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Methods and systems for diagnosis and treatment of neural diseases and disorders

a neural disease and disorder technology, applied in the field of neural disease and disorder diagnosis and treatment, can solve the problems of patients being subjected to periods of over-treatment and under-treatment, limited effect, and difficult and often impossible to arrive at optimal treatment, so as to reduce time and the number of interactions

Inactive Publication Date: 2014-10-09
GLASS IAIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a system that can automatically determine the best way to treat a patient with deep brain stimulation. It does this by measuring the patient's brain activity and adjusting the treatment parameters until the disease state is minimized. This saves time and reduces the need for frequent physician visits, resulting in improved treatment outcomes. The system can optimize electrode polarities, waveform parameters, stimulation duty cycles, and other factors to achieve the best treatment for each patient.

Problems solved by technology

While such treatment modalities offer some benefits to patients, their efficacy is limited.
With such treatment modalities it is difficult and often impossible to arrive at an optimal treatment “magnitude,” that is, an optimal dose or intensity of treatment.
Furthermore, patients are subjected to periods of over-treatment and under-treatment due to variations in disease state.
Moreover, a particularly significant drawback to the above and other traditional treatment modalities is that they suffer from inconsistencies in treatment magnitude.

Method used

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  • Methods and systems for diagnosis and treatment of neural diseases and disorders
  • Methods and systems for diagnosis and treatment of neural diseases and disorders
  • Methods and systems for diagnosis and treatment of neural diseases and disorders

Examples

Experimental program
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Effect test

example 1

Pattern Recognition of Seizure

[0063]A group of subjects clinically diagnosed with epilepsy are individually evaluated using an EEG system for monitoring brain activity in the frontal cortical region. A control group of healthy subjects are individually evaluated in parallel using an EEG system. The EEG input is collected and analyzed, and a common pattern or patterns of epileptiform discharges is observed for the group of epileptic subjects.

example 2

Treatment of Seizure

[0064]A subject is evaluated using an embodiment of the invention in which EEG is detected as signal input and TMS is administered as either single pulsed or repetitive neuromodulatory stimulation output. The subject's brain activity is monitored using EEG, and the EEG input is analyzed. When the subject experiences seizure, a pattern of brain activity associated with seizure is identified, and TMS is administered to the subject by an operator or software following a seizure treatment protocol. The TMS is administered over a wide range of frequencies (0.5 Hz to over 100 Hz), periods encompassing single sessions to months of daily sessions, pulse widths and polarities. Over the course of treatment, the patient's seizure symptoms diminish, as evaluated by clinical factors as well as EEG analysis of brain activity.

example 3

Optimization of Neurostimulatory Location

[0065]A group of subjects clinically diagnosed with epilepsy are individually evaluated using an EEG system for monitoring brain activity. A second group of subjects clinically diagnosed with epilepsy are individually evaluated in parallel using an EEG system. The EEG input is collected and analyzed, and a common pattern or patterns of epileptiform discharges is observed for both groups of epileptic subjects when the subjects suffer epileptic seizures. The first group is treated with TMS according to a seizure treatment protocol, and the TMS is administered over a wide range of frequencies, periods, pulse widths, and polarities to a first cortical location on each subject within the group. The second group is treated with TMS according to a seizure treatment protocol, and the TMS is administered over a wide range of frequencies, periods, pulse widths, and polarities to a second cortical location on each subject within the group. Over the cour...

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PUM

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Abstract

The invention disclosed herein relates to methods and systems for modulating activity of a nervous system component. Neural pattern recognition is used to identify a neurological and / or psychiatric disease or disorder based on input generated by electric signals indicative of the subject's brain activity. In an embodiment, the method comprises receiving an input from one or more sensors, each sensor configured to sense a particular characteristic indicative of a neurological or psychiatric condition or state; developing treatment parameters based on the input received from the one or more sensors; and generating neural modulation signals for delivery to a nervous system component through one or more output devices in accordance with one or more developed treatment parameters.

Description

FIELD OF THE INVENTION[0001]The invention disclosed herein generally relates to methods and systems for neural pattern recognition in a subject suffering from a neurological and / or psychiatric disease or disorder based on input generated by electric signals indicative of the subject's brain activity.BACKGROUND OF THE INVENTION[0002]A number of techniques have been developed for controlling neurological conditions by electronically stimulating a pre-determined neurological region non-invasively. An example of such a technique is trancranial magnetic stimulation (TMS), which uses the principle of inductance to deliver electrical energy across the scalp and skull without the pain of direct percutaneous electrical stimulation.[0003]In general, these procedures involve identifying a discrete region of the brain and focusing fluctuating magnetic fields generated by one or more coils positioned proximate the head at a location that induces electric current in the identified region of the b...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N2/00
CPCA61N2/008A61N2/006A61B5/0059A61B5/055A61B5/4064A61B5/4076A61B5/4082A61B5/4094A61B8/488A61N1/0456A61N1/36025A61N1/36031A61B5/0036A61B5/30A61B5/375G16H50/50G16Z99/00
Inventor GLASS, IAIN
Owner GLASS IAIN
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