Photoacoustic and ultrasonic bimodal imaging system and method for transplanted kidneys

Abstract

The invention discloses a photoacoustic ultrasonic bimodal imaging system and method for transplanted kidney. The system comprises a pulse laser which is used for the transplanted kidney to generate an photoacoustic signal; the ultrasonic transducer is used for receiving the photoacoustic signal and converting the photoacoustic signal into an electric signal; the ultrasonic transceiving module isused for transmitting and receiving electric signals; a photoacoustic signal processing unit; a data collection unit; and the computer is used for controlling the pulse laser and the ultrasonic transceiving module, performing image reconstruction on the digitized photoacoustic signal to obtain a photoacoustic image, and performing color coding on the photoacoustic image to realize development of functional information such as transplanted kidney microvascular distribution, intravascular blood oxygen content, oxygenated / deoxygenated hemoglobin content and the like. Structural imaging of the transplanted kidney can be achieved, functional information such as castruty distribution, intravascular blood oxygen content and oxygenated / deoxygenated hemoglobin content of the transplanted kidney canbe provided, and namely simultaneous real-time imaging of the structure and the function of the transplanted kidney is achieved.

Description

technical field [0001] The invention relates to the technical field of medical measurement, in particular to a photoacoustic ultrasonic dual-mode imaging system and a method thereof for transplanted kidneys. Background technique [0002] Kidney transplantation is an effective means of treating patients with end-stage renal disease. Complications after kidney transplantation are common, which seriously affect the survival of the transplanted kidney. About 30% of the transplanted kidneys will suffer early loss of transplanted kidney function. Therefore, it is necessary to recognize and intervene the abnormal state of the transplanted kidney as soon as possible after kidney transplantation. [0003] Needle biopsy is currently the gold standard for evaluating the state of renal transplantation, but it is an invasive test with complications such as bleeding and large sampling errors, and its clinical application is limited. [0004] MRI cannot provide information such as the blo...

AI Technical Summary

Problems solved by technology

[0004] MRI cannot provide information such as the blood oxygen content of the transplanted kidney, and it is difficult to perform bedside real-time detection, which is expensive and takes a long time to scan

[0005] Ordinary CT can provide structural information of the transplanted kidney, but it is difficult to provide information about the function of the transplanted kidney; enhanced CT can reflect the blood perfusion of the transplanted kidney, but the contrast agent used has certain nephrotoxicity, and is easy to diffuse into the interstitium, iodine allergy It should be contraindicated or used with caution in patients. In addition, CT examination is also radioactive, so it is difficult to apply for long-term follow-up of transplanted kidneys

[0006] Ultrasound (B-ultrasound and Doppler) is non-invasive, convenient, and economical, and can display the structure and hemodynamic information of the transplanted kidney, but the inspection process is easily affected by the operator's technique and experience; although contrast-enhanced ultrasound can display the kidney in real time Blood perfusion, but ultrasound contrast agent is needed, it is difficult to provide more functional information, and the price of contrast agent is relatively expensive

[0007] Photoacoustic imaging has high resolution and can not only display microvessels, but also provide functional information such as blood oxygen content in renal blood vessels, oxygenated / deoxygenated hemoglobin content, etc., which solves the problems of ionizing radiation, poor resolution, Problems such as high cost, time-consuming and labor-intensive inspection, and less diagnostic information

However, photoacoustic imaging is poor in tissue structure and lacks sufficient positioning accuracy.

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