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A kind of mineralized collagen artificial periosteum and preparation method thereof

A technology for mineralizing collagen and artificial bone, applied in medical science, prosthesis, etc., can solve the problems of high immunogenicity, unfavorable bone defect healing, and fast degradation rate, etc., to achieve high biomimetic, beneficial to repair, broad The effect of the application foreground

Active Publication Date: 2016-11-23
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The immunogenicity of this material is high, and it is easy to cause immune rejection when implanted in the body, which is not conducive to the repair of bone defects.
Degradable polymer films include degradable natural biomass materials (such as chitosan), degradable synthetic materials (such as polylactic acid), etc. Natural biomass materials, as exogenous biological products, generally have the risk of triggering immune rejection , while the degradation products of artificial synthetic materials such as polylactic acid and polyglycolic acid are acidic, which can easily cause aseptic inflammation, which is not good for bone mineralization
The existing collagen film products have defects such as poor mechanical properties and too fast degradation rate, which cannot meet the clinical performance requirements for artificial periosteum
Therefore, the existing membranous implant materials have relatively large defects, which are not conducive to the healing of bone defects, and are not suitable for use as a substitute for periosteum or for repairing periosteum.

Method used

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  • A kind of mineralized collagen artificial periosteum and preparation method thereof
  • A kind of mineralized collagen artificial periosteum and preparation method thereof
  • A kind of mineralized collagen artificial periosteum and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 ， 30 mm × 25 mm × 0.25 mm Preparation of artificial periosteum

[0043] figure 1 Shown is the flow chart of the preparation method of the mineralized collagen artificial periosteum of the present invention. according to figure 1 As shown in the steps, the preparation steps of mineralized collagen artificial periosteum with a length of 30 mm, a width of 25 mm, and a thickness of 0.25 mm are as follows:

[0044] Step S1-1, dissolving 1 g of collagen in 2 L of 0.5 mol / L acetic acid solution to prepare a collagen acid solution;

[0045] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 30 mL of CaCl with a concentration of 0.2 mol / L dropwise 2 solution;

[0046] Step S1-3, continue to stir the solution obtained in step S1-2, and slowly add 30 mL of Na with a concentration of 0.12 mol / L dropwise 2 HPO 4 solution;

[0047] Step S1-4, continuously stirring the solution obtained in step S1-3, slowly adding 0.5 mol / L NaOH solu...

Embodiment 2

[0061] Example 2 ， 50 mm × 20 mm × 0.4 mm Preparation of artificial periosteum

[0062] according to figure 1 The steps shown, the preparation steps of mineralized collagen artificial periosteum with a length of 50 mm, a width of 20 mm, and a thickness of 0.4 mm are as follows:

[0063] Step S1-1, dissolving 1 g of collagen in 1 L of acetic acid solution with a concentration of 1 mol / L to prepare an acid solution of collagen;

[0064] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 100 mL of CaCl with a concentration of 0.05 mol / L dropwise 2 solution;

[0065] Step S1-3, continue to stir the solution obtained in step S1-2, slowly add 100 mL of Na with a concentration of 0.03 mol / L dropwise 2 HPO 4 solution;

[0066] Step S1-4, continuously stirring the solution obtained in step S1-3, slowly adding 0.5 mol / L NaOH solution dropwise until the pH of the mixed system = 7;

[0067] Step S1-5, let the mixed system obtained in step S1-4 stan...

Embodiment 3

[0077] Example 3 ， 30 mm × 20 mm × 0.2 mm Preparation of artificial periosteum

[0078] according to figure 1 The steps shown, the preparation steps of mineralized collagen artificial periosteum with a length of 30 mm, a width of 20 mm, and a thickness of 0.2 mm are as follows:

[0079] Step S1-1, dissolving 2 g of collagen in 5 L of acetic acid solution with a concentration of 0.25 mol / L to prepare a collagen acid solution;

[0080] Step S1-2, keep stirring the solution obtained in Step S1-1, slowly add 50 mL of CaCl with a concentration of 0.15 mol / L dropwise 2 solution;

[0081] Step S1-3, continue to stir the solution obtained in step S1-2, and slowly add 50 mL of Na with a concentration of 0.1 mol / L dropwise 2 HPO 4 solution;

[0082] Step S1-4, continuously stirring the solution obtained in step S1-3, slowly adding 0.5 mol / L NaOH solution dropwise until the pH of the mixed system = 7;

[0083] Step S1-5. Let the mixed system obtained in step S1-4 stan...

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Abstract

The invention provides a mineralized collagen artificial periosteum. The artificial periosteum is made of mineralized collagen in which nano calcium phosphate and collagen fibers are arranged in an orderly manner. It has the same material composition and microscopic and macroscopic structure as the natural periosteum, and has good Mechanical properties and biodegradable properties can be used for periosteum replacement and repair. The artificial periosteum of the present invention can limit other bone grafting materials to the bone defect during the repair process, avoiding bone graft material prolapse and muscle, fat and other tissues being squeezed into the bone defect, affecting the repair effect. The pore structure of the artificial periosteum is beneficial to the regeneration of blood vessels and the delivery of nutrients, thereby benefiting the repair of bone defects. Since the mineralized collagen artificial periosteum is composed of nano-calcium phosphate and collagen fibers, the artificial periosteum can be gradually degraded in vivo with the regeneration of bone tissue and periosteum. The invention also provides a preparation method of the artificial periosteum.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a mineralized collagen artificial periosteum used for periosteum replacement and repair and a preparation method thereof. Background technique [0002] Fractures, nonunions, and delayed bone unions are common orthopedic diseases in clinical practice. In addition to bone tissue defects, these diseases also involve periosteal defects. Therefore, while performing bone defect repair, the periosteal defect should also be repaired in order to achieve a better clinical repair effect. However, there are currently no artificial periosteum products available for clinical use. [0003] The periosteum is a thin film covering the surface of the bone except the joint part, which is a layer of strong connective tissue envelope. The natural periosteum can be divided into inner and outer layers: the outer layer is the fibrous layer, which is tightly combined with collagen fibers and contains...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/24A61L27/12A61L27/56
Inventor 陶春生仇志烨宋天喜张自强崔福斋
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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