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Preparation method of calcium orthophosphate bone cement degradable to pore in human body

A technology of calcium phosphate bone cement and calcium dihydrogen phosphate, which is applied in the field of medical bone cement material preparation, and can solve problems such as limiting the application range of materials, reducing material strength, and increasing pore size and porosity

Inactive Publication Date: 2006-02-22
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above studies, although the porosity of the bone cement material increased, the in vivo degradation rate and osteogenesis ability of the material were improved, but the problem of the decrease of the material strength caused by the increase of the pore size and porosity could not be solved.
Its compressive strength is only about one-tenth of that of ordinary microporous calcium phosphate bone cement, and it can only be used for the repair of bone defects with no bearing capacity or very low bearing capacity, which severely limits the application range of this material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Mix α-type tricalcium phosphate, calcium dihydrogen phosphate and calcium carbonate powder in molar ratio:

[0023] α-type tricalcium phosphate: calcium dihydrogen phosphate: calcium carbonate = 8: 1: 3, ball milling and mixing in absolute ethanol medium, and drying at 80°C to prepare calcium phosphate bone cement solid phase powder;

[0024] (2) Add 8 grams of sodium chloride, 0.35 grams of sodium bicarbonate, 0.23 grams of potassium chloride, 0.23 grams of dipotassium hydrogen phosphate, 0.31 grams of magnesium chloride, 0.28 grams of calcium chloride, and sodium sulfate in 1000 milliliters of deionized water or distilled water. 0.07 grams, 6.06 grams of Tris, prepare simulated body fluid, and adjust the pH value of the simulated body fluid to 7.2 with hydrochloric acid solution of 0.5 molar concentration;

[0025] (3) After the chitosan microspheres are cleaned and dried with deionized water, they are placed in a glass container, and the simulated body fluid prep...

Embodiment 2

[0033] (1) Mix α-type tricalcium phosphate, calcium dihydrogen phosphate and calcium carbonate powder in molar ratio:

[0034] α-type tricalcium phosphate: calcium dihydrogen phosphate: calcium carbonate=12:2:5 were ball-milled and mixed in absolute ethanol medium, and dried at 100°C to prepare calcium phosphate bone cement bone phase powder;

[0035] (2) Add 24 grams of sodium chloride, 1.01 grams of sodium bicarbonate, 0.69 grams of potassium chloride, 0.69 grams of dipotassium hydrogen phosphate, 0.93 grams of magnesium chloride, 0.84 grams of calcium chloride, and sodium sulfate in 1000 milliliters of deionized water or distilled water. 0.21 grams, 18.18 grams of Tris, prepare simulated body fluid, and adjust the pH value of the simulated body fluid to 7.4 with 1 molar hydrochloric acid solution;

[0036] (3) After the chitosan microspheres are cleaned and dried with deionized water, they are placed in a glass container, and the simulated body fluid prepared in step (2) is...

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Abstract

The invention relates to a preparation method for calcium phosphate aggregate cement that can degradate in human body, which comprises: preparing said cement powder by alpha-type tricalcium phosphate, calcium biphosphate and calcium carbonate powder; adding chitose microsphere in prepared analog body fluid, clearing and drying to mix with said solid powder to prepare composite powder; using buffle solution to add baking soda and sodium alginate to prepare solidification liquid; finally, mixing the powder and liquid to prepare composite slurry.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical bone cement materials, in particular to a method for preparing calcium phosphate porous bone cement composite materials. Background technique [0002] Cured calcium phosphate bone cement has the characteristics of in-situ curing at room temperature or human physiological environment temperature, the structure and composition of the cured body are similar to the structure and composition of natural bone mineral phase, it can be shaped arbitrarily during surgery, and can fill bone defects of various shapes, etc. , can be widely used in clinical fields such as fracture fixation, bone defect repair, dental and maxillofacial surgery repair, and drug carrier, and is a research hotspot in the field of bone repair and hard tissue replacement materials. [0003] Although the ordinary calcium phosphate bone cement material also has a certain porosity, but because the pore size is nanometer or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B12/02C04B22/16C04B22/14C04B2/12C04B24/14
Inventor 董利民王晨昝青峰刘锐李兆新田杰谟
Owner TSINGHUA UNIV
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