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Cortical functional multi-mode imaging system

An imaging system, multi-functional technology, applied in the field of biomedical imaging, to achieve simple effects

Active Publication Date: 2010-12-29
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0003] The patent of the present invention provides an imaging device that can simultaneously monitor the intracellular pH value of the cerebral cortex, cerebral blood volume, deoxygenated hemoglobin and cerebral blood flow, which solves the problem of coupling multiple imaging modes for a long time

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  • Cortical functional multi-mode imaging system
  • Cortical functional multi-mode imaging system
  • Cortical functional multi-mode imaging system

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Embodiment Construction

[0015] Such as figure 1 Shown: the device includes a dichroic prism 1, a first charge-coupled device 4, a second charge-coupled device 3, a liquid crystal tunable filter 12 and a controller 14 thereof, a first computer 6, a second computer 5, a first filter Light sheet 2 , second filter 8 , third filter 9 , wide-spectrum light source 7 , laser diode 11 , red light-emitting diode 10 and its control circuit 13 .

[0016] Broad-spectrum light source, laser diode (660 nm) and red light-emitting diode are scattered above the cerebral cortex, and the backscattered light from the cerebral cortex is divided into two paths by a dichroic prism 1, and one path passes through the first optical filter 2 (655 nm) -665 nm) was detected by the second charge-coupled device 3. The other path passes through the liquid crystal tunable filter 12 and is detected by the first charge coupler 4. It is an innovative point of the patent of the present invention to introduce the liquid crystal tunable f...

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Abstract

The invention discloses a cortical functional multi-mode imaging system. The system comprises a wide-spectrum light source, a laser diode and a red light-emitting diode which are arranged above cortex dispersedly; a coaxial filter is respectively arranged in front of the wide-spectrum light source and the red light-emitting diode; backward scattered light come from the cortex is split into two paths by a dispersion prism; one path of the backward scattered light is connected with a first charge coupled device through a liquid crystal tunable filter; the other path of the backward scattered light is connected with a second charge coupled device through a filter; and the two charge coupled devices are respectively connected with two computers. The system solves the difficult problem of technology integration of fluorescence imaging and intrinsic signal optical imaging for a long time by introducing the liquid crystal tunable filter; and the intracellular pH value, cerebral blood volume, deoxygenated hemoglobin and cerebral blood flow changes can be obtained at the same time by combining laser speckle imaging so as to provide an effective means for researching brain functions and disease mechanisms more completely in detail.

Description

technical field [0001] The patent of the invention belongs to the field of biomedical imaging, and specifically relates to a functional multi-mode imaging system of the cerebral cortex, which can simultaneously monitor the pH value change of the cerebral cortex, the change of cerebral blood volume, the change of deoxygenated hemoglobin concentration and the change of blood flow velocity. It is suitable for the functional study of the cerebral cortex in biomedicine. Background technique [0002] Traditional pH detection mainly uses pH-sensitive electrodes, but this method can only detect a single point and is invasive. The change information of intracellular pH can be obtained by using pH-sensitive dyes for fluorescence imaging; endogenous signal optical imaging is a technique to detect the retroreflected light of the cortex, which mainly reflects the change of hemoglobin concentration; laser speckle imaging is used in It has been widely used to reflect changes in blood flo...

Claims

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Application Information

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IPC IPC(8): A61B5/0205A61B5/00
Inventor 李鹏程骆清铭孙小丽刘睿尹翠
Owner HUAZHONG UNIV OF SCI & TECH
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