Solid-state fermentation preparing method for Chinese herbal medicine yeast selenium

A solid-state fermentation, Chinese herbal medicine technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of low conversion rate, high cost, loss of active ingredients, etc., and achieve easy operation, high conversion rate, Equipment simple effect

Inactive Publication Date: 2008-03-12
梁林
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in animal feed and feed additives, selenium supplementation is divided into inorganic selenium and organic selenium. Inorganic selenium is generally selenate, but selenate is highly toxic, and improper use will cause serious adverse consequences. Organic selenium Selenium has the advantages of high absorption rate, strong biological activity, low toxicity and less environmental pollution, but the conversion of inorganic selenium to organic selenium is mainly completed by animal or plant organisms, with low conversion rate, high cost and small production volume
[0004] At the same time, most of the Chinese herbal medicine products currently used for animal health care are monomer mixtures extracted and purified from Chinese herbal medicines. Many active ingredients of Chinese herbal medicine are lost during the purification process, and the cost of extraction and purification is very high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The main material composed of soybean meal and wheat bran is uniformly mixed in a weight ratio of 7:2, and the weight composition of each component in the Chinese herbal medicine auxiliary material is 10% of epimedium, 10% of astragalus, 10% of Huangling, and 10% of Radix Radix , Andrographis paniculata 10%, Prunella vulgaris 10%, Phellodendron 10%, Honeysuckle 10%, Sophora flavescens 5%, Qinpi 5%, Notopterygium 5% and Coptidis 5%, then the wort juice and sodium selenite were mixed to make a culture solution, The concentration of selenium in the culture solution is 33.3g / kg, and the weight proportions of main ingredients, Chinese herbal medicine auxiliary materials and culture solution are 55%, 30% and 15% respectively. After inoculation and fermentation, yeast selenium is obtained, wherein the selenium The content is 2000mg / kg.

Embodiment 2

[0032] The main material composed of soybean meal and bran is uniformly mixed in a weight ratio of 7:5, and the weight composition of each component in the Chinese herbal medicine auxiliary material is 15% of Epimedium, 15% of Radix Astragali, 10% of Huangling, and 15% of Radix Radix %, Andrographis paniculata 3%, Prunella vulgaris 5%, Phellodendron 4%, Honeysuckle 5%, Sophora flavescens 6%, Qinpi 8%, Notopterygium 8% and Coptidis 6%, and then the wort juice and sodium selenite were mixed to make a culture solution , the concentration of selenium in the culture solution is 8.3g / kg, and the weight proportions of main ingredients, Chinese herbal medicine auxiliary materials and culture solution are 85%, 10% and 5% respectively, after inoculation and fermentation, yeast selenium is obtained, wherein The content of selenium is 500mg / kg.

Embodiment 3

[0034] The main material composed of soybean meal and wheat bran is mixed evenly in a weight ratio of 7:3, and the weight composition of each component in the Chinese herbal medicine auxiliary material is 8% of Epimedium, 12% of Radix Astragali, 8% of Huangling, and 12% of Radix Radix , Andrographis paniculata 10%, Prunella vulgaris 8%, Phellodendron 10%, Honeysuckle 8%, Sophora flavescens 6%, Qinpi 8%, Notopterygium 6% and Coptis 4%, and then the wort juice and sodium selenite were mixed to make a culture solution, The concentration of selenium in the culture solution is 25g / kg, and the weight proportions of main ingredients, Chinese herbal medicine auxiliary materials and culture solution are 80%, 10% and 10% respectively. After inoculation and fermentation, yeast selenium is obtained, wherein the The content is 1184mg / kg.

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Abstract

The invention relates to an organic synthesizing method of traditional Chinese medicinal herbs, microbes and inorganic micro elements, in particular to a preparing method of solid fermentation for a traditional Chinese medicinal herb yeast selenium. Inorganic selenium, auxiliary material of traditional Chinese medicinal herbs and common main materials are added when culturing yeasts, by absorption and transformation of selenium, herbs and main materials in the growth of the yeasts, traditional Chinese medicinal herb yeast selenium that is rich with nutritious and health-caring elements necessary for growth and health caring of animals is generated under special environment and condition. Comparing with the transformation of inorganic into organic selenium and prior method for extracting and purifying effective components in traditional Chinese medicinal herbs by industrial way, the invention is of high transformation rate; the equipment is simple, easy to operate, is of low cost and useful for production and collecting in large scale.

Description

technical field [0001] The invention relates to an organic synthesis method of Chinese herbal medicine, microorganisms and inorganic trace elements, in particular to a solid-state fermentation preparation method of Chinese herbal medicine yeast selenium. Background technique [0002] In animals, selenium is an essential component of glutathione peroxidase and 5-deiodinase, and is also a component of many proteins, which plays an important role in the anti-oxidation, anti-stress, and improvement of immunity in animals. It plays an important role, and about 2 / 3 of my country's areas are selenium-deficient areas, so selenium supplementation is of great significance in animal production in my country. [0003] At present, in animal feed and feed additives, selenium supplementation is divided into inorganic selenium and organic selenium. Inorganic selenium is generally selenate, but selenate is highly toxic, and improper use will cause serious adverse consequences. Organic seleniu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/16A61K36/064A61P3/02A61P37/04
Inventor 梁林
Owner 梁林
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