15 results about "Organic Synthesis Methods" patented technology

The present invention relates to a method for synthesizing a novel primary amide using dioxazolone as a starting material and adding a copper salt catalyst, and more specifically, to a method for producing an environmentally friendly primary amide derivative with a short reaction time, low reaction temperature, and the generation of harmless carbon dioxide as a byproduct. The present invention provides an efficient method that enables the safety of compounds and low-cost synthesis even in large-scale reactions. Furthermore, it suppresses the use of highly corrosive ammonia, which was required in the conventional synthesis of primary amides, while simultaneously providing more environmentally friendly synthesis conditions through a water-added co-solvent system. Furthermore, the organic synthesis method of primary amides according to the present invention can be widely applied to the synthesis of pharmaceutical intermediates, natural products, and low-molecular-weight new drug candidate compounds.

A low-carbon and environment-friendly method for synthesizing a primary amine from a halogenated hydrocarbon in the technical field of organic synthesis is provided. The method includes adding formaldehyde and ammonia in an alcohol solution at a ratio of 8 mol:8 mol for a full reaction, then adding 3 mol of the halogenated hydrocarbon at a suitable temperature, followed by a full reaction, and performing a series of post-treatment steps to obtain a target primary amine product with relatively high purity.

The invention relates to a quinoxaline derivative containing trimethyl and n-propyl as well as a preparation method and application of the quinoxaline derivative, and the derivative is 1, 6, 7-trimethyl-3-propyl quinoxaline-2 (1H)-ketone and is particularly suitable for inhibiting fusarium oxysporum. The derivative is prepared by an organic synthesis method which comprises the step of carrying out cyclization reaction on N-protected o-phenylenediamine and a carbonyl compound in the presence of trifluoroacetic acid. Experiments show that the compound has a remarkable antibacterial effect on fusarium oxysporum, and the minimum inhibitory concentration is 0.50 mg / mL. The derivatives can destroy the cell membrane structure of fusarium oxysporum and cause leakage of RNA, protein and reducing sugar in cells, so that the growth of thalli is inhibited. The invention provides a theoretical basis and an experimental basis for developing a novel efficient and low-toxicity bacteriostatic agent.

The application belongs to the technical field of organic synthesis and relates to an organic synthesis method for benzyl protection of a hydroxyl group. The application provides an organic synthesis method for benzyl protection of a hydroxyl group, which comprises the following steps: dissolving benzyl chloride and KI in DMF, adding NaH, and then adding a DMF solution containing a substrate drop by drop to perform a temperature control reaction. The application provides a new idea for protection of a non-conventional hydroxyl group.

This invention discloses a method for preparing a seawater desalination evaporator based on an organic three-dimensional light-trapping and biomimetic suspension protection mechanism, including a. a synthesis route of small molecule photothermal materials; and b. a preparation process of the seawater desalination evaporator. This method for preparing a seawater desalination evaporator based on an organic three-dimensional light-trapping and biomimetic suspension protection mechanism uses low-cost wood pulp sponge as a matrix. The material is synthesized through a simple one-step organic synthesis method, dissolved in an organic solvent, and drop-coated onto the matrix to prepare a seawater desalination evaporator with a three-dimensional light-trapping and suspension protection mechanism. The evaporator preparation method provided by this invention enables more convenient, lower-cost, and higher-efficiency seawater desalination. The one-step high-yield organic synthesis method reduces the preparation cost of the evaporator.

The application belongs to the technical field of organic synthesis, and discloses a method for preparing n-butyl ether and butyl phenyl ether simultaneously through etherification reaction. Phenol, n-butanol and a phosphoric acid catalyst are mixed, and then etherification reaction is carried out under a protective gas to obtain n-butyl ether and butyl phenyl ether. The method can prepare n-butyl ether and butyl phenyl ether simultaneously, the combined selectivity of n-butyl ether and butyl phenyl ether can reach 98-99%, the reaction has few by-products, the conversion efficiency of raw materials is high, the products obtained by the reaction are important chemical raw materials, and the method has high economic benefits. The preparation method does not need to add strong acid and strong base, the reaction condition is mild, the safety coefficient of the preparation process is high, there is no defect of damage and corrosion to the equipment, and the method belongs to a more green and environmental protection organic synthesis method.

The invention relates to the field of organic synthesis methodology, in particular to a quinazoline dihydroimidazole thione derivative and a preparation method and application thereof.The quinazoline dihydroimidazole thione derivative is prepared by reacting aryl glyoxal, o-aminobenzene amine, aryl isothiocyanate and an additive at a certain temperature under the closed condition and the solvent condition. The method has the characteristics that the catalyst is cheap and easy to obtain, the raw materials are easy to obtain, the operation is simple, the reaction time is short, the yield is relatively high, the functional group compatibility of the substrate is good, a series of quinazoline and dihydroimidazole thione derivatives can be synthesized, and the method has a good potential application value.

The invention relates to the technical field of organic synthesis methodology, in particular to a high-throughput screening method for polypeptide compound peptide bond construction, which comprises the following steps: step 1, using a 24-pore plate as an experimental carrier, constructing 6 * 4 reaction systems according to 6 condensation reagents and 4 solvents, the solvent corresponds to the solvent of the solution A and the solvent of the solution B; 2, adding the solution A containing the carboxyl substrate, a condensation reagent and organic alkali into the reaction container, and reacting at 10-40 DEG C for 0.5-4 hours; and 3, adding a solution B containing an amino substrate into the reaction container, and carrying out a stirring reaction at 0-100 DEG C for 10-30 h to obtain the polypeptide compound as shown in the formula I. According to the method, the application of a high-throughput screening method in the field of organic chemistry is enriched, the optimal reaction reagent for constructing the peptide bond of the target compound can be quickly determined in a short time, and the efficiency and purity of synthesizing the peptide bond are greatly improved.

The application discloses a kind of di (propyl-2-alkenyl) furan-2, 5-dicarboxylic acid ester and preparation method thereof, it is related to biomass-based organic synthesis method technical field.The method with 2, 5-furan dicarboxylic acid as base material, by esterification reaction under the action of inorganic metal catalyst, will be grafted in 2, 5-furan dicarboxylic acid on allyl, obtains di (propyl-2-alkenyl) furan-2, 5-dicarboxylic acid ester.Compared with traditional synthesis method, the required reaction condition is relatively mild, without high temperature and high pressure environment, not only reduce energy consumption, also reduce operating risk and equipment cost.Mild reaction condition is also more conducive to keeping the activity and selectivity of catalyst, improves reaction efficiency.The obtained product is high in purity, without complex post-processing step can be directly used in subsequent application or further chemical conversion, improves overall production efficiency.The application provides a new idea for 2, 5-furan dicarboxylic acid and other biomass materials to realize high value-added utilization.

The application discloses an environment-friendly synthesis method of 28-homobrassinolide, wherein (2,22)-diene-24S-ethyl-5alpha-cholesta-6-ketone P1 is used as a starting material, double bonds on a ring of P1 are simultaneously epoxidized, namely, double epoxidation, ring opening, acetylation, one-time hydrolysis and two-time hydrolysis are carried out to obtain a tetrahydroxy compound, and finally, lactonization is carried out to obtain the target 28-homobrassinolide. The 28-homobrassinolide is synthesized by a brand-new organic synthesis method, which is energy-saving, efficient, environment-friendly, simple in process and good in industrial application value.

The invention discloses a device and a method for chemical organic wastewater treatment and carbon dioxide synergistic conversion. The device comprises an advanced oxidation reaction tank, a gas purification and collection system and a carbon dioxide conversion system which are connected in sequence, the advanced oxidation reaction tank is used for degrading organic matters in the chemical organic wastewater to generate carbon dioxide; the gas purification and collection system is used for removing impurities in the carbon dioxide gas and collecting purified carbon dioxide; the carbon dioxide conversion system converts carbon dioxide through an organic synthesis method. Aiming at the problem that a large amount of carbon dioxide is directly or indirectly discharged in the traditional chemical organic wastewater treatment process, the invention provides a method for degrading and mineralizing organic matters through advanced oxidation, and converting the generated carbon dioxide into chemicals with high added value through an organic chemical synthesis method, so that the synchronous pollution reduction and carbon reduction are realized.

The present application relates to the field of organic synthesis methodology, in particular to a kind of iron-mediated preparation method of hydrogenation alkylation of azauracil under light condition.The method first applies ligand-metal charge transfer (LMCT) mechanism to the hydrogenation alkylation reaction of uracil, uses cheap and easily available abundance metal iron as catalyst, uses alkane as alkylation raw material without pre-functionalization, reaction condition is mild, functional group tolerance is good, product yield can reach 75%~94%, suitable for late modification of drug molecules and bioactive molecules.

The present application relates to the technical field of organic synthesis, and particularly relates to a method for preparing 2-methylbenzoisothiazolin-3-ketone at room temperature by NCS participation. In the prior art, 2-methylbenzoisothiazolin-3-ketone is obtained by an organic synthesis method, the reaction condition is relatively harsh, the steps are relatively complicated, and the production efficiency is low. In view of the above technical problems, the present application provides a method for preparing 2-methylbenzoisothiazolin-3-ketone at room temperature by N-chlorosuccinimide (NCS) participation. NCS is used as a key additive, and 2-methylbenzoisothiazolin-3-ketone is successfully prepared by reacting 2-methylbenzoisothiazolin-3-ketone with 2-methylbenzoisothiazolin-3-ketone in a solvent at room temperature under the condition of severe stirring. The synthesis method of the present application is more efficient, the reaction condition is more mild, and has a good application prospect.

This invention discloses an asymmetric method for synthesizing fluorine-containing chiral quaternary carbon compounds, relating to the field of organic synthesis techniques. The method includes: using a carboxylic acid compound of Formula 1 and isopropanol as starting materials, and under the action of a catalyst, activating reagent, and base, with a fluorinated reagent as the fluorine source, reacting in an organic solvent to obtain an α-fluoro-α-substituted isopropyl carboxylate as shown in Formula 2. Using a carboxylic acid compound and isopropanol as starting materials, and under the action of a specific catalyst, activating reagent, and base, with a fluorinated reagent as the fluorine source, a specific reaction route is used to achieve highly enantioselective construction of α-fluoro-α-substituted carboxylic acid ester structures. This method has advantages such as mild reaction conditions, simple operation steps, and a wide range of applicable substrates, providing a new and effective approach for enriching the methods for constructing fluorine-containing chiral quaternary carbon compounds.

The invention relates to a cyclohexyl-containing quinoxaline derivative as well as a preparation method and application thereof, and the cyclohexyl-containing quinoxaline derivative is 3-cyclohexyl-1-methylquinoxaline-2 (1H)-ketone and is particularly suitable for inhibiting fusarium oxysporum. The derivative is prepared by an organic synthesis method which comprises the step of carrying out cyclization reaction on N-protected o-phenylenediamine and a carbonyl compound in the presence of trifluoroacetic acid. Experiments show that the compound has a remarkable antibacterial effect on fusarium oxysporum, and the minimum inhibitory concentration is 0.50 mg / mL. The derivatives can destroy the cell membrane structure of fusarium oxysporum and cause leakage of RNA, protein and reducing sugar in cells, so that the growth of thalli is inhibited. The invention provides a theoretical basis and an experimental basis for developing a novel efficient and low-toxicity bacteriostatic agent.