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A microfabricated gas matching layer modulated bulk ultrasonic cell assembly and arrangement device, preparation method and application

A technology for arrangement devices and matching layers, which is applied in tissue cell/virus culture devices, biochemical equipment and methods, enzymology/microbiology devices, etc., can solve the problem that cells cannot be arranged tightly and orderly, and it is difficult to realize arbitrary patterns of cells issues such as globalization, to achieve the effect of huge application prospects and commercial value

Active Publication Date: 2022-08-05
SHENZHEN CONVERGENCE BIO-MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to achieve arbitrary patterning of cells, and cannot meet the needs of tight and orderly arrangement of cells in the field of biomanufacturing and the construction of macro-scale human microtissues and micro-organs in vitro in the field of tissue engineering.

Method used

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  • A microfabricated gas matching layer modulated bulk ultrasonic cell assembly and arrangement device, preparation method and application
  • A microfabricated gas matching layer modulated bulk ultrasonic cell assembly and arrangement device, preparation method and application
  • A microfabricated gas matching layer modulated bulk ultrasonic cell assembly and arrangement device, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Using soft lithography to process simple patterned acoustic matching layers for assembly and arrangement of polystyrene microspheres

[0044] like figure 1 As shown, the apparatus for assembling and arranging polystyrene microspheres by processing an acoustic matching layer with soft lithography according to an embodiment of the present invention includes an arbitrary waveform function generator 1, a cell assembly chamber 3, a micropatterned structure matching layer 5, and an ultrasonic Transducer 2. In this embodiment, the cell assembly chamber 3 is composed of a cell culture dish 4 , the micro-patterned structure matching layer 5 is located at the outer bottom of the cell culture dish 4 , and the ultrasonic transducer 2 is located at the bottom of the micro-patterned structure matching layer 5 .

[0045] Arbitrary waveform function generator 1 is AFG3000, with a dual-channel design, the maximum sampling rate is 1GS / s, the output frequency is up to 100MHz, a...

Embodiment 2

[0056] Example 2 Using soft lithography to process complex pattern acoustic matching layers for assembly and arrangement of polystyrene microspheres

[0057] like figure 1 As shown, the apparatus for assembling and arranging polystyrene microspheres by processing an acoustic matching layer with soft lithography according to an embodiment of the present invention includes an arbitrary waveform function generator 1, a cell assembly chamber 3, a micropatterned structure matching layer 5, and an ultrasonic Transducer 2. In this embodiment, the cell assembly chamber 3 is composed of a cell culture dish 4 , the micro-patterned structure matching layer 5 is located at the outer bottom of the cell culture dish 4 , and the ultrasonic transducer 2 is located at the bottom of the micro-patterned structure matching layer 5 .

[0058] Arbitrary waveform function generator 1 is AFG3000, with a dual-channel design, the maximum sampling rate is 1GS / s, the output frequency is up to 100MHz, an...

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Abstract

The invention belongs to the technical field of tissue engineering and biomanufacturing subordinate to biomedical engineering, and particularly relates to a microfabricated gas matching layer modulated bulk ultrasonic cell assembly and arrangement device, preparation method and application. The microfabricated gas matching layer modulates the method and device for assembling and arranging bulk ultrasonic cells of the present invention. The acoustic field generated by the ultrasonic transducer is modulated by processing the acoustic matching layer micropattern structure, and the cells are assembled in the cell assembly chamber. and any arrangement. For the first time, this device uses soft lithography to process an acoustic matching layer to modulate the sound field for cell assembly, and realizes a more flexible volumetric ultrasonic sound field pattern, making it more suitable for various biological research and tissue engineering. Application prospects and business value.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering and biomanufacturing subordinate to biomedical engineering, and particularly relates to a microfabricated gas matching layer modulated bulk ultrasonic cell assembly and arrangement device, preparation method and application. Background technique [0002] In the field of tissue engineering, the orderly assembly and manipulation of cells plays an increasingly important role in controllable cell growth. Because many cells communicate and function based on certain shape and structure signals, in order to achieve specific tissue functions And to guide a specific differentiation direction, it is necessary to arrange and assemble samples such as cells according to a specific structure. Most of the traditional cell arrangement methods use molds for passive cell solution arrangement. This method can only arrange cell solutions and cannot directly act on cells of smaller size, and the substrate w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12M1/42C12M1/22
CPCC12M23/16C12M23/10C12M35/02C12M35/04
Inventor 陈璞陈司晗徐放
Owner SHENZHEN CONVERGENCE BIO-MFG CO LTD
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