The invention relates to a traditional Chinese medicine composition for invigorating yang, consolidating basis, expelling pestilence and killing epidemic diseases and a preparation method thereof. According to the traditional Chinese medicine composition for invigorating yang, consolidating basis, expelling pestilence and killing epidemic diseases, sixteen traditional Chinese medicines such as folium artemisiae argyi, rhizoma atractylodis, artemisia apiacea, winged euonymus twigs, liquorice and the like are adopted as raw materials and are proportioned according to a proper weight ratio, and finally the traditional Chinese medicine composition capable of effectively expelling pestilence, killing epidemic diseases and preventing infectious diseases is prepared. According to the traditionalChinese medicine composition, all raw material components have a synergistic effect, the effects of sterilization, virus resistance, pestilence expelling and epidemic killing are achieved through spraying or fumigation, there is no dead angle which is left in the environment, and a purpose of thoroughly preventing infectious diseases is achieved; a pure traditional Chinese medicine preparation hasno toxic or side effect on human bodies, is suitable for hospitals, families, shopping malls, companies, schools, organs and units and other public places, and has no pollution to the environment; and the effects of invigorating yang, consolidating the basis, refreshing mind, restoring consciousness and dispelling fatigue are stronger. The preparation method of the traditional Chinese medicine composition is simple and feasible, and is suitable for large-scale popularization and application.