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Preparation method and application of 3D print microacupuncture needle paster

A technology of 3D printing and microneedle sticking, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, sheet-like delivery, etc. It can solve the problems of limited application, the number of microneedle arrays and other characteristic parameters The problem of being arbitrarily modified, etc., to achieve the effect of controllable and adjustable parameters, convenient production process, and mild reaction conditions

Active Publication Date: 2020-01-17
WUHAN UNIV
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Problems solved by technology

[0005] In view of the above defects or improvement needs of the prior art, the present invention proposes a preparation method and application of a 3D printed microneedle patch, thereby solving the problem that the number of existing microneedle arrays and other characteristic parameters cannot be modified arbitrarily, Technical problems that lead to limited application

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  • Preparation method and application of 3D print microacupuncture needle paster
  • Preparation method and application of 3D print microacupuncture needle paster
  • Preparation method and application of 3D print microacupuncture needle paster

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Embodiment Construction

[0039] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, but not to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not constitute a conflict with each other.

[0040] The present invention provides a 3D printed microneedle patch based on fused deposition modeling (FDM), that is, the preparation of an intelligent, minimally invasive microneedle patch that can release insulin in real time in response to blood sugar concentration in the body and regulate blood sugar in the body to a normal level method and its application. The design uses curable mat...

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Abstract

The invention discloses a preparation method and application of a 3D print microacupuncture needle paster, and belongs to the field of biomaterials and biological manufacturing. A dual-spray-head melting deposition shaping FDM 3D printer is used, a spray head is used for printing a base of the microacupuncture needle paster, and the other spray head is used for printing a columnar array of the microacupuncture needle paster, wherein the columnar array contains insulin medicines which can intelligently respond to and adjust blood sugar. After the base and the columnar array are obtained, a slide is in contact with the top end of the columnar array, then the top end is stretched to a preset distance to produce a needle point of the microacupuncture needle, cross-linking shaping is performed,and after dewatering and drying are completed under natural state, a microacupuncture needle array paster having certain mechanical properties and containing responsiveness medicines is formed. The microacupuncture needle paster can puncture skin, can intelligently respond according to blood sugar concentration in vivo, can intelligently release loaded medicines, and can intelligently adjust thelevel of the blood sugar. In a 3D print microacupuncture needle manner, painless intelligent response type blood sugar adjustment capable of realizing skin puncture can be realized, and the 3D print microacupuncture needle paster hopefully guides diagnosis and treatment integration of diabetes.

Description

technical field [0001] The invention belongs to the field of biomaterials and biomanufacturing, and more specifically relates to a preparation method and application of a 3D printed microneedle array patch for minimally invasive, intelligent release of insulin and intelligent regulation of blood sugar. Background technique [0002] Diabetes is one of the most challenging health problems of the 20th century. Diabetes is a metabolic disease that results in high blood sugar in the body due to insufficient insulin secretion in the body (type 1 diabetes) or due to the inability of the body to effectively use insulin (type 2 diabetes). A classic clinicopathological feature of diabetes is dysregulation of blood glucose, and traditional care for patients with diabetes usually requires monitoring of blood glucose and subcutaneous insulin injections to maintain euglycemia. However, this form of self-administration is often accompanied by pain and uneven drug delivery. Poorly control...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/36A61K47/04A61K47/42A61K38/28A61P3/10B33Y10/00B33Y80/00
CPCA61K9/0021A61K9/70A61K38/28A61K47/02A61K47/36A61K47/42A61P3/10B33Y10/00B33Y80/00
Inventor 雷祎凤武明信黄赫李静雯刘海洋郭赵阳
Owner WUHAN UNIV
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