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Method for monitoring propofol narcotic in on-line manner

A technology of propofol and anesthetics, which is applied in the preparation of test samples, measuring devices, and material analysis through electromagnetic means, can solve the problems of inability to report actual concentrations, high requirements for external configuration, and difficult purchase channels, etc., and achieve The effect of fast measurement speed, high cost performance and simple measurement method

Inactive Publication Date: 2012-05-16
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the system can only detect the mass signal and not report the actual concentration
PTR-MS is currently the best method for determining the concentration of propofol in exhaled breath, but it is expensive, difficult to purchase, requires high external configuration, bulky, and poor portability
Magnetic fields generated during heating of transfer wires can seriously interfere with medical implements, affecting patient safety

Method used

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  • Method for monitoring propofol narcotic in on-line manner
  • Method for monitoring propofol narcotic in on-line manner
  • Method for monitoring propofol narcotic in on-line manner

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 1-100 μL of headspace vapor from the upper end of the propofol anesthesia vial with a syringe. In the negative ion mode, the ion mobility spectrometer is used as the detection instrument. The carrier gas carries the propofol anesthetic sample into the ionization region of the ion mobility spectrometer. The flow rate of the carrier gas is 800 sccm; the sample is ionized into positive and negative ions in the ionization region. The opened ion gate enters the drift region formed by a uniform electric field, and is separated and detected in the drift region.

[0032] figure 2 The ion mobility spectrum of the negative ion mode ion mobility spectrometer detection background is given, and the negative ion mode reagent ion peak (RIP) appears at about 6.5ms. figure 2 In order to change the ordinate of the software, zoom in and observe the ion mobility spectrum of the monitoring signal.

Embodiment 2

[0034]According to the vapor pressure of propofol anesthetic at 20°C is 0.142mmHg. The concentration of its saturated vapor can be calculated. Between 0.1-200μL, several samples of propofol with different concentrations are taken, injected into a 500mL glass reagent bottle for dilution, and the final concentration is calculated and determined. Record the peak of propofol anesthetics with different concentrations.

[0035] Fig. 3 has provided the ion mobility spectrogram that detects different amounts of propofol anesthetics with negative ion mode ion mobility spectrometer, as can be seen from the figure, reagent ion peak (RIP) occurs at about 5.4ms, as shown in Figure 3 ( a) As shown in 0.1μL saturated propofol vapor, the peak time is 8.4ms; as shown in Figure 3(b), the peak time of 0.5μL saturated propofol vapor is 8.4ms, and the signal intensity is enhanced; as shown in Figure 3(c) The 1 μL saturated propofol vapor shown has two signal peaks, and the peak time is 8.4ms and ...

Embodiment 3

[0037] In the negative ion mode, the ion mobility spectrometer is used as the detection instrument, and a three-way valve is connected to the carrier gas inlet gas path. Open the above-mentioned vial containing 1 mL of propofol anesthetic drug, and gently approach and take a breath. Then blow air through one end of the tee, and the sample gas is brought into the ionization region of the ion mobility spectrometer by the carrier gas. The flow rate of the carrier gas is about 800 sccm; The drift region formed by the electric field is separated and detected in the drift region. Different compounds have different mobility constants, move at different speeds in the drift region, and take different times to reach the detector. By measuring the time of ion arrival at the detector and the peak intensity, the compound can be identified and its amount is measured based on the signal intensity of the peak.

[0038] Figure 4 Shown is the negative ion mode ion mobility spectrometry dire...

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Abstract

The invention discloses a method for monitoring traced propofol narcotic rapidly and sensitively. In the method, an ion mobility spectrometry technology is taken as a basic detection technology, and an anion mode is adopted to establish a method for monitoring traced propofol narcotic. The method comprises the following steps: feeding a gas sample containing propofol into an ion mobility spectrometry tester for analysis to obtain a detecting signal, and then carrying out qualitation and quantitation. According to the invention, the measurement of a narcotic sample can be detected in real time, and the limit of detection of the propofol narcotic can reach 0.5ppb. The detecting method is simple, convenient, rapid and efficient and is good in reliability.

Description

technical field [0001] The invention relates to an on-line monitoring method of propofol anesthetic, in particular to a new fast, sensitive and real-time on-line monitoring method of propofol anesthetic. The method is based on the ion mobility spectrometry technique, and the rapid anesthetic drug monitor is used as an analysis method, and the detection limit of propofol anesthetic drug can reach 0.5ppb. The instrument is small in size, short in analysis time, and can perform qualitative and quantitative analysis. The measurement method is simple, fast, efficient and reliable. The method has fast analysis speed, simple test operation, no complicated sample pretreatment experiment, and no special professional background personnel to operate. Background technique [0002] Propofol, whose chemical name is 2,6-diisopropylphenol, is a new type of rapid and short-acting intravenous anesthetic commonly used clinically for induction of anesthesia, maintenance of anesthesia, and sed...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N1/28G01N15/06G01N27/622
Inventor 李海洋王新李京华李林
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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