198 results about "Organic Synthesis Methods" patented technology

A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

The present invention relates to nanoparticles comprising a biodegradable polymer, preferably the vinyl methyl ether and maleic anhydride (PVM / MA) copolymer, and a polyethylene glycol or derivatives thereof. These nanoparticles are easy to produce and provide excellent bioadhesion, size and zeta potential characteristics making them suitable for the administration of active molecules. The selection of the type of polyethylene glycol used in their production allows suitably modulating the characteristics of these nanoparticles, which can be advantageously used according to the type of drug to be carried and / or the method of administration of the pharmaceutical formulation. pegylation is carried out by simple incubation for a short time period of the two macromolecules in question, without needing to have to resort to the use of organic solvents with high toxicity or long and laborious organic synthesis processes. Furthermore, the pegylation process can be associated to the process of encapsulating the biologically active molecule.

The invention relates to an organic synthesis method, in particular to a method for synthesizing an Arbekacin and an intermediate dibekacin thereof. The method comprises the following steps of: takinga kanamycin B as initial raw material, carrying out the following processes of aldol condensation, sulfonylation, sodium iodide replacement and elimination to form double bond, de-protection under acidic condition, amino-electron reduction and final hydrogenation, thus obtaining the dibekacin; taking 3',4'-dideoxy -3',4'-didehydro-kanamycin B as raw material, using a di-tert-butyl dicarbonate toselectively protect the amidogen of 3, 2', 6', 3'' sites; subsequently using the synthesized active ester to protect the 1-site amidogen; subsequently using tri-fluoroacetic acid to remove BOC; and carrying out hydrazinolysis and catalysis and hydrogenation of platinum oxide, thus obtaining the Arbekacin. The synthesis method has the advantages of simple operation, high outcome yield, reducing thecost of raw material, optimizing the reaction route, lowering the requirements to the reaction conditions and being beneficial to industrial production.

The invention discloses a method for preparing methanesulfonic acid by utilizing a bipolar membrane electrodialysis technology. The method comprises the following steps: treating a sodium methanesulfonate aqueous solution used as a raw material by virtue of a microporus filter; introducing the solution into a feed liquid chamber to perform bipolar membrane electrodialysis treatment; stopping operation when the conductivity of the feed liquid is reduced to be 2000mu s / cm or below, obtaining a methanesulfonic acid solution in an acid chamber, and recycling the alkaline solution in an alkaline chamber. In the bipolar membrane electrodialysis process, the membrane stack treatment is performed by adopting the two-compartment structure, three-compartment structure and four-compartment structure of bipolar membrane electrodialysis, and the yield of the methanesulfonic acid is effectively improved. According to the designed bipolar membrane four-compartment structure, introduction of sodium ions can be effectively blocked in the preparation process, and high-purity methanesulfonic acid is obtained. According to the method disclosed by the invention, the raw material cost is low, the alkali liquor is recycled, and the preparation cost is saved. Moreover, secondary environmental pollution in the traditional organic synthesis method is avoided, and the safety level is improved.

The invention belongs to the field of nonlinear optical materials, and particularly discloses a hydrogel-based solid-state up-conversion luminescence material and a preparation method thereof.The material can be directly used in atmospheric environment and has quite high stability.The method includes: under excitation of low-power-density green light (532 nm, 60 mW.cm-2), enabling up-conversion hydrogel on a PdTPP / DPA system to obtain blue up-conversion luminescence.When temperature is increased, up-conversion efficiency (phiUC)of the material is in positive correlation with temperature and is up to 12%.A convenient and quick idea is provided for preparing up-conversion luminescence materials, and deoxidization is not needed, so that instability in organic solvents, complexity of organic synthesis methods and unfavorable effect on ecological environment protection are avoided usually, and actual application value is increased greatly.The material has potential application value in photoelectrochemical hydrogen generation and in the fields of solar photovoltaic field, solar photocatalysis, environment photochemical technology and temperature sensors.

The invention discloses a synthesizing method of alcaine landol, which comprises the following steps: adopting S(+)-epichlorohydrin to replace 3-chlorine 1, 2-propanediol as raw material; optimizing; condensing; esterifying; etherifying; obtaining 3-[4-(2S, 3-epoxy propoxy) phenyl] propanoic acid (2, 2-dimethyl-1, 3-dioxolane-4S) methyl ester; opening loop with carbonyl diimidazole to make N-(2-aminoethyl) morpholine formamide oxalate in the isopropanol solution; proceeding salt precipitation directly to obtain the product.

The invention discloses an oxidizability and reducibility conducting polymer flow anode with used for a flow battery. An oxidizability and reducibility conducting polymer or a conducting polymer and an inorganic substance composite material are dispersed in electrolyte solution to form electrolyte of the flow battery, the electrolyte and a three-dimensional mesh current-collection body commonly constitute an emulsus flow electroactive polymer anode, and anode flow passes an anode chamber in a flowing form in the charging and discharging processes and is used for forming a flow battery system. As the dimension of the conducting polymer and the dimension of the inorganic substance composite material of the conducting polymer are large, the battery can adopt a common porous diaphragm; in addition, the corrosion of a medium system of the electrolyte of the battery used for an electroactive material to a solid current collector is small, and therefore, the environmental pollution is small in the production and using processes; the conducting polymer is rich in source, so as to be prepared on a large scale by an organic synthesis method; and the cost of the flow battery can be greatly lowered.

The present invention discloses a preparation method of cobalt porphyrin on carbon oxidation-reduction catalyst. Said method includes the following several steps: firstly, fully drying carbon black, high-energy ball grinding, then using 30 wt% of H2O2 or 6M HNO3 to make pretreatment; adding porphyrin monomer, cobalt acetate and pretreated carbon black into glacial acetic acid, uniformly mixing them, then placing them into a microwave reactor with reflux condensing device, heating to make reaction to obtain catalyst precursor body, then under the protection of argon heat-treating said catalyst precursor body for 2-4hr at 500-1000deg.C so as to obtain the invented cobalt porphyrin on carbon oxidation-reduction agent.

The invention discloses a method for improving CO2 adsorption of an MOF (metal-organic framework) material and belongs to the technical field of preparation of inorganic-organic hybridization. The method specifically comprises steps as follows: various porous MOF materials are prepared through synthesis with specific methods, various o-diyne aromatic compound monomers are synthesized with organic synthesis methods, organic monomers enter pore channels of the MOF materials through soaking, through simple thermal initiated polymerization reactions, the organic monomers are subjected to polymerization reactions in the pore channels of the MOF materials, and the MOF composite material is obtained. The polymer produced with the method can divide the pore channels of the MOF materials into smaller pore chambers suitable for capture of CO2, so that the CO2 adsorption capacity and selectivity of the MOF materials are improved. The thermal initiated polymerization method is easy to operate, the processing and molding speed is high, the cost of raw materials is low, and the method has industrial advantages.

The invention discloses a norbornene derivative based homopolymer containing heterogeneous sugar units and a synthetic method of the homopolymer. With the adoption of a gradient organic synthesis method, an acetyl protected norbornene monomer NB-Man-Glu-OAc containing heterogeneous sugars is prepared by combining with a copper catalyzed azido-terminal alkyne [3+2] cycloaddition reaction (CuAAC), then a linear sugar-containing homopolymer with controllable molecular weight and narrower molecular weight distribution is obtained with ROMP (ring-opening metathesis polymerization), and the final homopolymer PNB-Man-Glu-OH containing the heterogeneous sugar units is obtained by deprotection. One simple and efficient path is provided for synthesis of sugar-containing polymers which contain the heterogeneous sugar units, and synthesis of the sugar-containing polymers has great guiding significance in studying special recognition mechanism for the sugar units and lectin and developing functional sugar-containing polymers with special biological diagnosis functions.

The invention discloses a method for preparing zaltoprofen. The method, which is simple in operation route, environmentally-friendly and suitable for industrial mass production, can realize industrialization. The zaltoprofen is a non-steroid anti-inflammatory medicament having effects of relieving inflammation, pain and heat.

Isolated metabolites of the cyclosporine analog ISA247 are disclosed, including in vitro methods for their preparation. The metabolites comprise a chemical modification of ISA247, wherein the modification is at least one reaction selected from the group consisting of hydroxylation, N-demethylation, diol formation, epoxide formation, and intramolecular cyclization phosphorylation, sulfation, glucuronide formation and glycosylation. Methods of preparation include semi-synthetic methods, wherein metabolites of ISA247 are produced from the microsomal extracts of animal liver cells, or from cultures using microorganisms, and completely synthetic methods, such as chemically modifying the parent compound or isolated metabolites using organic synthetic methods.

The invention belongs to the luminescent material technology field, and in particular relates to a prepararion method of blue-ray emitting organic-inorganic composite silicon-based material. Firstly, the invention uses the organic synthesis method to graft the organic molecule with Schiff base structure into inorganic silicon framework, and then uses the sol-gel method to obtain xerogel by conducting hydrolysis polycondensation reaction on the precursor of organosilicone; after further drying and aging, the ultraviolet and visibly inspired OLED used nano-blue-ray hybrid material, which has stable chemical and thermodynamic properties and has regular surface appearance, is produced. The method of the invention requires moderate experimental conditions, the composite silicon-based material of the invention can be produced in room temperature dispensing with high-temperature calcinations, the maneuverability is strong, and the reproducibility is well. The obtained product has stable quality, can control the sizes of the grains within nanometer range, and has regular appearance.

The present invention describes a method of organic synthesis for N-homocysteine thiolactonyl retinamide, a compound that has anticancer and antiatherogenic properties.

The invention relates the organic synthesis method, especially the preparing method of cyclopentane 1, 2- diimide. The method comprises the following steps: dissolving the cyclopentane 1, 2-diformamide in organic solvent, then it reacting with acid salt, and getting the cyclopentane 1, 2- diimide. The invention has the characters of modifying the technology and improving the productivity. The invention has the advantages of reducing the preparing time, raw material, cost and pollution.

The invention discloses a new preparation method of hydrochloride landiolol; the route has simple operation, environmental-protection, is suitable for organic synthesis method of the industrial mass production, and can realize industrialization. The hydrochloride landiolol is selective beat1 receptor blocker, mainly antagonizes the beat1 receptor existing in the heart, and improves tachycardia arrhythmia through inhibiting the increase of heart rate caused by catecholamine.

The invention discloses a preparation method of core-shell graphene quantum dot @ mesoporous silica nano-material. The material employs graphene quantum dots as a core and hollow mesoporous silica asa shell, the diameter of nanometer particle is 80-120nm, and fluorescence emission wavelength is 570-670nm. The GQDs prepared by an organic synthesis method are used as a core, hMSN is used as a shellfor preparing GQDs@hMSN. The water soluble GQDs prepared by an organic phase synthesis method, GQDs is directly used as a core, in order to prepare the graphene quantum dot @ mesoporous silica nanometer particles, and after chemical etching, a compound with GQDs optical performance, a hMSN hollow meso-structure and abundant surface charges is prepared. The material has excellent optical properties and a hollow meso-structure, and the material can be applied to optical imaging and medical treatment in organism or diagnosis and treatment of tumor.

The invention belongs to the technical field of a luminescent high molecular material, in particular relates to a method for preparing luminescent rare earth-Beta-diketone-polyvinyl pyridine polymer macromolecule composite material. The organic synthesis method is adopted for modifying Beta-diketone organic small molecules so that the Beta-diketone organic small molecules become bridging molecules connecting an inorganic silica network and an organic polymer; subsequently, polyvinyl pyridine is synthesized through addition polymerization; the bridge molecule, the polymer and rare earth ions are assembled into a rare earth complex through coordination links; finally, adopting the sol-gel method, the rare earth complex is undergone the hydrolytie polycondensation of the bridging molecule to obtain xerogel; organic polymer macromolecules with long carbochains are inlaid in an inorganic silica network substrate; the polymer macromolecule composite material with stable chemical and thermodynamic property, regular surface topography and characteristic fluorescence emmission is got through drying and ageing. The preparation method can be carried out directly at room temperature, which is very operable and reproducible. The product quality is stable; the grain size can be controlled within the scope of micrometer and nanometer. In addition, the surface topography is regular.

The invention belongs to the technical field of luminescent macromolecular composite material, and particularly relates to a method for preparing a sulfhydryl functional rare earth-macromolecular composite luminescent material. In the method, firstly, by adopting an organic synthesis method, aromatic organic micro molecules are grafted in an inorganic silica skeleton to obtain organic bridge precursor; the organic bridge precursor, polymers and rare earth ions are further combined to obtain the rare earth macromolecular material by chemical action; at last, by the sol-gel method, all obtained materials are subjected to polyreaction to obtain dried gel, so that the organic macromolecular polymers with long carbon chains are embedded in silica network substrate by covalent bond; and the dried gel is subjected to dry ageing to obtain the macromolecular composite material with stable chemical and thermodynamic performances, smooth surface appearance and special luminescence emission. The method has the advantages of simple preparation process, mild experimental conditions, strong operability, good reproductivity, low cost, stable quality of obtained products and order appearance, and the sizes of crystal grains can be controlled in the range of micron and nanometer.

The invention belongs to the technical field of an organic synthesis method, and particularly relates to a method for asymmetrically synthesizing a chiral quaternary carbon compound containing trifluoromethyl. The method comprises the following step: reacting trifluoromethyl nitroolefin with a 2-acetylaza aromatic compound to asymmetrically synthesize (R)-3- trifluoromethyl-3-nitryl methyl-1-(aza aromatic ring-2-yl)-butyl-1-acetone under the catalysis of bisoxazoline chiral ligand and a nickel catalyst in an organic solvent by adopting asymmetrically catalytic Michael addition reaction. The method is high in reaction yield and high in optical purity. The method disclosed by the invention can be used for a preparation tool for providing a trifluoromethyl quaternary carbon chiral compound.

The invention relates to a method for binding and fixing an ionic type iridium coordination compound based on a covalent bond, belonging to the field of electrochemiluminescence detection. The method comprises the following steps: firstly, preparing an ionic type iridium coordination compound hexafluorophosphoric acid di(6-methyl-2,4-(4'-methoxy)-diphenyl quinoline (4,4'-dicarboxyl-2,2'-dipyridyl) coordination iridium ((dpq-OCH3)2Ir(dcbpy)+PF6-) with carboxyl by adopting an organic synthesis method, respectively adding 1-ethyl-(3-dimethyl aminopropyl) carbonyl diimine (EDC) and N-hydroxyl succinimide (NHS) to activate the carboxyl, then, adding mercaptoethylamine to stir and react with the carboxyl; and then, preparing nanogold on the surface of a glassy carbon electrode by adopting an electrodeposition method, inserting a prepared electrode into the solution system, and forming an Au-S covalent bond through chemical reaction of the two, and loading the ionic type iridium coordination compound on the electrode. An electrochemiluminescence solid-phase electrode prepared by the method has good response for coreactant dibutyaminoethanol (DBAE).

The invention discloses a supermolecule heterojunction organic photocatalyst and a preparation method and an application method thereof. The photocatalyst is a BiOCl / PDI photocatalyst. Sheet shape BiOCl is prepared by a hydrothermal method; and perylene diimide (PDI) is synthesized by an organic synthesis method. BiOCl and PDI are taken as the raw materials to synthesize the BiOCl / PDI photocatalyst, or BiOCl and acidified PDI are taken as the raw materials to synthesize the BiOCl / PDI photocatalyst. The invention also provides an application method of using the photocatalyst to degrade organicmicro-pollutant wastewater. The preparation technology of the prepared BiOCl / PDI supermolecule photocatalyst is simple; the output is large; organic micro-pollutants in water can be efficiently degraded under a photocatalytic condition and a neutral condition without adding any oxidant; and the photocatalytic effect on cation type pollutants is better.

The invention relates to a chiral allyl ester compound and a preparation method thereof. The structural formula of the chiral allyl ester compound is represented in the description. The preparation method comprises the following steps: adding raw materials (carboxylate and allyl halide) into an organic solvent, then adding an iridium catalyst, which is prepared by reacting an iridium complex with a ligand, adding additives, controlling the reaction temperature in a range of 0 to 120 DEG C, carrying out reactions for 1 to 36 hours, and separating the reaction products so as to obtain the chiral allyl ester compound. In the prior art, when active allyl halide is taken as the substrate, the reaction yield is low and the enantioselectivity is bad, and the provided preparation method overcomes the problems mentioned above. Moreover the preparation method has the characteristics of high reaction yield, good region-selectivity, and high enantioselectivity, and thus is widely used in the organic synthesis methodology and natural product synthesis.

The invention belongs to the field of nonlinear optical materials and particularly discloses an efficient green dim light upconversion system based on a protic solvent. The sensitizer triplet state energy level can be improved simply and efficiently through proton media. Under the excitation of low power density green rays (532 nm, 60mW.cm<-2>), blue upconversion fluorescence is obtained in a PdTPP / DPA / propanol / ethylene glycol (v / v, 1 / 2) (a protic solvent) system, and the upconversion efficiency (phi UC) is as high as 29.1%. The convenient thinking is provided for improving triplet state-triplet state annihilation upconversion conversion, the solvent micro-environment effect is utilized, and thus the complexity of an ordinary organic synthesis method and the disadvantage for ecological environmental protection are avoided. The efficient green dim light upconversion system can be used for photoelecrochemical hydrogen production and has potential application values in the techical fields such as photovoltaics, solar photocatalysis and environmental photochemistry.

The invention relates to an organic synthesizing method of traditional Chinese medicinal herbs, microbes and inorganic micro elements, in particular to a preparing method of solid fermentation for a traditional Chinese medicinal herb yeast selenium. Inorganic selenium, auxiliary material of traditional Chinese medicinal herbs and common main materials are added when culturing yeasts, by absorption and transformation of selenium, herbs and main materials in the growth of the yeasts, traditional Chinese medicinal herb yeast selenium that is rich with nutritious and health-caring elements necessary for growth and health caring of animals is generated under special environment and condition. Comparing with the transformation of inorganic into organic selenium and prior method for extracting and purifying effective components in traditional Chinese medicinal herbs by industrial way, the invention is of high transformation rate; the equipment is simple, easy to operate, is of low cost and useful for production and collecting in large scale.

The invention relates to stable isotope labeled sudan red I and its synthesis method. The invention makes use of an organic synthesis method which comprises: employing stable isotope labeled benzene as a raw material, conducting nitration reaction so as to generate stable isotope labeled nitrobenzene, which then reacts with a reducing agent so as to obtain stable isotope labeled aniline, which is then subjected to diazotization as well as coupling with naphthol, thus obtaining stable isotope labeled sudan red I. Compared with prior art, the stable isotope labeled sudan red I prepared by the invention has chemical purity up to more than 98% and isotopic abundance over 98% after separation and purification, thus fully satisfying the demand for prohibited dye detection in the food safety field.

The invention relates to a stable isotope labeled benzyl butyl phthalate and a synthesis method thereof. According to the invention, an organic synthesis method is adopted; stable isotope labeled phthalic anhydride is adopted as a raw material, and is subjected to a reaction with benzyl alcohol, such that stable isotope labeled monobenzyl phthalate is produced; the stable isotope labeled monobenzyl phthalate is subjected to a reaction with butanol, such that stable isotope labeled benzyl butyl phthalate is obtained. Compared with the prior art, when the stable isotope labeled benzyl butyl phthalate is separated and purified, a chemical purity can be higher than 99%, and an isotope abundance is higher than 99%, such that the demand of the detection of the illegal additive benzyl butyl phthalate in the field of food safety can be fully satisfied.

The invention discloses a pyrrolidine derivative and a preparation method thereof. The structural general formula of the pyrrolidine derivative is as shown in formula I. The invention provides a high-efficient organic synthesis method for realizing direct intramolecular ammoniation reaction of a straight-chain amine compound with the help of a transition metal catalytic system. The method has the advantages of simple and convenient process, high product yield, mild reaction conditions, wide range of application of substrates and good compatibility of a functional group, realizes intramolecular ammoniation reaction taking amino alcohol and amine substrates as main bodies, and further has important application values.

Isolated metabolites of the cyclosporine analog ISA247 are disclosed, including in vitro methods for their preparation. The metabolites comprise a chemical modification of ISA247, wherein the modification is at least one reaction selected from the group consisting of hydroxylation, N-demethylation, diol formation, epoxide formation, and intramolecular cyclization phosphorylation, sulfation, glucuronide formation and glycosylation. Methods of preparation include semi-synthetic methods, wherein metabolites of ISA247 are produced from the microsomal extracts of animal liver cells, or from cultures using microorganisms, and completely synthetic methods, such as chemically modifying the parent compound or isolated metabolites using organic synthetic methods.