxylic acid derivative (acyl halide or anhydride) and amine are mixed and react to prepare the amide compound. Compared with the prior art, the method has the remarkable advantages that the use of dangerous acyl halide reagents and the emission of corrosive and volatile gases are avoided; the experiment operation is simple. Therefore, the method for preparing the amide from the imine compound has important significance.

The invention belongs to the field of organic synthesis methods, and discloses an azo / deuterated imidazo buprofezin compound as well as a synthesis method and application thereof. According to the method, at the room temperature, aryl diazonium tetrafluoroborate or deuterium water, acryloyl chloride and 2-mercapto benzimidazole or 2-mercapto imidazole compounds are used as raw materials, and the azo / deuterated imidazo buprofezin compounds with medical application prospects are synthesized in the air atmosphere in the presence of alkali. Compared with a previously reported preparation method, the method has the advantages of being green, environmentally friendly, safe, efficient and energy-saving, the substrate application range is wide, the product functional group compatibility is good, raw materials are easy to obtain, operation is easy and convenient, and potential industrial application prospects are achieved.

The invention discloses di (propyl-2-alkenyl) furan-2, 5-dicarboxylate and a preparation method thereof, and relates to the technical field of biomass-based organic synthesis methods. According to the method, 2, 5-furandicarboxylic acid is taken as a base material, allyl is grafted on the 2, 5-furandicarboxylic acid through esterification reaction under the action of an inorganic metal catalyst, and the bis (propyl-2-alkenyl) furan-2, 5-dicarboxylate is obtained. Compared with a traditional synthesis method, required reaction conditions are mild, a high-temperature and high-pressure environment is not needed, the energy consumption is reduced, and the operation risk and the equipment cost are also reduced. The mild reaction conditions are more beneficial to keeping the activity and selectivity of the catalyst, and the reaction efficiency is improved. The obtained product is high in purity and can be directly used for subsequent application or further chemical conversion without complicated post-treatment steps, so that the overall production efficiency is improved. The invention provides a new thought for realizing high value-added utilization of biomass materials such as 2, 5-furandicarboxylic acid and the like.

The invention discloses a spiro pyrazolone compound, a preparation method and application, and belongs to the technical field of preparation and application of compounds. Specifically, a barbital diazo compound and a pyrazolone diazo compound are taken as reactants, a transition metal catalyst, an organic ligand and an organic solvent are added, a cross-coupling / spiro-cyclization cascade reaction is carried out under a heating reaction condition, and a target product is generated. The preparation method is mild in reaction condition, high in reaction speed, simple in post-treatment and good in substrate universality. According to the method, the spiro pyrazolone compound with antitumor activity can be obtained with high chemical yield and high chemical / regioselectivity, and an efficient and simple organic synthesis method and technology are provided for research and development of candidate drugs.

The invention discloses a preparation method of a steroid compound 4, 5-position epoxy compound, and relates to the technical field of organic matter synthesis methods, 17beta-hydroxy-2, 4-ene-androstane [2, 3-d] isoxazole, a medium polar solvent, hydrogen peroxide and an anhydride reagent are used as raw materials for reaction, then alcohol recrystallization is carried out, and the compound 4, 5-position epoxy compound is obtained. Finally, a target product, namely the 4 alpha, 5 alpha-epoxy-17 beta-hydroxyl-2-ene-androstane [2, 3-d] isoxazole, is obtained. The medium polar solvent comprises dichloromethane and chloroform; the anhydride reagents are acetic anhydride and acetic acid. The preparation method provided by the invention has the advantages of short process reaction time and few byproducts, is favorable for improving the purity of the product, and has important guiding significance for the synthesis of subsequent derivative products.

The invention belongs to the field of nano material preparation, and particularly relates to a two-dimensional conductive metal phthalocyanine organic framework nanosheet as well as a preparation method and application thereof. An organic ligand 2, 3, 9, 10, 16, 17, 23, 24-octahydroxy metal phthalocyanine containing a metal phthalocyanine unit is synthesized by adopting an organic synthesis method, and a two-dimensional metal phthalocyanine-organic framework is further synthesized by utilizing a solvothermal reaction of the ligand and a metal salt of acetylacetone. Stripping the two-dimensional metal phthalocyanine organic framework by adopting a ball milling method to obtain a two-dimensional metal phthalocyanine organic framework nanosheet; the two-dimensional metal phthalocyanine organic framework nanosheet is used for modifying a substrate electrode to obtain the electrode modified by the two-dimensional metal phthalocyanine organic framework nanosheet, and the electrode is used for constructing an electrochemical sensor for detecting dopamine, uric acid, 5-hydroxytryptamine and ascorbic acid and has an extremely low detection limit. By improving the conductivity of the organic framework material and increasing active sites, the sensitivity and resolution of electrochemical detection are improved.

The invention belongs to the technical field of organic synthesis methodology, and particularly relates to a method for synthesizing allene nitrile compounds based on a visible light / metal copper dual-catalysis strategy and application of the allene nitrile compounds. According to the method, substituted sulfonium salt and substituted enyne are used as raw materials, trimethylsilyl cyanide is used as a cyano source, alkali is used as an additive, and an organic solvent is added; and reacting in inert gas at a certain temperature, and preparing the allene nitrile compound under the dual catalytic action of the photocatalyst and the metal copper / ligand catalyst. The method does not need harsh reaction conditions, the reaction can be completed in one step, the reaction conditions are mild, and the method is green and environment-friendly. The allene nitrile compound and the derivative thereof prepared by the method are expected to serve as lead compounds to be applied to the research and development fields of anti-cancer, antiviral and antibacterial drugs and the like.

The application discloses a kind of di (propyl-2-alkenyl) furan-2, 5-dicarboxylic acid ester and preparation method thereof, it is related to biomass-based organic synthesis method technical field.The method with 2, 5-furan dicarboxylic acid as base material, by esterification reaction under the action of inorganic metal catalyst, will be grafted in 2, 5-furan dicarboxylic acid on allyl, obtains di (propyl-2-alkenyl) furan-2, 5-dicarboxylic acid ester.Compared with traditional synthesis method, the required reaction condition is relatively mild, without high temperature and high pressure environment, not only reduce energy consumption, also reduce operating risk and equipment cost.Mild reaction condition is also more conducive to keeping the activity and selectivity of catalyst, improves reaction efficiency.The obtained product is high in purity, without complex post-processing step can be directly used in subsequent application or further chemical conversion, improves overall production efficiency.The application provides a new idea for 2, 5-furan dicarboxylic acid and other biomass materials to realize high value-added utilization.

The application discloses an environment-friendly synthesis method of 28-homobrassinolide, wherein (2,22)-diene-24S-ethyl-5alpha-cholesta-6-ketone P1 is used as a starting material, double bonds on a ring of P1 are simultaneously epoxidized, namely, double epoxidation, ring opening, acetylation, one-time hydrolysis and two-time hydrolysis are carried out to obtain a tetrahydroxy compound, and finally, lactonization is carried out to obtain the target 28-homobrassinolide. The 28-homobrassinolide is synthesized by a brand-new organic synthesis method, which is energy-saving, efficient, environment-friendly, simple in process and good in industrial application value.

The present invention provides a targeted near-infrared fluorescent compound and a preparation method and application thereof, and relates to the technical field of near-infrared fluorescent molecules. The targeted near-infrared fluorescent compound has a structure as shown in the following formula I. The S0456 near-infrared small molecule modified on a COX-2 inhibitor by an organic total synthesis method of the present invention obtains a targeted near-infrared fluorescent compound as shown in formula I. The targeted near-infrared fluorescent compound has a good active targeting effect when identifying COX-2 overexpressing liver tumors; and the targeted near-infrared fluorescent compound retains the water solubility of the dye and the specificity for tumor cells, and has the advantages of good water solubility and high fluorescence quantum yield.