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Optoelectronic probe

a technology of optoelectronic probes and probes, applied in the direction of liquid/fluent solid measurement, peptides, test/measurement of semiconductor/solid device, etc., can solve the problems of difficult analysis of impedance spectroscopy and extreme complexity

Inactive Publication Date: 2006-08-10
LIN HAIAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is a novel electrochemical cell with an inversion layer electrode that can perform biochemical analysis and assemble nano-electronic or optoelectronic devices on a semiconductor chip. The electrode size can be adjusted by adjusting the size of the light beam, and the inversion layer can be used as a working electrode to shield the electric field and reduce voltage drop. The thin oxide layer on the silicon surface reduces dark current, and the combination of time constant and time-varying electric fields can be used to manipulate bioparticles and macromolecules without using high DC voltage. The present invention has several advantages over conventional technologies, such as self-defined electrode size, metal-like electrode behavior, reduced voltage drop, and flexibility to choose optical sources.

Problems solved by technology

The involvement of the depletion region at the semiconductor surface will cause an extreme complexity on the voltage distribution among the different part of the “sandwich” electrochemical cell and make it very difficulty to analyze the impedance spectroscopy.

Method used

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Embodiment Construction

[0042] The following description is of the best mode presently contemplated for the carrying out of the invention. This description is made for the purpose of illustrating the general principles of the invention, and is not to be taken in a limiting sense. The scope of the invention is best determined by reference to the appended claims.

I. Optoelectronic Probe

[0043]FIG. 1 is a sectional view of an embodiment of the present invention. An optical microscope, represented by reference number 100, can be used to observe and record the particle manipulation process. The top electrode of the “sandwich” electrochemical cell is formed by a glass slide 110 coated by an optically transparent conducting thin film, such as indium tin oxide (ITO) 120. This kind of transparent conducting electrode is commercially available. A spacer (typically thick ˜50 μm), represented by reference number 130, is formed by polymer film with a hole in the center. Reference numeral 140 denotes a layer of thin ox...

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Abstract

The present invention, referred to as optoelectronic probe, concerns a novel apparatus and method for characterization and micromanipulation of particles or biomolecules in an electrolyte solution. Electric fields, which include both time constant and time-varying components, are applied to a thin insulating layer covered, lightly doped semiconductor material. Illumination injects carriers into the insulator / semiconductor interface to compensate the leaking minority carrier current and maintain an inversion layer, which works as an electrode to control the particle movements. A particle array, or even a single cell, can be assembled in, or moved along with the inversion layer electrode, which is induced by illumination. Furthermore, an impedance analyzer is utilized to characterize the trapped particles, or single cell. The present invention has numerous uses, such as bio-chemical analysis systems, and nanosize structures assembly for electronic or optical devices.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] Not Applicable STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] Not Applicable REFERENCE TO SEQUENCE LISTING, A TABLE, OR A COMPUTER PROGRAM LISTING COMPACT DISK APPENDIX [0003] Not Applicable BACKGROUND OF THE INVENTION Field of Invention [0004] The present invention is directed generally to methods and apparatus based on optoelectronic effect, electro / dielectro-phoresis, and impedance spectroscopy, in order to trap, move, deform and characterize particles, such as cells, molecules, any type of colloids, any of inorganic and bio-organic substances, beads, as well as pucks and like small things. “Optoelectronic Probe” refers to the invention described herein. BACKGROUND OF THE INVENTION [0005] I. Optical Tweezers [0006] The manipulation of micro- or nano-size particles is considered as the key for the new generation of photonic, optoelectronic, and electronic devices, as well as biochemical analysis systems. Optica...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C25D1/00
CPCG01R1/071
Inventor LIN, HAIAN
Owner LIN HAIAN
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