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Injectable calcium phosphate cements and the preparation and use thereof

a calcium phosphate cement and injection technology, applied in the field of calcium phosphate cement, can solve the problems of inability to achieve the desired effect,

Inactive Publication Date: 2005-12-08
CALCITEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] In order to accomplish the above objects of the present invention a calcium phosphate cement prepared in accordance with the present invention comprises calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm. By adjusting the diameter of the calcium phosphate particles, the width and / or the length of the whiskers or fine crystals, the inventors of the present invention are able to adjust the working time and / or the setting time of the calcium phosphate cement of the present invention to conform to requirements for various purposes. Moreover, the calcium phosphate cement of the present invention is fast-setting, and is non-dispersive in water or an aqueous solution.

Problems solved by technology

In general, the prior art calcium phosphate cements suffer one or more drawbacks as follows: 1) additives having a relatively poor bioactivity being required; 2) a complicated preparation process; 3) an undesired setting time or working time of CPC, which are difficult to be adjusted; 4) not capable of being set to a desired shape in water, blood or body fluid; and 5) poor initial strength after setting of the CPC.

Method used

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  • Injectable calcium phosphate cements and the preparation and use thereof
  • Injectable calcium phosphate cements and the preparation and use thereof
  • Injectable calcium phosphate cements and the preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Heating Treatment

[0036] 5 g of Ca(H2PO4)2.H2O powder and 1.6 ml of 25 mM phosphoric acid aqueous solution were mixed, and stirred for one minute. The resulting mixture was placed into an oven at 50° C. for 15 minutes, and the resulting dried mixture was mechanically ground for 20 minutes to fine particles after being removed from the oven. 1 g of the fine particles and 0.4 ml of phosphate aqueous solution (1.0 M, pH=6.0) were mixed to form a paste, which was tested every 30 seconds to determine the working time and the setting time. The setting time is the time required when a 1 mm diameter pin with a load of ¼ pounds can be inserted only 1 mm deep into the surface of the paste. The working time is the time after which the paste is too viscous to be stirred. The working time of the paste of this example is 30 minutes and the setting time thereof is one hour.

[0037] The paste was placed in a relatively large amount of deionized water immediately following the formation thereof, and ...

example 2

Vacuuming Treatment

[0038] 5 g of CaHPO4 (DCPA) powder and 1.2 ml of 25 mM phosphoric acid aqueous solution were mixed, and stirred for one minute. The resulting mixture was placed in a vacuum environment of −100 Pa for 30 minutes, and the resulting dried mixture was mechanically ground for 20 minutes to fine particles. 1 g of the fine particles and 0.4 ml of phosphate aqueous solution (1.0 M, pH=6.0) were mixed to form a paste, which was tested every 30 seconds to determine the working time and the setting time. The working time of the paste of this example is 20.5 minutes and the setting time thereof is 24 minutes.

[0039] The paste was placed in a relatively large amount of deionized water immediately following the formation thereof, and it was observed that the paste was non-dispersive in deionized water.

example 3

Organic Solvent Treatment

[0040] 5 g of CaHPO4 (DCPA) powder and 1.6 ml of 25 mM phosphoric acid aqueous solution were mixed, and stirred for one minute. To the resulting mixture 1.6 ml of acetone was added while stirring to form a paste followed by placing in a vacuum environment of −100 Pa for one hour, and the resulting dried mixture was mechanically ground for 20 minutes to fine particles. 1 g of the fine particles and 0.4 ml of phosphate aqueous solution (1.0 M, pH=6.0) were mixed to form a paste, which was tested every 30 seconds to determine the working time and the setting time. The working time of the paste of this example is 20.0 minutes and the setting time thereof is 22.0 minutes.

[0041] The paste was placed in a relatively large amount of deionized water immediately following the formation thereof, and it was observed that the paste was non-dispersive in deionized water.

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Abstract

A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.

Description

RELATED APPLICATION [0001] This application is a continuation-in-part and claims the benefit of priority under 35 USC §120 of U.S. application Ser. No. 09 / 615,384, filed Jul. 13, 2000. The disclosure of the prior application is considered part of and is incorporated by reference in the disclosure of this application.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention is related to a calcium phosphate cement, and in particular a fast-setting calcium phosphate cement, for use in dental and bone prosthesis. [0004] 2. Description of the Related Art [0005] A calcium phosphate cement (abbreviated as CPC) has been widely used as an implant or filling material in dental and bone prosthesis, and its technical details can be found in many patents, for examples U.S. Pat. Nos. 4,959,104; 5,092,888; 5,180,426; 5,262,166; 5,336,264; 5,525,148; 5,053,212; 5,149,368; 5,342,441; 5,503,164; 5,542,973; 5,545,254; 5,695,729 and 5,814,681. In general, the prior art ...

Claims

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Application Information

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IPC IPC(8): A61C5/00A61C5/06A61K6/838A61K33/42A61L24/00A61L24/02A61L27/12A61L27/50C04B12/02C04B14/36C04B28/34
CPCA61K6/033A61K33/42A61L24/001A61L24/02A61L27/12A61L27/50C04B12/02C04B12/025C04B14/366C04B28/34C04B28/344C04B28/346C04B2111/00836C04B20/008C04B40/0272C04B40/0218C04B40/0263C04B20/1014C04B22/064C04B22/126C04B20/023C04B20/107A61K6/0008A61K6/0067A61K6/0643A61K6/087C08L89/00Y10T428/2991Y10T428/2993A61C5/62A61K6/69A61K6/17A61K6/838A61K6/864A61P19/00A61K6/891
Inventor CHERN LIN, JIIN-HUEYJU, CHIEN-PINGCHEN, WEN-CHENG
Owner CALCITEC
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