Hexagonal surface wave acoustic tweezer chip for cell arrangement and assembly

Abstract

The invention discloses a hexagonal surface wave acoustic tweezer chip for cell arrangement and assembly. The hexagonal surface wave acoustic tweezer chip includes a hexagonal acoustic tweezer and a microfluidic cavity, a Z-cut lithium niobate piezoelectric substrate is used, six interdigital transducers are made on the substrate, through the combination of different beams and individual phase modulation of the beams, sound field patterns far more than traditional acoustic tweezers can be produced, a sound field structure is also more flexible and adjustable, and when the chip is used for cellmanipulation and assembly, a more diverse assembly structure and more powerful control ability are provided. Through the individual modulation and combination application of the transducers, multi-wave interference can be carried out in the way, a variety of sound field structures and flexible regulation are realized. The hexagonal surface wave acoustic tweezer chip can be more suitable for various application scenarios that require cell manipulation and assembly without damage and contact, a more flexible surface wave sound field pattern is realized, the hexagonal surface wave acoustic tweezer chip is more suitable for various cell manipulation needs of biological research and tissue engineering, and the application prospects are huge.

Description

technical field [0001] The invention relates to the technical field of biological tissue engineering, in particular to a hexagonal surface wave acoustic tweezer chip used for cell arrangement and assembly. Background technique [0002] In the field of biological tissue engineering, the orderly assembly and manipulation of cells plays an increasingly important role in controllable cell growth. Because many cells communicate and function based on certain shape and structure signals, in order to achieve specific tissue To function and guide a specific direction of differentiation, cells and other samples need to be arranged and assembled according to a specific structure. Most of the traditional cell arrangement methods use molds for passive cell solution arrangement. This method can only arrange cell solutions and cannot directly act on cells of smaller size, and the substrate with limited contact with cells will transmit cell information. and cell growth have a negative impa...

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Problems solved by technology

However, since traditional acoustic tweezers mostly use two beams of standing waves for interference, the sound field patterns that can be provided are very limited, and it is difficult to meet the flexible arrangement of cells in tissue engineering and other biological research.

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