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Accurate method for detecting propofol anesthetic in blood

An anesthetic and propofol technology is applied in the precise field for detecting propofol anesthetic in blood, which can solve problems such as difficult drug use and precision, and achieve the effects of less consumables, simple measurement method, and accurate quantitative analysis.

Inactive Publication Date: 2014-06-25
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the judgment of the depth of anesthesia in clinical medicine only depends on years of experience in drug use, and it is difficult to accurately use the drug due to the influence of human body differences.

Method used

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  • Accurate method for detecting propofol anesthetic in blood
  • Accurate method for detecting propofol anesthetic in blood
  • Accurate method for detecting propofol anesthetic in blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The propofol anesthetic sample obtained an ideal detection signal in the negative ion mode. The ion mobility spectrometer used in the experiment was under the experimental operating conditions, and the air reagent ion peak appeared at about 5ms (such as figure 2 ).

Embodiment 2

[0033] Take a blood sample of 1-50 μL with a micro-sampler at the sampling place of the sampling chip. In the negative ion mode, ion mobility spectrometry detects blood samples for analysis, and the endogenous substances in the blank plasma do not interfere with the detection of propofol, such as image 3 shown. Propofol standard peak migration time is 8.3ms, and the background signal of blood blank is about 45mv on average at 8.3ms.

Embodiment 3

[0035] Qualitative analysis test: Take 10 μL of blood sample solutions containing 1ppm, 5ppm, 10ppm, and 20ppm propofol anesthesia with a micro-sampler, respectively, at the sampling place of the sampling piece. Under the experimental operating conditions of the ion mobility spectrometer used, the peak-to-peak migration time of the propofol anesthetic sample signal peak is about 8.3ms. Using the method of the present invention to analyze the summed average signal (without deducting the background signal) is 100mv, 325mv, 526mv, 1120mv (such as Figure 4-7 shown).

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Abstract

The invention discloses a rapid sensitive method for detecting a propofol anesthetic in blood. By adopting the ion-mobility spectrometry technology as a basic detection technology and adopting an anion mode, a rapid qualitative and quantitative analysis method for detecting the propofol anesthetic in the blood by ion-mobility spectrometry is established. The limit of detection can reach smaller than 1 ng (a concentration smaller than 0.1 ppm). The range of quantitative analysis concentrations is 0.5-20 ppm, thus meeting the human blood dose concentration analysis range. The analysis time of each sample is shorter than 30 s. No pretreatment technology is needed. The method is simple, rapid, efficient and high in reliability, and can be widely used for clinical-administration deep analysis and used for guiding the medication by a doctor.

Description

technical field [0001] The invention discloses a precise detection method for propofol anesthetic in blood, which uses ion mobility spectrometry technology as the basic detection technology, adopts negative ion mode, and establishes ion mobility spectrometry to quickly detect the qualitative and quantitative analysis of propofol anesthetic in blood method. The measurement method is simple, fast, efficient and reliable, and can be widely used in the concentration analysis of medical clinical administration and guide doctors in clinical administration. Background technique [0002] Blood is an opaque red liquid that flows in the heart and blood vessels, and its main components are plasma and blood cells. Belongs to connective tissue, the layer of structure in living systems. Blood contains various nutrients, such as inorganic salts, oxygen, and cell metabolites, hormones, enzymes, and antibodies, which have the functions of nourishing tissues, regulating organ activities, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/64G01N27/68
Inventor 王新李海洋鞠帮玉李杭渠团帅
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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