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3D-printed multi-structure bone composite scaffold

A composite scaffold and 3D printing technology, which is applied in 3D printing, bone implants, prostheses, etc., can solve the problems of not rationally utilizing the composite performance of PCL and TCP, and not fully simulating osteogenesis, so as to promote adhesion and improve bone formation. Adhesion, performance-improving effect

Active Publication Date: 2020-05-08
NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent prepares a double-layer artificial bone, but the double-layer is used for hard bone growth and cartilage growth respectively, and does not fully simulate the structure of osteogenesis and bone repair, nor does it make reasonable use of the composite performance of PCL and TCP

Method used

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  • 3D-printed multi-structure bone composite scaffold
  • 3D-printed multi-structure bone composite scaffold
  • 3D-printed multi-structure bone composite scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] ①3D printing steps:

[0045] The printer used for 3D printing is OPUS, and the specific parameters are selected according to the ingredients of the mixture. The optional parameters include printing pressure, printing speed, printing temperature, fiber diameter, fiber spacing, and porosity; the specific steps of 3D printing are as follows: design the bracket Print the model, mix PCL and TCP in proportion to make a composite material, then put the composite material into the 3D printer, set the corresponding parameters, extrude through the fine nozzle, and the fiber layers are superimposed to form a scaffold.

[0046] ②Adopt the above 3D printing steps, adjust the ratio of printing raw materials and print models, and print out various 3D printing composite scaffolds. The molecular weight of PCL is 43000; the purity of TCP is greater than or equal to 96%:

[0047] a. The final printing parameters are obtained by optimizing the outer layer components of the bionic bone stru...

Embodiment 2

[0061] The same steps and parameters as in Example 1 are used, but the difference from Example 1 is that after printing, the surface of the scaffold is modified, and the most suitable surface modification method is selected according to the optimization. The method of NaOH immersion, the specific steps The procedure is as follows: soak the printed scaffold in a 3M NaOH solution for 24 hours at 37° C. and then take it out.

[0062] Figure 9 Scanning electron micrograph of the scaffold microstructure after surface modification with NaOH: the surface is modified to form a small pore structure, and the surface roughness is further enhanced, which is conducive to the adhesion and growth of cells.

Embodiment 3

[0064] ①3D printing steps:

[0065]The printer used for 3D printing is OPUS, and the specific parameters are selected according to the ingredients of the mixture. The optional parameters include printing pressure, printing speed, printing temperature, fiber diameter, fiber spacing, and porosity; the specific steps of 3D printing are as follows: design the bracket Print the model, dissolve polylactic acid (PLA) in chloroform to prepare a solution with a mass concentration of 20%, and then add hydroxyapatite (HA) in proportion to make a composite material, and then put the composite material into a 3D printer. The corresponding parameters are set, extruded through a fine nozzle, the fiber layers are stacked to form a scaffold, and then the chloroform is removed by volatilization.

[0066] ②Adopt the above 3D printing steps, adjust the ratio of printing raw materials and print models, and print out various 3D printing composite scaffolds. The average molecular weight of PLA is 12...

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Abstract

The invention relates to a 3D-printed multi-structure bone composite scaffold. The 3D-printed multi-structure bone composite scaffold comprises a multi-layer structure, wherein different layers are made of composite materials in different proportions through 3D printing, and the 3D-printed multi-structure bone composite scaffold has different 3D printing fiber spacings and porosity factors. The specific structure comprises a bionic bone structure, the outer layer is low in porosity and small in aperture to simulate a compact bone structure, the inner layer is high in porosity and large in aperture to simulate a cancellous bone structure, and the scaffold similar to a real bone structure is integrally formed; in an osseointegration structure, the outer layer is high in porosity and large inaperture so as to promote integration with surrounding bones, the inner layer is low in porosity and small in aperture so as to support the overall structure while promoting osseointegration, and thewhole structure is suitable for repairing bone defects. The material of the scaffold is preferably a composite material of tricalcium phosphate (TCP) and polycaprolactone (PCL), and the scaffold hasgood biocompatibility and printability. The bone repair effect is promoted by adding metal ions and performing surface modification treatment.

Description

technical field [0001] The invention relates to the field of bone composite scaffolds, in particular to a 3D printed multi-structure composite bone scaffold. Background technique [0002] As the largest tissue and organ in the human body, bone plays a very important role in providing mechanical support for joints, tendons and ligaments, protecting vital organs, hematopoiesis and maintaining normal calcium and phosphorus metabolism balance in the body. There are countless patients with bone defects caused by accidental injury, aging, inflammation, tumor and congenital malformation. The treatment of bone defects is inseparable from the reconstruction of bone tissue, and when reconstructing the tissue structure of bone defects, suitable filling materials are needed to replace the original missing bone. There are more or less defects in autologous bone, allograft bone or other filling materials used in clinical practice. With the emergence of bone tissue engineering and 3D pri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/28A61F2002/30028A61F2002/30062A61F2002/30622A61F2002/30985A61F2210/0004A61F2210/0076A61F2250/0014A61F2250/0023A61F2310/00005
Inventor 杨熙柯东旭崔文国余嘉
Owner NOVAPRINT THERAPEUTICS SUZHOU CO LTD
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