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Multi-spectral laser imaging (MSLI) methods and systems for blood flow and perfusion imaging and quantification

A multi-spectral imaging and imaging technology, applied in blood flow measurement, applications, medical images, etc., can solve problems such as lack of tissue/organ penetration, and non-inherent tissue/organ physiological characteristics

Inactive Publication Date: 2017-12-01
EAST CAROLINA UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, unlike NIR light, UV or visible light imaging is generally not inherently capable of revealing tissue / organ physiology in subsurface layers, in part due to lack of tissue / organ penetration

Method used

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  • Multi-spectral laser imaging (MSLI) methods and systems for blood flow and perfusion imaging and quantification
  • Multi-spectral laser imaging (MSLI) methods and systems for blood flow and perfusion imaging and quantification
  • Multi-spectral laser imaging (MSLI) methods and systems for blood flow and perfusion imaging and quantification

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Embodiment Construction

[0041] Embodiments of the inventive concept will now be described more fully hereinafter with reference to the accompanying drawings, in which preferred embodiments of the inventive concept are shown. This inventive concept may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Like reference numerals refer to like elements throughout. In the drawings, layers, regions, elements or components may be exaggerated for clarity. Broken lines illustrate optional features or operations unless otherwise specified.

[0042] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the inventive concepts. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly dictates otherwise. It will be further understood that the terms "comprising" and / or "comprising" when used in thi...

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Abstract

Some embodiments of the present inventive concept provide a system that uses two wavelengths of differential transmittance through a sample to apply laser speckle or laser Doppler imaging. A first of the two wavelengths is within the visible range that has zero or very shallow penetration. This wavelength captures the anatomical structure of tissue / organ surface and serves as a position marker of the sample but not the subsurface movement of blood flow and perfusion. A second wavelength is in the near Infra-Red (NIR) range, which has much deeper penetration. This wavelength reveals the underlying blood flow physiology and correlates both to the motion of the sample and also the movement of blood flow and perfusion. Thus, true motion of blood flow and perfusion can be derived from the NIR imaging measurement without being affected by the motion artifact of the target.

Description

[0001] claim priority [0002] The request for this application is entitled " Multi-Spectral Laser Imaging (MSLI) Methods and Systems for Blood Flow and Perfusion Imaging and Quantification ”, the benefit and priority of U.S. Provisional Application Serial No. 62 / 136,010, filed March 20, 2015, the disclosure of which is hereby incorporated by reference as if set forth in its entirety. [0003] Copyright Reservation [0004] Portions of the disclosure of this patent document contain copyrighted material. The owner of the copyright (EastCarolina University of Greenville, N.C.), has no objection to the reproduction by anyone of the patent document or patent disclosure as it appears in the Patent and Trademark Office patent file or records, but otherwise All copyright rights reserved regardless. technical field [0005] The inventive concept relates generally to blood flow and perfusion quantification, and more particularly to the use of imaging techniques such as laser speck...

Claims

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Application Information

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IPC IPC(8): A61B5/026A61B5/00
CPCA61B5/0077A61B5/0261A61B5/7207A61B5/721A61B5/7271A61B2576/00A61B5/0035G16H30/40
Inventor 陈成T.B.小费尔古森Z.彭K.M.雅各布斯
Owner EAST CAROLINA UNIVERISTY
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