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Blood flow measurement system using adherent laser speckle contrastive analysis

A technique of light scattering and contrast used in blood flow measurement, analysis using fluorescence emission, diagnostics using spectroscopy, etc.

Pending Publication Date: 2021-12-03
柯惠股份公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, specular and diffuse reflections lead to unwanted signal content being included in the LSI measurement

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  • Blood flow measurement system using adherent laser speckle contrastive analysis
  • Blood flow measurement system using adherent laser speckle contrastive analysis
  • Blood flow measurement system using adherent laser speckle contrastive analysis

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Embodiment Construction

[0033] Novel methods, devices, and systems for determining more accurate rates of movement (eg, flow rates, diffusion rates, etc.) of scattering particles within a sample of interest are disclosed herein. In summary, the disclosed embodiments innovatively apply the theory of dynamic light scattering and, in particular, speckle contrast analysis methods. The method of speckle contrast imaging is commonly used to image blood vessels and other vascularized tissues in the field of biomedical engineering. The method exploits the interference patterns formed when coherent laser light is scattered randomly in the sample medium. A so-called speckle pattern is formed on the image sensor. If the scattering object is in motion, the speckle pattern will fluctuate during the image sensor's exposure time, which will cause the pattern to blur. For a given camera exposure, faster fluctuations cause more blur. One measure of "blur" in speckle images is commonly known as speckle contrast, an...

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Abstract

The invention relates to a blood flow measurement system using adherent laser speckle contrastive analysis. Disclosed herein are devices, systems, and methods for improved laser speckle imaging of a sample, such as vascularized tissue. The laser speckle imaging is used for determining the movement rate of the light scattering particles in the sample. The system includes a structure adjoining the light source and the photosensitive detector. The structure may be positioned adjacent the sample (e.g., coupled to the sample) and configured to face the light source and the detector relative to the sample such that surfaces including specular and diffuse reflections are not prevented from reflecting into the detection field of the detector. The separation distance along the structure between the light source and the detector may further enable selective depth penetration into the sample and biased sampling of multiple scattered photons. The system includes a processor operably coupled; the processor is programmed to derive a contrast metric from the detector and correlate the contrast metric with a rate of movement of the light scattering particles.

Description

[0001] This application is a divisional application of PCT application No. 201780029605.5, which entered the Chinese national phase with an international filing date of April 4, 2017, and the title of the invention is "Blood Flow Measurement System Using Adhesive Laser Speckle Contrast Analysis". [0002] Incorporated herein by reference [0003] This application claims the benefit of priority to US Provisional Patent Application No. 62 / 318,884, filed April 6, 2016, which is hereby incorporated by reference in its entirety for all purposes. Any and all applications through or from this Provisional Patent Application to which it is related by way of priority are hereby incorporated by reference in their entirety. technical field [0004] Embodiments of the present disclosure relate to novel methods, devices, and systems for optical, non-invasive measurement of the rate of movement of light scattering particles within a sample of interest. In particular, the present disclosure ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B5/026A61B5/028G01F1/708G01F1/712G01N15/02G02B27/48G01F1/7086
CPCA61B5/028G01F1/7086G01F1/712G01N15/0211A61B5/026A61B5/0066A61B5/6802A61B5/681G01N15/0227G02B27/48A61B5/0071A61B5/0075A61B5/0261A61B5/0059A61B2562/0233A61B2562/185G01N2015/0222G01N15/01
Inventor 泰勒·拜沃特斯·莱斯肖恩·迈克尔·怀特杨毅
Owner 柯惠股份公司
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