The invention discloses a transcranial time interference
stimulation parameter optimization system and method, and belongs to the technical field of nerve regulation and control. The
system comprises a tTIS stimulator, an
electrode array, a control module and a calculation module. According to the
system, two paths of high-frequency
carrier current with a specific
frequency difference generated by the tTIS stimulator interfere in a target
brain region to generate a low-frequency envelope
electric field, so that accurate non-invasive regulation and control on a deep
brain region are realized. The
system constructs a personalized
head model based on head image data of a subject, and optimizes an
electrode application position; the control module executes a preset stimulation protocol, preferentially fixes the stimulation duration and the envelope frequency, allows the current intensity to be adjusted within a safe range, and is provided with an automatic stop mechanism to prevent excessive treatment. The invention is particularly suitable for treating human
chronic pain through targeted regulation of the ventral
prefrontal cortex (vmPFC), the regulation principle is verified in a mouse model, and the
drug has the characteristics of accurate stimulation, high safety, lasting
curative effect and the like.