A hexagonal surface wave acoustic tweezers chip for cell arrangement and assembly

Abstract

The invention discloses a hexagonal surface wave acoustic tweezers chip for cell arrangement and assembly. The chip includes a hexagonal acoustic tweezers and a microfluidic cavity, and uses a Z-cut lithium niobate piezoelectric substrate, and fabricated on the substrate Six interdigital transducers, through different beam combinations and individual modulation of the phase of each beam, can generate far more sound field patterns than traditional acoustic tweezers, and the sound field structure is also more flexible and adjustable. When used for cell manipulation assembly, it provides More diverse assembly structures and more powerful control capabilities. Individual modulation and combined application of each transducer, and multi-wave interference based on this, realize various sound field structures and flexible regulation. The present invention can be more suitable for various application scenarios that require cell manipulation and assembly, without damage and without contact, and realizes a more flexible surface wave sound field pattern, making it more suitable for various biological research and tissue engineering cell manipulation requirements. Huge application prospects.

Description

technical field [0001] The invention relates to the technical field of biological tissue engineering, in particular to a hexagonal surface wave acoustic tweezers chip for cell arrangement and assembly. Background technique [0002] In the field of biological tissue engineering, the orderly assembly and manipulation of cells is playing an increasingly important role in the controllable growth of cells, because the communication and function realization of many cells are based on certain shape and structure signals, so in order to achieve specific tissue To function and guide a specific direction of differentiation, cells and other samples need to be arranged and assembled according to a specific structure. Most of the traditional cell arrangement methods use molds for passive cell solution arrangement. This method can only arrange the cell solution and cannot directly act on smaller-sized cells, and the substrate with limited contact with cells will interfere with the transmi...

AI Technical Summary

Problems solved by technology

However, since traditional acoustic tweezers mostly use two beams of standing waves for interference, the sound field patterns that can be provided are very limited, and it is difficult to meet the flexible arrangement of cells in tissue engineering and other biological research.

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