Preparation method and application of 3D print microacupuncture needle paster

Abstract

The invention discloses a preparation method and application of a 3D print microacupuncture needle paster, and belongs to the field of biomaterials and biological manufacturing. A dual-spray-head melting deposition shaping FDM 3D printer is used, a spray head is used for printing a base of the microacupuncture needle paster, and the other spray head is used for printing a columnar array of the microacupuncture needle paster, wherein the columnar array contains insulin medicines which can intelligently respond to and adjust blood sugar. After the base and the columnar array are obtained, a slide is in contact with the top end of the columnar array, then the top end is stretched to a preset distance to produce a needle point of the microacupuncture needle, cross-linking shaping is performed,and after dewatering and drying are completed under natural state, a microacupuncture needle array paster having certain mechanical properties and containing responsiveness medicines is formed. The microacupuncture needle paster can puncture skin, can intelligently respond according to blood sugar concentration in vivo, can intelligently release loaded medicines, and can intelligently adjust thelevel of the blood sugar. In a 3D print microacupuncture needle manner, painless intelligent response type blood sugar adjustment capable of realizing skin puncture can be realized, and the 3D print microacupuncture needle paster hopefully guides diagnosis and treatment integration of diabetes.

Description

technical field [0001] The invention belongs to the field of biomaterials and biomanufacturing, and more specifically relates to a preparation method and application of a 3D printed microneedle array patch for minimally invasive, intelligent release of insulin and intelligent regulation of blood sugar. Background technique [0002] Diabetes is one of the most challenging health problems of the 20th century. Diabetes is a metabolic disease that results in high blood sugar in the body due to insufficient insulin secretion in the body (type 1 diabetes) or due to the inability of the body to effectively use insulin (type 2 diabetes). A classic clinicopathological feature of diabetes is dysregulation of blood glucose, and traditional care for patients with diabetes usually requires monitoring of blood glucose and subcutaneous insulin injections to maintain euglycemia. However, this form of self-administration is often accompanied by pain and uneven drug delivery. Poorly control...

AI Technical Summary

Problems solved by technology

[0005] In view of the above defects or improvement needs of the prior art, the present invention proposes a preparation method and application of a 3D printed microneedle patch, thereby solving the problem that the number of existing microneedle arrays and other characteristic parameters cannot be modified arbitrarily, Technical problems that lead to limited application

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