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Optical imaging method based on layer structure

A layered structure and optical imaging technology, which is applied in medical science, using spectrum diagnosis, using light for diagnosis, etc., can solve problems such as uneven distribution, inability to accurately restore the spatial distribution of the measured substance, and misestimation of substance content.

Active Publication Date: 2018-03-06
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0002] In the field of optical imaging, the composition of biological tissues is complex and diverse, and not all detected substances are isotropic substances. In fact, biological tissues are anisotropic substances, and the substances in the detected area have spatial inhomogeneity. distribution (such as skin melanin only exists in the epidermis, while oxygenated hemoglobin and hypoxi

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  • Optical imaging method based on layer structure

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Abstract

The invention provides an optical imaging method based on a layer structure. In the method, specific space distribution and optical properties of all substance layers are considered fully, optical information (absorption coefficients and scattering coefficient of all layers) of all the corresponding layers can be separated. By applying the optical information to a biological system, the physiological parameter information (deoxygenated hemoglobin content, oxygen-poor hemoglobin content, melanin content and epidermal depth). For example, the model is combined with the SFDI technology and applied to a forearm reactive congestion experiment and skin mole detection, and a good result is obtained.

Description

technical field [0001] The invention specifically relates to an optical imaging method based on layered structure mapping. Background technique [0002] In the field of optical imaging, the composition of biological tissues is complex and diverse, and not all detected substances are isotropic substances. In fact, biological tissues are anisotropic substances, and the substances in the detected area have spatial inhomogeneity. distribution (such as skin melanin only exists in the epidermis, while oxygenated hemoglobin and hypoxic hemoglobin exist in the dermis), but in actual processing, in order to simplify the actual path of light entering biological tissues, it is considered that the detected substances are Therefore, the material content of each layer will be misestimated, and the spatial distribution, optical and physiological information of the measured material cannot be accurately restored. However, the large-area skin imaging method based on layered structure mappin...

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Application Information

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IPC IPC(8): A61B5/00A61B5/1455
CPCA61B5/0033A61B5/0059A61B5/14551A61B5/441A61B5/443A61B5/0075A61B5/1455A61B5/0077A61B5/72
Inventor 徐敏曾碧新陈新林
Owner WENZHOU MEDICAL UNIV
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