Continuous chemical reaction system and method for arylboronic acid ester synthesis through micro-fluidic chip under flowing

Abstract

The invention discloses a flowing chemical reaction system for preparing diazonium salt and synthesizing arylboronic acid ester through a micro-fluidic chip at room temperature as required under flowing. The system comprises a micro-fluidic chip diazonium salt preparation reaction module, a micro-fluidic chip arylboronic acid ester synthesis module and an online monitoring module; the micro-fluidic chip diazonium salt preparation reaction module comprises a sample bottle, a high-performance liquid phase infusion pump, a 3D mixed chip, a temperature-controllable reaction chip, a constant-temperature circulating water bath device and a fluid switching valve; the micro-fluidic chip arylboronic acid ester synthesis module comprises a sample bottle, a high-performance liquid phase infusion pump, a 3D mixed chip, a temperature-controllable reaction chip, a constant-temperature circulating water bath device and a fluid switching valve; and the online monitoring module comprises a nuclear magnetic spectrometer and a computer. The invention also discloses a method for preparing arylboronic acid ester based on the system and an application of the arylboronic acid ester.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis and on-line monitoring using a microfluidic chip in flow chemistry, and specifically relates to a method of preparing diazonium salt and performing arylboronic acid on demand at room temperature through a microfluidic chip under flow. Flow chemical reaction systems and methods for ester synthesis. Background technique [0002] In recent years, the use of microfluidic chips for organic synthesis in flow chemistry has attracted great attention from chemists. The emergence of this emerging technology can not only scale up small laboratory flask reactions to industrial scale, but also use flow chemistry It can realize 24-hour continuous production and prepare on demand, which overcomes the inherent limitations of traditional batch reactions. The microfluidic chip is also known as the laboratory on a chip. Due to its excellent mass transfer efficiency, efficient heat transfer, mixing effect ...

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Problems solved by technology

The limitations of these methods are: nucleophilic substitution of trialkyl borates is limited by their low functional group compatibility; use of transition metals leads to poor product quality, high cost and generation of toxic waste; large-scale production of diazonium salts When, its poor stability will lead to runaway reaction and cause risk

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