302 results about "Impedance analyzer" patented technology

The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.

A system for measuring parameters in a container is disclosed. A system for measuring multiple parameters includes a container having a solution, at least one sensor in conjunction with a tag is in proximity to an impedance analyzer and a reader that constitute a measurement device. The at least one sensor is configured to determine at least one parameter of the solution. The tag is configured to provide a digital ID associated with the sensor, where the container is in proximity to the reader and an impedance analyzer. The impedance analyzer is configured to send and receive a given range of frequencies from the sensor, based on the parameter and calculate parameter changes based on the response.

A method and system for real-time continuous impedance monitoring along the surface of a graft implanted within a main vessel to aid in optimally positioning an electrode at a branch vessel ostium. Due to the conductivity differences among various kinds of solid tissue and blood, a fenestration catheter system uses impedance monitoring as a tool to detect the location of branch ostia through graft cloth. Such information enables the fenestration electrode to be properly positioned for creation of a fenestration in the graft cloth in situ. In addition, the fenestration catheter system may utilize impedance information to avoid contact between the electrode and metal stent structures used to anchor the graft during an in situ fenestration procedure. The fenestration catheter system includes a catheter shaft, an electrode, one or more reference or indifferent electrodes, an impedance analyzer, a power source and an electrode position reference to record impedance measurements in relation to position.

The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cell-substrate monitoring systems comprising one or more cell-substrate monitoring devices comprising multiple wells each having an electrode array, an impedance analyzer, a device station that connects arrays of individual wells to the impedance analyzer, and software for controlling the device station and impedance analyzer. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays. In other preferred aspects, the assays are designed to investigate the compounds that effect IgE-mediated responses of cells to antigens.

An impedance analyzer is provided. The analyzer includes a signal excitation generator comprising a digital to analog converter, where a transfer function of the digital to analog converter from digital to analog is programmable. The impedance analyzer further includes a receiver comprising a low noise amplifier (LNA) and an analog to digital converter (ADC), where the LNA is a current to voltage converter; where the programmable digital to analog transfer function is implemented by a direct digital synthesizer (DDS) and a voltage mode digital to analog converter, or a digital phase locked loop (PLL), or both. Further, a multivariable sensor node having an impedance analyzer is provided. Furthermore, a multivariable sensor network having a plurality of multivariable sensor nodes is provided.

A system for measuring parameters in a container is disclosed. A container has a solution. A protective layer is deposited over at least one sensor and at least one wall of the container, where the protective layer is attached to the wall of the container to form a seal between the container and the at least one sensor. The at least one sensor is configured to have an operable electromagnetic field based on a thickness of the container and the protective layer. The at least one sensor in conjunction with a tag is in proximity to an impedance analyzer and a reader that constitute a measurement device. The at least one sensor is configured to determine at least one parameter of the solution. The tag is configured to provide a digital ID associated with the at least one sensor, where the container is in proximity to the reader and an impedance analyzer. The impedance analyzer is configured to receive a given range of frequencies from the at least one sensor based on the measured complex impedance over the given range of frequencies.

A method for multivariable measurements using a single-chip impedance analyzer includes providing a sensor, exposing the sensor to an environmental parameter, determining a complex impedance of the sensor over a measured spectral frequency range of the sensor, and monitoring at least three spectral parameters of the sensor.

The present invention relates to a microchip using polyelectrolyte salt bridge for cytometry, velocimetry, and cell sorting. The microchip comprises; a) an inlet for solution to be analyzed, b) a microchannel which provides a moving passage for solution to be analyzed, c) at least one outlet for solution to be analyzed which has passed through the moving passage, d) at least one electrode system comprising a first and a second salt bridges connected to the microchannel (the two salt bridges face each other), and a first and a second reservoirs connected to said each salt bridge (the reservoir comprises electrode and standard electrolyte solution). The microchip detects analytes in the solution to be analyzed (for example, a cell) by detecting change of impedance. In detail, anion in the standard electrolyte solution, which is comprised in the first reservoir, moves from the first salt bridge to the second salt bridge across the microchannel. Impedance change occurs by interference of anion moving across the microchannel and the change can be detected by impedance analyzer connected to electrodes in the first and the second reservoirs.

A variable-frequency stimulator for electrosurgery includes an impedance analyzer to identify the electrical impedance of biological tissue being treated by an electrosurgical instrument, such as a laparoscope. Based on the identified tissue impedance, a controller adjusts the frequency of electrical current delivered to the electrosurgical instrument to reduce, minimize or normalize the impedance of the tissue, thereby preventing collateral damage to the tissue in and about the surgical site. Additionally, the laparoscope may be configured with multiple electrically conductive grasping arms that are used to deliver the electrical current to the surgical site. The conductive grasping arms provide multiple current paths for the electrical current to flow, thus concentrating the electrical current at the surgical site during an electrosurgical procedure. Thus, the unwanted spread of electrical current in the tissue is prevented, resulting in the reduction or prevention of collateral damage to tissue in and about the surgical site.

A wireless, integrated, mountable, portable, battery-operated, non-contact eddy current sensor that provides similar accuracy to 1970's laboratory scale equipment (e.g., a Hewlett-Packard GP4194A Impedance Analyzer) at a fraction of the size and cost.

The invention relates to a method for detecting tumour cells by adopting a microelectrode array impedance biosensor chip. The method comprises the steps of: adopting nanometer immunity magnetic microballoon concentration separating technology to capture tumour cells from sputamentum or blood samples to form magnetic miroballoon-tumour cell biological magnetic combination; and utilizing magnetic force generated by a magnet to lead the magnetic miroballoon-tumour cell biological magnetic combination to be instantly absorbed on the surface of the microelectrode array impedance biosensor chip, arousing principles of changing impedance characteristic of micro-sensing electrode and adopting an impedance analyzer to conduct parallel scanning testing to the impedance characteristic of the micro-sensing electrode so as to determine whether the tumour cells exist. The invention provides a non-damage, quick, simple and convenient tumour cell detection method, and can be applied to the tumour early diagnosis and treatment, and can be used for diagnosing and monitoring the shifting and recurring of cancer cells of clinical tumour patients and carrying out wide prediction for major diseases, and also can be applied to the fields such as food detection, drug screening and the like.

The present invention is directed to a method and apparatus that satisfies the need for a bioelectronic tongue for food allergy detection. The method of detecting concentration of food allergen incorporates antibodies into an electronic tongue to create a bioelectronic tongue. Additionally the method uses impedance, capacitance, and / or other related electrochemical methods for detecting analyte in complex media. Furthermore the method additionally includes methods to subtract out non-specific interactions. The method also subtracts non-specific interactions. The device / apparatus is a Bioelectronic Tongue for detecting allergen in diluted food samples. The device includes: a sensor array; an impedance or capacitance analyzer; a preprocessor; a feature extractor; a pattern recognizer; and an output device indicating an allergen concentration. In order to implement the method of detecting food allergens on a bioelectronic tongue a computer readable medium containing an executable program is used for performing the analysis of a food sample. The executable program performs the acts of: preprocessing data from an impedance analyzer; extracting a feature pattern; recognizing a pattern of features of data representing a concentration of food allergen contained is the food sample; and outputs allergen concentration data.

An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer supported by the housing and operable to measure impedance of the starting material to detect the presence of a contaminant.

Coil is made to be disposed with gap opposed to the surface of wafer, and wafer stage is made to move in X and Y direction and R and θ direction. When supplying an alternating current to coil with the frequency swept by impedance analyzer, the magnetic field made to be induced in coil will operate on the conductive film of wafer. By changing a parameter (a frequency or an angle) influencing the skin effect of the conductive film and giving the parameter to coil, the state where a magnetic field is not made to penetrate relatively the film of wafer and the state where the magnetic field is made to penetrate relatively the film can be formed. From the variation of various values corresponding to the eddy current induced based on the change of state influenced by the skin effect of the conductive film, the film thickness of wafer can be measured with sufficient accuracy.

An electro-magnetic interference detecting system for power line conduction is provided. The electro-magnetic interference detecting system for the power line conduction comprises an electro-magnetic interference (EMI) receiver, a line impedance stabilization network (LISN), a current probe, a voltage probe, an impedance analysis meter and an oscilloscope, wherein the EMI receiver, the LISN, the current probe, the voltage probe, the impedance analysis meter and the oscilloscope are sequentially connected to form a system. The electro-magnetic interference detecting system for the power line conduction is simple and convenient and reliable in the detection process, and facilitates operation of technicians.

Systems and methods for improved monitoring of excitation-contraction coupling and excitable cells are provided, which provide millisecond time resolution. The system is capable of continuously monitoring excitation-contraction coupling in a relatively high-throughput manner. The system includes a device for monitoring cell-substrate impedance, an impedance analyzer capable of impedance measurements at millisecond time resolution, electronic circuitry that can engage the device and selectively connect two or more electrode arrays of the device to the impedance analyzer and a software program that controls the electronic circuitry and records and analyzes data obtained from the impedance analyzer.

A controller and infrastructure for an impedance analyzer measures responses to perturbations to respective phases of a multi-phase system at an interface between stages thereof (which may be considered as a source and load in regard to each other), such as a multi-phase electrical power system, to determine a transfer function for each phase of the multi-phase system from which the impedance of each of the source and load can be calculated, particularly for assessing the stability of the multi-phase system.

A method for multivariable measurements using a single-chip impedance analyzer includes providing a sensor, exposing the sensor to an environmental parameter, determining a complex impedance of the sensor over a measured spectral frequency range of the sensor, and monitoring at least three spectral parameters of the sensor.

The invention relates to a method for detecting bacteria by using the electrochemical impedance principle and a microfluidic chip. The method comprises the following steps of 1) arranging one microfluidic chip and determining the functional relation between the system impedance value and the bacterial concentration by using a standard; 2) filling bacteria samples to be detected in a sample inlet of the microfluidic chip and flushing to remove the redundant samples; 3) connecting an impedance analyzer with a conductive electrode in a microfluidic chip detecting zone, reading data displayed in the impedance analyzer and recording the measured impedance value of the bacteria sample; 4) calculating the number of the target bacteria in the bacteria sample according to the determined functionalrelation of the system impedance value and the bacterial concentration. The complex processing for the samples, particularly for the anaerobic bacteria samples, is unnecessary, the required equipmentis simple, the detection is quick, the cost is saved, the integration and miniaturization are easy, and the invention creates favorable conditions for realizing individualization of bacteria detection and real-time in vivo detection of the bacteria so as to better promote and maintain the human health.

The invention discloses a frequency conversion transmission system motor side common code impedance extraction method. Through measuring time domain waveforms of a common mode voltage and a common mode voltage of a frequency conversion transmission system motor side and through subsequent mathematical calculation, a frequency spectrum characteristic of a frequency conversion transmission system motor side common code impedance is acquired. Compared to a traditional method of extracting an impedance parameter through an electromagnetic numerical calculation method and a network impedance analyzer, in the method of the invention, a complex motor or cable model does not need to be established and a process is simple and is easy to realize. During an impedance extraction process of the traditional method, a port impedance of a motor which does not work is extracted. And in the common code impedance extraction method of the invention, an influence of motor operation on the port impedance is considered so that a common mode current of a motor side can be accurately predicted.

The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, measuring first impedances of the wells and optionally determining first cell indices from the first impedances, adding a compound to at least one well containing test cells to form at least one compound well and adding a vehicle control to at least another well containing test cells to form at least one control well, measuring second impedances of the compound well and the control well and optionally determining second cell indices from the second impedances, determining the change in the impedance or cell index for the compound well and the one control well, comparing the change in impedance or cell index between the compound well and the control well, and identifying the compound interacts with the GPCR or RTK if the comparison demonstrates a significant difference between the change in impedance or cell index of the compound well and the control well.

The invention discloses an online particle detection device and method based on a microfluidic chip. The online particle detection device comprises the microfluidic chip, a first impedance analyzer and a second impedance analyzer, wherein the microfluidic chip comprises a substrate part and a main chip body arranged on the substrate part; the main chip body comprises a first liquid inlet, a second liquid inlet, a first liquid outlet and a second liquid outlet formed in the substrate part, a particle separation region for separating ferromagnetic particles from non-ferromagnetic particles in oil liquid under the action of a magnetic field, a magnetic part placement region arranged on the substrate plate and located on one side of a first microchannel, a magnetic part placed on the magnetic part placement region and used for providing the magnetic field, and a particle detection region. The online particle detection device and method provided by the invention can realize the distinguishing and the online continuous counting of the ferromagnetic particles and the non-ferromagnetic particles in the oil liquid, and is suitable for online detection and analysis of oil liquid, in particular the detection and analysis of oil liquid on sailing ships.

Electrodes for a bio-impedance measuring device or a body composition monitor, the electrodes being integral with or being attached to a surface of at least one device belonging to a group of electronic and / or non-electronic devices used in the preparation of a dialysis treatment or during dialysis, in particular during peritoneal dialysis, the group preferably consisting of organizers of a continuous ambulatory peritoneal dialysis system (CAPD), automated peritoneal dialysis devices, automated peritoneal dialysis-cyclers (APD-Cycler), bioelectrical impedance analyzers (BIA), body composition monitors (BCM), hand-held electrodes holders for the electrodes, and dialysis apparatuses. Devices and methods used during dialysis are also described.

Methods of assessing cytolysis of cancer cells, including providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, wherein the device comprises a well for receiving cells and an electrode array at a base of the well; adding target cells characterized as cancer cells to the well; adding effector cells to the well to form a test well, wherein the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance based parameter over time.

In certain aspects of the invention, a stackable device includes multiple elements stacked sequentially. A chamber is formed in each of the elements or between adjacent two of the elements, and each chamber is in fluid communication with an input channel and an output channel. The chambers are aligned with each other, and adjacent two chambers are separated from each other by a membrane. In certain aspects of the invention, a system includes at least one stackable device, each stackable device having multiple chambers; and at least one of a perfusion controller, a microformulator, and a microclinical analyzer in fluid communication with the at least one stackable device. In other aspects of the invention, the use of four microformulators, electrodes and an impedance analyzer can measure the impedance spectrum of each barrier in a multi-transwell plate.