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Adsorbable internal fixing material for bone fracture and its preparing process

A fixation material and fracture technology, applied in the field of fracture internal fixation material and its preparation, can solve the problems of unfavorable inflammatory reaction of internal fixator, poor bioabsorption performance, influence on the function of healing bone, etc. Improved biodegradability and easy absorption

Inactive Publication Date: 2002-11-27
SOUTHEAST UNIV
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AI Technical Summary

Problems solved by technology

However, the bioabsorption of hydroxyapatite (HAP) is not very good, which may affect the function of the healing bone, and because the biodegradation of HAP is slow, it is unfavorable to eliminate the inflammatory reaction of the internal fixator

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The invention uses polylactic acid, tricalcium phosphate and hydroxyapatite as raw materials.

[0018] The above-mentioned polylactic acid is ring-opening polymerization to obtain polylactic acid, including poly-L-lactic acid, poly(D, L)-lactic acid, or a blend of the two or L-lactic acid-(D, L)-lactic acid copolymer, polymer The molecular weight is 150,000 to 1,500,000.

[0019] The above-mentioned tricalcium phosphate and hydroxyapatite are all synthesized by wet method. The raw materials are dried and pulverized by ball milling to obtain powdery materials with a particle size of 50 nanometers to 100 micrometers. The powder tricalcium phosphate and hydroxyapatite with a particle size of about 100 nanometers can be easily obtained by ball milling.

[0020] The invention obtains the composite material through mechanical mixing or precipitation mixing of polylactic acid, tricalcium phosphate and hydroxyapatite.

[0021] Add the composite material prepared above into t...

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Abstract

An absorbable internal fixing material for bone fracture is prepared from polylactic acid (50-90 wt.%), tricalcium phosphate (1-40 wt.%) and hydroxylapatitie (1-40 wt.%) through mixing then and then hot die pressing at 80-1230 deg.C and under 0.11-25 MPa or hot extruding at 80-230 deg.c. The granulality of hydroxylapatite and tricalcium phosphate is less than 100 microns. Its advantages are high strength, high strength, high X-ray visualization and high biocompatibility.

Description

1. Technical field: [0001] The invention relates to an absorbable fracture internal fixation material and a preparation method thereof, belonging to the technical field of preparation of materials for medical surgery. 2. Background technology: [0002] Bone internal fixator is an indispensable medical device for orthopedic treatment of fractures and bone trauma. Currently commonly used fracture internal fixators are metal materials or absorbable polymer materials. The internal fixator made of stainless steel or titanium alloy has high strength, low cost and high frequency of use. The main problem of this type of bone nail is that after the fracture heals, a second operation is required to remove it; secondly, due to the stress shielding effect, it is likely to cause bone resorption, bone atrophy, prone to secondary fractures, and delay the initial bone healing; Poor capacity can lead to inflammatory reactions and so on. [0003] The bone internal fixator made of bioabsorb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/58A61L31/06B29C43/02
Inventor 李新松浦跃朴齐新生哈涌泉
Owner SOUTHEAST UNIV
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