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Micro-processing gas matching layer modulation body ultrasonic cell assembling and arranging device, preparation method and application

A technology for arrangement devices and matching layers, which is applied in tissue cell/virus culture devices, biochemical equipment and methods, enzymology/microbiology devices, etc., can solve the problem that cells cannot be arranged tightly and orderly, and it is difficult to realize arbitrary patterns of cells issues such as globalization, to achieve the effect of huge application prospects and commercial value

Active Publication Date: 2021-06-04
SHENZHEN CONVERGENCE BIO-MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to achieve arbitrary patterning of cells, and cannot meet the needs of tight and orderly arrangement of cells in the field of biomanufacturing and the construction of macro-scale human microtissues and micro-organs in vitro in the field of tissue engineering.

Method used

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  • Micro-processing gas matching layer modulation body ultrasonic cell assembling and arranging device, preparation method and application
  • Micro-processing gas matching layer modulation body ultrasonic cell assembling and arranging device, preparation method and application
  • Micro-processing gas matching layer modulation body ultrasonic cell assembling and arranging device, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Using soft lithography to process a simple patterned acoustic matching layer for assembly and alignment of polystyrene microspheres

[0044] like figure 1 As shown, the device for assembling and arranging polystyrene microspheres using soft lithography to process an acoustic matching layer according to an embodiment of the present invention includes an arbitrary waveform function generator 1, a cell assembly chamber 3, a micropattern structure matching layer 5 and an ultrasonic Transducer 2. In this embodiment, the cell assembly chamber 3 is composed of a cell culture dish 4 , the micropattern structure matching layer 5 is located at the outer bottom of the cell culture dish 4 , and the ultrasonic transducer 2 is located at the bottom of the micropattern structure matching layer 5 .

[0045] The model of the arbitrary waveform function generator 1 is AFG3000, which has a dual-channel design, a maximum sampling rate of 1GS / s, an output frequency of up to 100MH...

Embodiment 2

[0056] Example 2 Using soft lithography technology to process complex patterned acoustic matching layer to assemble and arrange polystyrene microspheres

[0057] like figure 1 As shown, the device for assembling and arranging polystyrene microspheres using soft lithography to process an acoustic matching layer according to an embodiment of the present invention includes an arbitrary waveform function generator 1, a cell assembly chamber 3, a micropattern structure matching layer 5 and an ultrasonic Transducer 2. In this embodiment, the cell assembly chamber 3 is composed of a cell culture dish 4 , the micropattern structure matching layer 5 is located at the outer bottom of the cell culture dish 4 , and the ultrasonic transducer 2 is located at the bottom of the micropattern structure matching layer 5 .

[0058] The model of the arbitrary waveform function generator 1 is AFG3000, which has a dual-channel design, a maximum sampling rate of 1GS / s, an output frequency of up to 1...

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Abstract

The invention belongs to the technical field of tissue engineering and biological manufacturing under biomedical engineering, and particularly relates to a micro-processing gas matching layer modulation body ultrasonic cell assembling and arranging device, a preparation method and application. According to the micro-processing gas matching layer modulation body ultrasonic cell assembling and arranging method and device, a sound field generated by an ultrasonic transducer is modulated by processing an acoustic matching layer micro-pattern structure, and cells are assembled and randomly arranged in a cell assembling chamber. According to the device, the acoustic matching layer is processed by utilizing a soft lithography technology for the first time to modulate the sound field for cell assembling, so that a more flexible body ultrasonic sound field style is realized, the device can be more suitable for various cell control requirements of biological research and tissue engineering, and the device has huge application prospects and commercial values.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering and biomanufacturing under the biomedical engineering, and in particular relates to a micromachining gas matching layer modulation body ultrasonic cell assembling and arranging device, preparation method and application. Background technique [0002] In the field of tissue engineering, the orderly assembly and manipulation of cells is playing an increasingly important role in the controllable growth of cells, because the communication and function realization of many cells are based on certain shape and structure signals, so in order to achieve specific tissue functions And to guide a specific direction of differentiation, cells and other samples need to be arranged and assembled according to a specific structure. Most of the traditional cell arrangement methods use molds for passive cell solution arrangement. This method can only arrange the cell solution and cannot directly act on sma...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/42C12M1/22
CPCC12M23/16C12M23/10C12M35/02C12M35/04
Inventor 陈璞陈司晗徐放
Owner SHENZHEN CONVERGENCE BIO-MFG CO LTD
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