Method for monitoring micro circulation blood flow time-space response characteristic on mesentery by using laser speckle imaging instrument

Abstract

The equipment for monitoring micro circulation body flow time-space response characteristic on mesentery includes an optical path and an imaging system. In the optial path, the laser bean from helium neon laser is coupled to fiber bundle to form homogeneous diffused beam; and the imaging system consists of stereo microscope with CCD camera, image collecting card with image collecting and controlling software. The CCD signal is output to the image collecting card connected to PC, the collection parameters are set via the image collecting and controlling software and local blood flow information are obtained with the image signal and via the signal analysis software. The equipment provides one new way to the research of influence of medicine and other stimulation to the micro circulation blood flow on mesentery.

Description

technical field

[0001] The invention relates to a method for monitoring the temporal-spatial response characteristics of mesenteric microcirculation blood flow using a laser speckle imager, and is particularly suitable for using reflection imaging methods to study the regional blood flow velocity of supra mesenteric microcirculation under the action of drugs and other stimuli , pipe diameter, and flow change. Background technique

[0002] At present, a large number of studies exploring the effects of drugs on the microcirculation in vivo use the transparency of the mesentery as an observation sample of the microcirculation. In these studies, the parameters of microcirculation in the mesentery were monitored by means of optical microscope, microvideo video system and laser Doppler microscope. Since these methods use the transmission method for measurement, the measurement object can only be the capillary with better transparency, but cannot measure the blood vessel with poor...

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