A preparation method and application of 3D printing microneedle patch

A 3D printing and microneedle sticking technology, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, sheet delivery, etc. It can be arbitrarily modified, etc., to achieve the effects of controllable and adjustable parameters, convenient production process, and simple preparation method.

Active Publication Date: 2021-01-26
WUHAN UNIV
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Problems solved by technology

[0005] In view of the above defects or improvement needs of the prior art, the present invention proposes a preparation method and application of a 3D printed microneedle patch, thereby solving the problem that the number of existing microneedle arrays and other characteristic parameters cannot be modified arbitrarily, Technical problems that lead to limited application

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  • A preparation method and application of 3D printing microneedle patch
  • A preparation method and application of 3D printing microneedle patch
  • A preparation method and application of 3D printing microneedle patch

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[0039] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, but not to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not constitute a conflict with each other.

[0040] The present invention provides a 3D printed microneedle patch based on fused deposition modeling (FDM), that is, the preparation of an intelligent, minimally invasive microneedle patch that can release insulin in real time in response to blood sugar concentration in the body and regulate blood sugar in the body to a normal level method and its application. The design uses curable mat...

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Abstract

The invention discloses a preparation method and application of a 3D printed microneedle patch, which belongs to the field of biological materials and biomanufacturing. The FDM 3D printer uses double nozzles for fused deposition molding. One nozzle is used to print the base of the microneedle patch, and the other A single nozzle prints a columnar array of microneedle patches containing insulin drugs that respond intelligently to regulate blood sugar. After the substrate and the columnar array are obtained, contact the top of the columnar array with a glass slide, and stretch it to a predetermined distance to produce a microneedle tip, which is cross-linked and formed. After dehydration and drying in the natural state, a microneedle with certain mechanical properties and responsive Microneedle array patch for drugs. The microneedle patch can puncture the skin and respond intelligently in the body according to the blood sugar concentration, intelligently release the contained drugs, and intelligently regulate the blood sugar level. Through 3D printing microneedles, painless, skin-punctured, intelligent and responsive blood sugar regulation can be realized, which is expected to guide the integration of diagnosis and treatment of diabetes.

Description

technical field [0001] The invention belongs to the field of biomaterials and biomanufacturing, and more specifically relates to a preparation method and application of a 3D printed microneedle array patch for minimally invasive, intelligent release of insulin and intelligent regulation of blood sugar. Background technique [0002] Diabetes is one of the most challenging health problems of the 20th century. Diabetes is a metabolic disease that results in high blood sugar in the body due to insufficient insulin secretion in the body (type 1 diabetes) or due to the inability of the body to effectively use insulin (type 2 diabetes). A classic clinicopathological feature of diabetes is dysregulation of blood glucose, and traditional care for patients with diabetes usually requires monitoring of blood glucose and subcutaneous insulin injections to maintain euglycemia. However, this form of self-administration is often accompanied by pain and uneven drug delivery. Poorly control...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/36A61K47/04A61K47/42A61K38/28A61P3/10B33Y10/00B33Y80/00
CPCA61K9/0021A61K9/70A61K38/28A61K47/02A61K47/36A61K47/42A61P3/10B33Y10/00B33Y80/00
Inventor 雷祎凤武明信黄赫李静雯刘海洋郭赵阳
Owner WUHAN UNIV
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