Mineralized collagen artificial periosteum and preparation method thereof

A technology for mineralizing collagen and artificial bone, applied in medical science, prosthesis, etc., can solve the problems of unfavorable bone defect healing, high immunogenicity, and fast degradation rate, and achieves beneficial repair, high bionic, broad The effect of the application foreground

Active Publication Date: 2014-10-15
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The immunogenicity of this material is high, and it is easy to cause immune rejection when implanted in the body, which is not conducive to the repair of bone defects.
Degradable polymer films include degradable natural biomass materials (such as chitosan), degradable synthetic materials (such as polylactic acid), etc. Natural biomass materials, as exogenous biological products, generally have the risk of triggering immune rejection , while the degradation products of artificial synthetic materials such as polylactic acid and poly

Method used

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  • Mineralized collagen artificial periosteum and preparation method thereof
  • Mineralized collagen artificial periosteum and preparation method thereof
  • Mineralized collagen artificial periosteum and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1, Preparation of 30 mm × 25 mm × 0.25 mm artificial periosteum

[0044] figure 1 Shown is the flow chart of the preparation method of the mineralized collagen artificial periosteum of the present invention. according to figure 1 As shown in the steps, the preparation steps of mineralized collagen artificial periosteum with a length of 30 mm, a width of 25 mm, and a thickness of 0.25 mm are as follows:

[0045] Step S1-1, dissolving 1 g of collagen in 2 L of 0.5 mol / L acetic acid solution to prepare a collagen acid solution;

[0046] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 30 mL of CaCl with a concentration of 0.2 mol / L dropwise 2 solution;

[0047] Step S1-3, continue to stir the solution obtained in step S1-2, and slowly add 30 mL of Na with a concentration of 0.12 mol / L dropwise 2 HPO 4 solution;

[0048] Step S1-4, continuously stirring the solution obtained in step S1-3, slowly adding 0.5 mol / L NaOH solution dropwise...

Embodiment 2

[0062] Example 2, Preparation of 50 mm × 20 mm × 0.4 mm artificial periosteum

[0063] according to figure 1 The steps shown, the preparation steps of mineralized collagen artificial periosteum with a length of 50 mm, a width of 20 mm, and a thickness of 0.4 mm are as follows:

[0064] Step S1-1, dissolving 1 g of collagen in 1 L of acetic acid solution with a concentration of 1 mol / L to prepare an acid solution of collagen;

[0065] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 100 mL of CaCl with a concentration of 0.05 mol / L dropwise 2 solution;

[0066] Step S1-3, continue to stir the solution obtained in step S1-2, slowly add 100 mL of Na with a concentration of 0.03 mol / L dropwise 2 HPO 4 solution;

[0067] Step S1-4, continuously stirring the solution obtained in step S1-3, slowly adding 0.5 mol / L NaOH solution dropwise until the pH of the mixed system = 7;

[0068] Step S1-5, let the mixed system obtained in step S1-4 stand for 60 hour...

Embodiment 3

[0078] Example 3, Preparation of 30 mm × 20 mm × 0.2 mm artificial periosteum

[0079] according to figure 1 The steps shown, the preparation steps of mineralized collagen artificial periosteum with a length of 30 mm, a width of 20 mm, and a thickness of 0.2 mm are as follows:

[0080] Step S1-1, dissolving 2 g of collagen in 5 L of acetic acid solution with a concentration of 0.25 mol / L to prepare a collagen acid solution;

[0081] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 50 mL of CaCl with a concentration of 0.15 mol / L dropwise 2 solution;

[0082] Step S1-3, continue to stir the solution obtained in step S1-2, and slowly add 50 mL of Na with a concentration of 0.1 mol / L dropwise 2 HPO 4 solution;

[0083] Step S1-4, continuously stirring the solution obtained in step S1-3, slowly adding 0.5 mol / L NaOH solution dropwise until the pH of the mixed system = 7;

[0084] Step S1-5. Let the mixed system obtained in step S1-4 stand for 72 hour...

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Abstract

The invention provides a mineralized collagen artificial periosteum. The artificial periosteum is prepared from mineralized collagen in which nano calcium phosphonium salt and collagen fibers are arranged in order, has substances and micro and macro structures, which are the same as a natural periosteum, also has a favorable mechanical property and biodegradation properties, and can be used for replacing and restoring the periosteum. The artificial periosteum can limit other bone grafting materials in the bone fracture parts in the restoring process to prevent the bone grafting materials from coming out and muscles, fat and other tissues from being extruded into the bone fracture parts, so that the restoring effect cannot be influenced. The pore structure of the artificial periosteum facilitates revascularization and conveying of nutrient substances, thereby benefiting restoring of bone fractures. Since the mineralized collagen artificial periosteum consists of nano calcium phosphonium salt and the collagen fibers, the artificial periosteum can be gradually degraded along with regeneration of bone tissues and the periosteums in the body. The invention also provides a preparation method of the artificial periosteum.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a mineralized collagen artificial periosteum used for periosteum replacement and repair and a preparation method thereof. Background technique [0002] Fractures, nonunions, and delayed bone unions are common orthopedic diseases in clinical practice. In addition to bone tissue defects, these diseases also involve periosteal defects. Therefore, while performing bone defect repair, the periosteal defect should also be repaired in order to achieve a better clinical repair effect. However, there are currently no artificial periosteum products available for clinical use. [0003] The periosteum is a thin film covering the surface of the bone except the joint part, which is a layer of strong connective tissue envelope. The natural periosteum can be divided into inner and outer layers: the outer layer is the fibrous layer, which is tightly combined with collagen fibers and contains...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/24A61L27/12A61L27/56
Inventor 陶春生仇志烨宋天喜张自强崔福斋
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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